12 research outputs found
Probiotics in allergy treatment: a literature review
Allergy is a exacerbate response of immune system to a triggering element. A probable cause of allergies is gut microbiota composition. It has strong relationship with development of human immune system and this is formed in intrauterine life and early childhood, crucial periods for formation adequate microbiota. In this sense modulation gut microbiota by probiotics could prevent or help in the treatment of allergic diseases such as allergic rhinitis, asthma, atopic dermatitis and food allergy. Studies published to date are controversial. It is difficult to determine whether the probiotic can be used in the treatment and prevention of allergic diseases
Interrogation of the perturbed gut microbiota in gouty arthritis patients through in silico metabolic modeling
Recent studies have shown perturbed gut microbiota associated with gouty arthritis, a metabolic disease characterized by an imbalance between uric acid production and excretion. To mechanistically investigate altered microbiota metabolism associated with gout disease, 16S rRNA gene amplicon sequence data from stool samples of gout patients and healthy controls were computationally analyzed through bacterial community metabolic models. Patient-specific community models constructed with the metagenomics modeling pipeline, mgPipe, were used to perform k-means clustering of samples according to their metabolic capabilities. The clustering analysis generated statistically significant partitioning of samples into a Bacteroides-dominated, high gout cluster and a Faecalibacterium-elevated, low gout cluster. The high gout cluster was predicted to allow elevated synthesis of the amino acids D-alanine and L-alanine and byproducts of branched-chain amino acid catabolism, while the low gout cluster allowed higher production of butyrate, the sulfur-containing amino acids L-cysteine and L-methionine, and the L-cysteine catabolic product H2S. By expanding the capabilities of mgPipe to provide taxa-level resolution of metabolite exchange rates, acetate, D-lactate and succinate exchanged from Bacteroides to Faecalibacterium were predicted to enhance butyrate production in the low gout cluster. Model predictions suggested that sulfur-containing amino acid metabolism generally and H2S more specifically could be novel gout disease markers
ProbiĂłticos en el tratamiento de alergias: una revisiĂłn
La alergia es una respuesta exacerbada del sistema inmunitario a un elemento desencadenante. Una probable causa de las alergias es la composiciĂłn del microbioma intestinal. Tiene una fuerte relaciĂłn con el desarrollo del sistema inmunitario humano y se forma en la vida intrauterina y en la primera infancia, perĂodos cruciales para la formaciĂłn de la microbiota adecuada. En este sentido, la modulaciĂłn de la microbiota intestinal por los probiĂłticos podrĂa prevenir o ayudar en el tratamiento de enfermedades alĂ©rgicas como la rinitis alĂ©rgica, el asma, la dermatitis atĂłpica y la alergia alimentaria. Los estudios publicados hasta la fecha son controvertidos. Es difĂcil determinar si los probiĂłticos pueden usarse en el tratamiento y prevenciĂłn de enfermedades alĂ©rgicas.Allergy is a exacerbate response of immune system to a triggering element. A probable cause of allergies is gut microbiota composition. It has strong relationship with development of human immune system and this is formed in intrauterine life and early childhood, crucial periods for formation adequate microbiota. In this sense modulation gut microbiota by probiotics could prevent or help in the treatment of allergic diseases such as allergic rhinitis, asthma, atopic dermatitis and food allergy. Studies published to date are controversial. It is difficult to determine whether the probiotic can be used in the treatment and prevention of allergic diseas
The Effects of Limosilactobacillus reuteri LR-99 Supplementation on Body Mass Index, Social Communication, Fine Motor Function, and Gut Microbiome Composition in Individuals with PraderâWilli Syndrome: a Randomized Double-Blinded Placebo-Controlled Trial
Potential biomarkers of infertility associated with microbiome imbalances
PROBLEM: The aim of this study was to investigate the possible relationship between vaginal/rectal microbiome disbalances and miRNA expression with infertility. METHOD OF STUDY: Observational, exploratory, preliminary study. A total of 287 multiple IVF failure infertile patients were recruited. Twenty fertile women, not IVF failure, were recruited as the control group. Swab samples were collected from the vagina and rectum. Microbial composition by NGS and miRNA expression by real-time PCR of vaginal and rectal samples was measured. Immunometabolic markers from blood (insulin, vitamin D, LDL-cholesterol, ANA, TPO, Tg, and ASCA antibodies) and saliva (sIgA) were analyzed. RESULT(S): Infertile patients showed a lower bacterial richness and increased Firmicutes/Bacteroidetes ratio at rectal level and an increased Lactobacillus brevis/Lactobacillus iners ratio in vaginal samples regarding the fertile group. In the same rectal swab samples, we found that miR-21â5p, which is associated with tight junction disruption and yeast overgrowth, is upregulated and that miR-155â5p, which is associated with inflammation, is overexpressed in the unexplained infertile group (*p < .05). These deregulated miRNAs were also upregulated in the vaginal samples from the same patients (*p < .05). CONCLUSION: miRNAs could be potential biomarkers of the inflammatory impact of microbiome disbalances in unexplained infertile women