Development of improved plastic foam generating agents and techniques for Saturn applications Final report, Jul. 1964 - Jun. 1965

Foam system compressive strength analysis, solid urethane castings to screen polymer systems, and prepolymer methods of foam preparation in plastic foam development for Saturn projec

Mixing phenomena in circular and rectangular cross-sectional T-mixers: Experimental and numerical assessment

In the present work, the mixing performance of square and circular cross-sectional millimetre-sized T-mixers was experimentally and numerically investigated. The pure dilution of non-reacting species (blue and yellow food dyes) and the chemical reaction of two-coloured reactants (i.e., strong acid and strong base with a pH indicator) were captured experimentally by adopting a low-cost colorimetric digital image analysis technique. Turbulence was modelled by k − ε model coupled with the β-PDF approach to account for turbulence-chemistry interactions. The circular cross-sectional T-mixer showed better mixing efficiency than the square one. Moreover, an even larger mixing performances were obtained by setting unbalanced fluid flow rates. To exploit the low computational demanding k − ε model, the Cε2 parameter was tuned, showing good reliability in describing the phenomena in the mixers. Mixing time estimations were based on both time averages and instantaneous quantities, and some possible limits of the approaches commonly adopted in the literature were identified

Cost-effectiveness of empagliflozin in heart failure patients irrespective of ejection fraction in England.

AIMS: Heart failure (HF) is a complex syndrome commonly categorized into two main phenotypes [left ventricular ejection fraction (LVEF) below or above 40%], and although empagliflozin is the first approved medication with proven clinical effectiveness for both phenotypes, its cost-effectiveness of treating the entire HF population remains unknown. METHODS: The analysis was performed utilizing two preexisting, LVEF phenotype-specific cost-effectiveness models to estimate the cost-effectiveness of empagliflozin in adults for the treatment of symptomatic chronic HF, irrespective of ejection fraction (EF). The results of the phenotype-specific models were combined using a population-weighted approach to estimate the deterministic and probabilistic incremental cost-effectiveness ratios (ICERs). RESULTS: Based on combined results, empagliflozin + standard of care (SoC) is associated with 6.13 life-years (LYs) and 3.92 quality-adjusted life-years (QALYs) compared with 5.98 LYs and 3.76 QALYs for SoC alone over a lifetime, resulting in an incremental difference of 0.15 LYs and 0.16 QALYs, respectively. Total lifetime healthcare costs per patient are £15 246 for empagliflozin + SoC and £13 982 for SoC giving an incremental difference of £1264. The ICER is £7757/QALY, which is substantially lower than the willingness-to-pay (WTP) of £30 000 per QALY used by NICE. The results of the probabilistic sensitivity analyses are in line with the deterministic results. CONCLUSION: Empagliflozin is the first efficacious, approved, and cost-effective treatment option for all HF patients, irrespective of EF. The combined ICER was consistently below the WTP threshold. Therefore, empagliflozin offers value for money for the treatment of the full HF population in England

Control of planar nonlinear guided waves and spatial solitons with a left-handed medium

The evidence that double negative media, with an effective negative permittivity, and an effective negative permeability, can be manufactured to operate at frequencies ranging from microwave to optical is ushering in a new era of metamaterials. They are referred to here as 'left-handed', even though a variety of names is evident from the literature. In anticipation of a demand for highly structured integrated practical waveguides, this paper addresses the impact of this type of medium upon waveguides that can be also nonlinear. After an interesting historical overview and an exposure of some straightforward concepts, a planar guide is investigated, in which the waveguide is a slab consisting of a left-handed medium sandwiched between a substrate and cladding that are simple dielectrics. The substrate and cladding display a Kerr-type nonlinear response. Because of the nonlinear properties of the Kerr media, the power flow direction can be controlled by the intensity of the electric field. A comprehensive finite-difference-time-domain (FDTD) analysis is presented that concentrates upon spatial soliton behaviour. An interesting soliton-lens arrangement is investigated that lends itself to a novel cancellation effect.Comment: 19 pages, 11 figure

Supporting Student Learning Toward Twenty-First-Century Skills Through Digital Storytelling

Peer reviewe

Possible solutions to problems in simulating huge microwave applicators

The simulation of huge microwave applicators evidence significant problems in both the computation and data pre/post processing. In this work, some possible solutions based on commercial and public domain software are indicated and discussed