5,996 research outputs found
Spin-flop transition driven by competing magnetoelastic anisotropy terms in a spin-spiral antiferromagnet
Holmium, the archetypical system for spin-spiral antiferromagnetism, undergoes an in-plane spin-flop transition earlier attributed to competing symmetry-breaking and fully symmetric magnetoelastic anisotropy terms [Phys. Rev. Lett. 94, 227204 (2005)], which underlines the emergence of sixfold magnetoelastic constants in heavy rare earth metals, as otherwise later studies suggested. A model that encompasses magnetoelastic contributions to the in-plane sixfold magnetic anisotropy is laid out to elucidate the mechanism behind the spin-flop transition. The model, which is tested in a Ho-based superlattice, shows that the interplay between competing fully symmetric a-magnetoelastic and symmetry-breaking ¿-magnetoelastic anisotropy terms triggers the spin reorientation. This also unveils the dominant role played by the sixfold exchange magnetostriction constant, where D66a2¿0.32 GPa against its crystal-field counterpart M66a2¿-0.2 GPa, in contrast to the crystal-field origin of the symmetry-breaking magnetostriction in rare earth metals
Analysis of water-soluble vitamins in biopharma raw materials by electrophoresis micro-chips with contactless conductivity detection
Detailed information concerning the composition of the raw materials employed in the production
of biologics is important for the efficient control and optimization of bioprocesses. The analytical
methods used in these applications must be simple and fast as well as be easily transferable from
one site to another. In that context, microchip‐based electrophoresis represents a promising tool
for application in the analysis of raw materials in biologics. Using electrophoresis micro‐chips,
analysis times can be reduced to seconds and high separation efficiencies can be achieved using
extremely low volume samples, minimal reagent consumption and waste generation, low
cost/disposability, portability and ease of mass‐production [1].
Additionally the use of Capacitively Coupled Contactless Conductivity Detection (C4D) offers a
rather simple and yet sensitive method for detection of ionic species. Recently, C4D has gained
much popularity as on‐chip detection in electrophoresis micro‐chips [2]. The main reason for this
is that there is no physical contact of the detection electrodes with the electrolyte solution.
Therefore, the integration of this detection mode within the analytical system is rather simple.
Furthermore, the background noise is significantly reduced leading to lower detection limits than
the conventional contact conductivity detection.
Vitamins are present at very low concentrations in biopharma raw materials and are usually
determined using HPLC and CE methods [3]. Electrophoresis micro‐chips are a very good
alternative to these techniques due to the shorter analysis time and yet very good resolution,
among others.
In this paper, we present the application of electrophoresis micro‐chips with C4D detection to the
analysis of water‐soluble vitamins in raw materials used for the production of biologics in
bioreactors. For that purpose, hybrid PDMS/glass chips were fabricated by using standard
photolithographic techniques (Figure 1). The chip structure contains an extremely long channel of
101 mm (50 x 50 μm width x depth). Figure 2 shows the setup used for vitamins detection
Analysis of biopharma raw materials by electrophoresis microchips with contactless conductivity detection
Detailed information concerning the composition of the raw materials employed in the production of biologics is important for the efficient control and optimization of bioprocesses. We demonstrate the application of electrophoresis microchips with capacitively-coupled contactless conductivity detection (C4D) to the analysis of wa-ter-soluble vitamins and metal cations in raw material solutions that are subse-quently fed into bioreactors for the production of biologics
Universal scaling of the magnetic anisotropy in two-dimensional rare-earth layers
Unraveling the influence that low dimensionality has upon the spin's stability in two-dimensional (2D) systems is instrumental for the efficient engineering of energy barriers in ultrathin magnetic layers. Taking rare-earth-based ultrathin multilayered nanostructures as a model system, we have investigated the dissimilar impact that low dimensionality and finite-size effects have upon the magnetic anisotropy energy (MAE) at the nanoscale. We conclusively show that the reduced dimensionality of the spin's system in 2D ferromagnetic layers imprints on the MAE constants a universal temperature decay as a quadratic power law of the reduced magnetization. This result is in agreement with predictions, although in marked contrast to the rank-dependent, thereby faster, decay of the MAE constants observed in three-dimensional nanostructures
Real Time Synthesized Sound Effects Web Service
Sound effects are employed in the post-production process in order to create tension, atmosphere, and emotion, as well as add focus to desired aspects of a scene. Traditionally sound designers are required to either source these sounds from commercially available libraries or to record audio them- selves. Additionally, sound designers are usually required to manually manipulate these sources in order to accurately sonify the scene. This whole process requires time, planning and effort from the sound designer
Inhomogeneous Loop Quantum Cosmology: Hybrid Quantization of the Gowdy Model
The Gowdy cosmologies provide a suitable arena to further develop Loop
Quantum Cosmology, allowing the presence of inhomogeneities. For the particular
case of Gowdy spacetimes with the spatial topology of a three-torus and a
content of linearly polarized gravitational waves, we detail a hybrid quantum
theory in which we combine a loop quantization of the degrees of freedom that
parametrize the subfamily of homogeneous solutions, which represent Bianchi I
spacetimes, and a Fock quantization of the inhomogeneities. Two different
theories are constructed and compared, corresponding to two different schemes
for the quantization of the Bianchi I model within the {\sl improved dynamics}
formalism of Loop Quantum Cosmology. One of these schemes has been recently put
forward by Ashtekar and Wilson-Ewing. We address several issues including the
quantum resolution of the cosmological singularity, the structure of the
superselection sectors in the quantum system, or the construction of the
Hilbert space of physical states.Comment: 16 pages, version accepted for publication in Physical Review
Trypanosoma brucei gambiense in domestic livestock of Kogo and Mbini foci (Equatorial Guinea).
