Study of Resistive Micromegas in a Mixed Neutron and Photon Radiation Field

The Muon ATLAS Micromegas Activity (MAMMA) focuses on the development and testing of large-area muon detectors based on the bulk-Micromegas technology. These detectors are candidates for the upgrade of the ATLAS Muon System in view of the luminosity upgrade of Large Hadron Collider at CERN (sLHC). They will combine trigger and precision measurement capability in a single device. A novel protection scheme using resistive strips above the readout electrode has been developed. The response and sparking properties of resistive Micromegas detectors were successfully tested in a mixed (neutron and gamma) high radiation field supplied by the Tandem accelerator, at the N.C.S.R. Demokritos in Athens. Monte-Carlo studies have been employed to study the effect of 5.5 MeV neutrons impinging on Micromegas detectors. The response of the Micromegas detectors on the photons originating from the inevitable neutron inelastic scattering on the surrounding materials of the experimental facility was also studied

Economic inequalities in the effectiveness of a primary care intervention for depression and suicidal ideation.

BACKGROUND: Economic disadvantage is associated with depression and suicide. We sought to determine whether economic disadvantage reduces the effectiveness of depression treatments received in primary care. METHODS: We conducted differential-effects analyses of the Prevention of Suicide in Primary Care Elderly: Collaborative Trial, a primary-care-based randomized, controlled trial for late-life depression and suicidal ideation conducted between 1999 and 2001, which included 514 patients with major depression or clinically significant minor depression. RESULTS: The intervention effect, defined as change in depressive symptoms from baseline, was stronger among persons reporting financial strain at baseline (differential effect size = -4.5 Hamilton Depression Rating Scale points across the study period [95% confidence interval = -8.6 to -0.3]). We found similar evidence for effect modification by neighborhood poverty, although the intervention effect weakened after the initial 4 months of the trial for participants residing in poor neighborhoods. There was no evidence of substantial differences in the effectiveness of the intervention on suicidal ideation and depression remission by economic disadvantage. CONCLUSIONS: Economic conditions moderated the effectiveness of primary-care-based treatment for late-life depression. Financially strained individuals benefited more from the intervention; we speculate this was because of the enhanced treatment management protocol, which led to a greater improvement in the care received by these persons. People living in poor neighborhoods experienced only temporary benefit from the intervention. Thus, multiple aspects of economic disadvantage affect depression treatment outcomes; additional work is needed to understand the underlying mechanisms

Polynomial Growth Harmonic Functions on Finitely Generated Abelian Groups

In the present paper, we develop geometric analytic techniques on Cayley graphs of finitely generated abelian groups to study the polynomial growth harmonic functions. We develop a geometric analytic proof of the classical Heilbronn theorem and the recent Nayar theorem on polynomial growth harmonic functions on lattices \mathds{Z}^n that does not use a representation formula for harmonic functions. We also calculate the precise dimension of the space of polynomial growth harmonic functions on finitely generated abelian groups. While the Cayley graph not only depends on the abelian group, but also on the choice of a generating set, we find that this dimension depends only on the group itself.Comment: 15 pages, to appear in Ann. Global Anal. Geo

A fluorescence microscopy-based protocol for volumetric measurement of lysolecithin lesion-associated de- and re-myelination in mouse brain

Lysolecithin injections into the white matter tracts of the central nervous system are a valuable tool to study remyelination, but evaluating the resulting demyelinating lesion size is challenging. Here, we present a protocol to consistently measure the volume of demyelination and remyelination in mice following brain lysolecithin injections. We describe serial sectioning of the lesion, followed by the evaluation of the demyelinated area in two-dimensional images. We then detail the computation of the volume using our own automated iPython script

The role of silent ischemia, the arrhythmic substrate and the short-long sequence in the genesis of sudden cardiac death

AbstractTo study the role of silent ischemia and the arrhythmic substrate in the genesis of sudden cardiac death, 67 patients were studied (mean age 62 ± 12 years). Of these, 14 patients (Group 1) had an in-hospital episode of ventricular tachycardia or fibrillation while wearing a 24 h Holter ambulatory electrocardiographic (ECG) monitor, 33 (Group II) had a documented episode of sustained ventricular tachycardia or fibrillation, or both, and 20 (Group III) had angina pectoris but no ventricular tachycardia or fibrillation. Eight Group I survivors underwent programmed electrical stimulation or ECG signal averaging, or both. All Group II patients underwent 24 h Holter monitoring and ECG signal averaging to detect late potentials before programmed electrical stimulation. Group III patients underwent both 24 h Holter recording and coronary angiography. The 24 h ECG tapes were analyzed for ST segment changes, prematurity index and characteristics of ventricular premature depolarizations. Any ST depression ≥1mm for >30 s was considered to be a reflection of silent ischemia, and the induction of ventricular tachycardia or fibrillation by programmed electrical stimulation or the presence of late potentials, or both, was considered to be a reflection of the arrhythmia substrate.Silent ischemia preceded ventricular tachycardia in only 2 (14%) of the 14 Group I patients. The prematurity index was <1 in only 18% of ventricular tachycardia episodes. However, 14 (64%) of 22 episodes of ventricular tachycardia in 9 (64%) of the 14 patients were initiated by a ventricular premature depolarization preceded by a short-long sequence (sinus beat-ventricular premature depolarization-sinus beat) with a ratio of 0.5 ± 0.1. Six (75%) of eight in-hospital survivors of ventricular tachycardia or fibrillation (Group 1) had an arrhythmic substrate. A significantly (p < 0.0001) higher percent of the 33 Group II patients had an arrhythmic substrate (93%) than had silent ischemic episodes (45%). Silent ischemia resulted in ventricular tachycardia in only 1(7%) of 15 Group II patients. There was no significant difference between the incidence of silent ischemia (45% versus 35%) and the extent of coronary artery disease between Groups II and III.It is concluded that: 1) Silent ischemia was not a major determinant of ventricular tachycardia. 2) Although silent ischemia was common in survivors of ventricular tachycardia or fibrillation, its incidence was not significantly different from that in patients with angina pectoris and no sustained ventricular arrhythmias. 3) A high percent of patients (75% to 93%) with ventricular tachycardia and fibrillation have an arrhythmic substrate. 4) In the absence of acute myocardial infarction, sudden cardiac death is frequently triggered by a ventricular premature depolarization, with a preceding short-long cycle that likely produces dispersion of refractoriness in the arrhythmic substrate

