DG-CST (Disease Gene Conserved Sequence Tags), a database of human�mouse conserved elements associated to disease genes

The identification and study of evolutionarily conserved genomic sequences that surround disease-related genes is a valuable tool to gain insight into the functional role of these genes and to better elucidate the pathogenetic mechanisms of disease. We created the DG-CST (Disease Gene Conserved Sequence Tags) database for the identification and detailed annotation of human–mouse conserved genomic sequences that are localized within or in the vicinity of human disease-related genes. CSTs are defined as sequences that show at least 70% identity between human and mouse over a length of at least 100 bp. The database contains CST data relative to over 1088 genes responsible for monogenetic human genetic diseases or involved in the susceptibility to multifactorial/polygenic diseases. DG-CST is accessible via the internet at http://dgcst.ceinge.unina.it/ and may be searched using both simple and complex queries. A graphic browser allows direct visualization of the CSTs and related annotations within the context of the relative gene and its transcripts

SEI Growth and Depth Profiling on ZFO Electrodes by Soft X-Ray Absorption Spectroscopy

The evolution of the solid electrolyte interface (SEI) in carbon‐coated ZnFe2O4 (ZFO‐C) anodes is studied by soft X‐ray absorption spectroscopy (XAS). Experiments probe locally the SEI growth in the 2–100 nm range, using both total electron (TEY) and total fluorescence (TFY) yield techniques. XAS analysis shows that the SEI grows preferentially around the ZFO‐C nanoparticles

Autoimmune liver disease in a sicilian woman.

Autoimmune hepatitis (AIH) is a chronic liver disease characterized by clinical features analogue to viral and non-autoimmune liver disorders, but with distinct sero-autoimmunologic properties. The disease results from a network of complex interactions involving genetic predisposition, triggering factors, autoantigens and immunoregulatory system. Diagnosis of AIH relies on positive autoantibodies determination and on liver core biopsy histological appearance. Corticosteroid and immunosuppressive drugs are generally useful in the treatment of disease. However, when inflammation cannot be controlled, progression from chronic hepatitis to cirrhosis is often observed and hepatocellular carcinoma may appear at the end stage. Here we reported a case of a woman, affected with AIH. The patient presented features of chronic liver disease of neither viral nor alcoholic aetiology. Serum evidence of hypertraminasemia, hypergammaglobulinemia and specific autoantibodies were the leading points to final diagnosis, which was validated by liver biopsy. The patient was, finally, successfully treated with steroids

THE ROLE OF BUTYRIC ACID AS A OPROTECTIVE AGENT AGAINST INFLAMMATORY BOWEL DISEASE

Inflammatory Bowel disease (IBD), such as Crohn's disease and ulcerative colitis, are pathologies characterized by a chronic inflammation of the gastrointestinal tract. Their etiopathogenesis is not yet fully understood. Immune system and heat shock proteins (HSPs) dysfunctions are considered to be among the most likely causes of these diseases. Butyrate is a short-chain fatty acid produced by intestinal microflora. It has a trophic, benefical and protective role in the colonic mucosa, and it also induces changes in Hsp levels and localization. It may therefore be a valuable complementary therapeutic agent when used alongside trraditional drugs (mesalazine and corticosteroids) to treat the production of butyrate in the endoluminal environment may promote clinical remission in IBD patients. Due to these characteristics, there has been keen interest in the use of butyrate as a novel therapeutic supplement in the recent years. The current findings need to be validated through further clinical trials to better define the bbiomolecular dynamics of butyrate in the colonocytes of IBD patients

Measurement of constant radius swept features in cultural heritage

none3The dimensional characterization of archaeological fragment is a very complex operation and could prove to be useful for identifying the presence of standard attributes in the ceramics found from a specific archaeological site, or for making comparisons and analysis of similarities or for studying ancient technologies used for manufacture of objects. The dimensional analysis of the fragments is now carried out manually with traditional measuring devices. Typically, the results obtained are inaccurate and non-repeatable measurements. This paper focuses on the dimensional characterization of a specific geometric class of features: the constant radius swept features (called here CRS features). Several archaeological features, such as rims, bases, decorative motifs, processing marks and grooves are referable from a geometric point of view to the class of CRS features. These are detail features, which may be very interesting for the investigation of some aspects related to the historical-archaeological classification of the find. CRS features are often found on worn, damaged (e.g. chipped) or fragmented objects; they are frequently characterized, from a geometric point of view, by free form surfaces and by a limited cross sectional extension. In some cases, CRS features can be of axially symmetrical geometry: this occurs quite frequently in the case of archaeological pottery. For all these reasons, it is often difficult to apply traditional manual methods for the quantitative dimensional characterization of CRS features. This paper describes an original methodology for the measurement of CRS features acquired by scanning technologies. The algorithmic implementation of this methodology, consisting of a suitable processing of the feature nodes, allows to carry out automatically the dimensional characterization of the feature.Di Angelo L., Di Stefano P., Morabito A.E.Di Angelo, L.; Di Stefano, P.; Morabito, A. E