OBJECTIVE: To evaluate Trypanosoma brucei gambiense infection in peri-domestic livestock from Kogo and Mbini foci (Equatorial Guinea) in order to investigate its possible implication in the sleeping sickness transmission cycle in these hypoendemic foci. METHODS: Samples from 698 domestic animals (goats, sheep and pigs) from trypanosomiasis-endemic localities of Kogo and Mbini foci were tested for animal trypanosomes and T. b. gambiense (group I) by species-specific polymerase chain reaction. RESULTS: Trypanosoma brucei s.l., the predominant trypanosome species, was detected in 182 (52.6%) samples from Mbini and in 127 (36.1%) samples from Kogo. T. b. gambiense was only identified in seven (2%) of the Mbini samples and one co-infection (with T. vivax) was observed. CONCLUSION: The occurrence of T. b. gambiense in peri-domestic livestock in Mbini and its absence in Kogo could explain the epidemiological differences between the two foci and could have significant implications for sleeping sickness control in Equatorial Guinea
Investigations on the distribution of air transport traffic and CO2 emissions within the European Union
This study analyses the structure of air traffic and its distribution among the different countries in the European Union, as well as traffic with an origin or destination in non-EU countries. Data sources are Eurostat statistics and actual flight information from EUROCONTROL. Relevant variables such as the number of flights, passengers or cargo tonnes and production indicators (RPKs) are used together with fuel consumption and CO2 emissions data. The segmentation of air traffic in terms of distance permits an assessment of air transport competition with surface transport modes. The results show a clear concentration of traffic in the five larger countries (France, Germany, Italy, Spain and UK), in terms of RPKs. In terms of distance the segment between 500 and 1000 km in the EU, has more flights, passengers, RTKs and CO2 emissions than larger distances. On the environmental side, the distribution of CO2 emissions within the EU Member States is presented, together with fuel efficiency parameters. In general, a direct relationship between RPKs and CO2 emissions is observed for all countries and all distance bands. Consideration is given to the uptake of alternative fuels. Segmenting CO2 emissions per distance band and aircraft type reveals which flights contribute the most the overall EU CO2 emissions. Finally, projections for future CO2 emissions are estimated, according to three different air traffic growth and biofuel introduction scenarios
Comunicación corta. Rhizoctonia solani, agente causal de la muerte de plántulas de acelga en España
During September 2011, post-emergence damping off of Swiss chard (Beta vulgaris subsp. cicla L.) was observed in a greenhouse in Villa del Prado (Spain). About 20% of the seedlings showed damping off symptoms. Lesions were initially water soaked, dark brown necrosis of crown tissue, irregular in shape and sunken in appearance on large plants, causing the infected seedlings to collapse and eventually die. Rhizoctonia solani was isolated consistently from symptomatic plants. After morphological and molecular identification of the isolates, pathogenicity was tested by placing agar plugs of four isolates adjacent to the stem at the three or four true leaf stage. In inoculated plants, brown crown and stem necrosis occurred while control plants did not show disease symptoms. Pathogenicity using non-germinated seeds was also tested. All four isolates produced extensive damping off when inoculated on non-germinated seeds. To our knowledge, this is the first report of damping off of Swiss chard caused by R. solani in Europe.En el mes de septiembre de 2011, se observó muerte de plántulas en acelgas cultivadas en un invernadero en Villa del Prado (España). Cerca del 20% de los semilleros mostraban síntomas de caída de plántulas. Las lesiones iniciales tenían un aspecto húmedo y consistían en una necrosis del tejido de la corona de color marrón oscuro, de bordes irregulares y deprimidos en las plantas adultas, produciendo el colapso de las plántulas y, ocasionalmente, la muerte de las mismas. Rhizoctonia solani se aisló de manera consistente de las plantas sintomáticas. Tras una identificación morfológica y molecular, la patogenicidad de los aislados se probó colocando discos de agar adyacentes al tallo de la planta en estados de tres o cuatro hojas verdaderas. En las plantas inoculadas se observó un oscurecimiento de la corona y la necrosis del tallo en todos los casos, síntomas que no mostraron las plantas control. Por otro lado, se comprobó la patogenicidad de los aislados en semillas no germinadas. Los cuatro aislados produjeron muerte de plántulas cuando se inocularon en semillas no germinadas. Hasta donde hemos podido comprobar, este trabajo parece ser la primera cita de muerte de plántulas de acelga causada por R. solani en Europa
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