Weighted norm inequalities, off-diagonal estimates and elliptic operators. Part IV: Riesz transforms on manifolds and weights

This is the fourth article of our series. Here, we study weighted norm inequalities for the Riesz transform of the Laplace-Beltrami operator on Riemannian manifolds and of subelliptic sum of squares on Lie groups, under the doubling volume property and Gaussian upper bounds.Comment: 12 pages. Fourth of 4 papers. Important revision: improvement of main result by eliminating use of Poincar\'e inequalities replaced by the weaker Gaussian keat kernel bound

Kν10.1 K⁺ - channel plasma membrane discrete domain partitioning and its functional correlation in neurons

AbstractKV10.1 potassium channels are implicated in a variety of cellular processes including cell proliferation and tumour progression. Their expression in over 70% of human tumours makes them an attractive diagnostic and therapeutic target. Although their physiological role in the central nervous system is not yet fully understood, advances in their precise cell localization will contribute to the understanding of their interactions and function. We have determined the plasma membrane (PM) distribution of the KV10.1 protein in an enriched mouse brain PM fraction and its association with cholesterol- and sphingolipid-rich domains. We show that the KV10.1 channel has two different populations in a 3:2 ratio, one associated to and another excluded from Detergent Resistant Membranes (DRMs). This distribution of KV10.1 in isolated PM is cholesterol- and cytoskeleton-dependent since alteration of those factors changes the relationship to 1:4. In transfected HEK-293 cells with a mutant unable to bind Ca2+/CaM to KV10.1 protein, Kv10.1 distribution in DRM/non-DRM is 1:4. Mean current density was doubled in the cholesterol-depleted cells, without any noticeable effects on other parameters. These results demonstrate that recruitment of the KV10.1 channel to the DRM fractions involves its functional regulation

Scenarios for multiplicity distributions in pp collisions in the TeV energy region

Possible scenarios based on available experimental data and phenomenological knowledge of the GeV energy region are extended to the TeV energy region in the framework of the weighted superposition mechanism of soft and semi-hard events. KNO scaling violations, forward-backward multiplicity correlations, Hq vs. q oscillations and shoulder structures are discussed.Comment: 10 pages, 10 figures, talk given at "Focus on Multiplicity" (Bari, Italy, June 2004

Performance Studies of Micromegas Chambers for the New Small Wheel Upgrade Project

Micromegas, an abbreviation for Micro MEsh Gaseous Structure (MM), is a robust detector with excellent spatial resolution and high rate capability. An $R\&D$ activity, called Muon ATLAS MicroMegas Activity (MAMMA), was initiated in 2007 in order to explore the potential of the MM technology for use in the ATLAS experiment. After several years of prototyping and testing, the ATLAS collaboration has chosen the MM technology along with the small-strip Thin Gap Chambers (sTGC) for the upgrade of the inner muon station in the high-rapidity region, the so called New Small Wheel (NSW) upgrade project. It will employ eight layers of MM and eight layers of sTGC detectors per wheel. The NSW project requires fully efficient MM chambers, able to cope with the maximum expected rate of $15\,\mathrm{kHz/cm^2}$ featuring single plane spatial resolution better than $100\,\mu\mathrm{m}$. The MM detectors will cover a total active area of $\sim1200\,\mathrm{m^2}$ and will be operated in a moderate magnetic field with intensity up to $0.4\,\mathrm{T}$. Moreover, together with the precise tracking capability the NSW MM chambers will contribute to the ATLAS Level-1 trigger system. An extensive $R\&D$ program is ongoing to determine the best configuration that satisfies these requirements. Several tests have been performed on small ($10\times10\,\mathrm{cm^2}$) and medium ($1\times0.5\,\mathrm{m^2}$) size prototypes using medium ($1-5\,\mathrm{GeV/c}$) and high momentum ($120-150\,\mathrm{GeV/c}$) hadron beams at CERN. A brief overview of the results obtained from recent performance tests concerning the aspects discussed above is presented