Search for the optimal build direction in additive manufacturing technologies: A review

By additive manufacturing technologies, an object is produced deposing material layer by layer. The piece grows along the build direction, which is one of the main manufacturing parameters of Additive Manufacturing (AM) technologies to be set-up. This process parameter affects the cost, quality, and other important properties of the manufactured object. In this paper, the Objective Functions (OFs), presented in the literature for the search of the optimal build direction, are considered and reviewed. The following OFs are discussed: part quality, surface quality, support structure, build time, manufacturing cost, and mechanical properties. All of them are distinguished factors that are affected by build direction. In the first part of the paper, a collection of the most significant published methods for the estimation of the factors that most influence the build direction is presented. In the second part, a summary of the optimization techniques adopted from the reviewed papers is presented. Finally, the advantages and disadvantages are briefly discussed and some possible new fields of exploration are proposed

Preliminary checklist of the Italian gypsophilous flora

The richness and uniqueness of the flora growing on gypsum substrates in Italy is known since the XIX century (Macchiati, 1888). Furthermore, the concept of plant gypsophily can be defined as the exclusiveness (or virtually exclusiveness) for living in gypsum outcropping rocks. Thus only those plant species, which show preference – or even exclusivity - for gypsum substrates, would be classified as gipsophilous (Mota et al., 2011). The main aim of this research has been the elaboration of a checklist of the Italian gypsophilous flora. The study was made possible through international collaboration between the "Mediterranea" University of Reggio Calabria (Italy) and the University of Almería (Spain). During the first step, an extensive literature review has been carried out in order to collect all available information about gypsophilous flora and to compile a preliminary list. Afterwards 18 regional botanists experts on Italian gypsum flora have been asked to rank the preference of these species for gypsum soils. Following the methodology proposed by Mota et al. (2009), the gypsophilous character of more than 100 plant species has been thus ranked on a scale ranging from 1 to 5 (with 5 representing for a total dependence on gypsum substrates). According to the obtained values, all the plant species, ranking between absolute or preferent gypsophytes, will figure in the final checklist of the gypsophytes of the whole Italian territory

Recognition of intrinsic quality properties for automatic geometric inspection

none3In the last few years the need for methodologies capable of performing an automated geometric inspection has increased. These methodologies often use 3D high-resolution optical digitisers to acquire points from the surface of the object to be inspected. It is expected that, in the near future, geometric inspection will be requiring more and more the use of these instruments. At present geometric inspection is not profiting from all the opportunities attainable by 3D high-resolution optical scanners or from the numerous tools which can be used for processing the point cloud acquired from the inspected product. For some years now, these authors have been working on a new methodology for automatic tolerance inspection working from a 3D model acquired by optical digitisers. In this paper all the information recognisable in a scanned object is organised into a new data structure, called Recognised Geometric Model (RGM). The final aim is to define a representation of the inspected object for the automatic evaluation of the non-idealities pertaining to the form, orientation and location of the non-ideal features of the acquired object. The key concept of the proposed approach is the capability to recognise some intrinsic nominal properties of the acquired model. These properties are assumed as references to evaluate the non-idealities of the inspected object. With this approach the references of geometric inspection are searched for in the inspected object independently of a tolerance specification and of the availability of a 3D nominal representation. The high-level geometric information within RGM depends on the rules used for its identification. The capability to recognise specific categories of nominal references offers the possibility of introducing new tolerances to be specified. The proposed approach has been implemented in original software by means of which a specific test case has been analysed.openP. Di Stefano; L. Di Angelo; A.E. MorabitoP., Di Stefano; L., Di Angelo; Morabito, Ann