146 research outputs found
Inconsistent stimulation of plasma ACTH through corticotropin-releasing factor in a patient with central Cushing's disease due to pituitary adenoma
Three uncommon findings were observed in a case of Cushing's disease due to macroadenoma: no suppression of plasma ACTH during an 8-mg dexamethasone test, a negative corticotropin-releasing factor test, and a normal X-ray of the sella turcica. Despite these findings, the diagnosis of pituitary was confirmed Cushing's syndrome by computerized tomography and a transphenoidal operation
Frustrated H-Induced Instability of Mo(110)
Using helium atom scattering Hulpke and L"udecke recently observed a giant
phonon anomaly for the hydrogen covered W(110) and Mo(110) surfaces. An
explanation which is able to account for this and other experiments is still
lacking. Below we present density-functional theory calculations of the atomic
and electronic structure of the clean and hydrogen-covered Mo(110) surfaces.
For the full adsorbate monolayer the calculations provide evidence for a strong
Fermi surface nesting instability. This explains the observed anomalies and
resolves the apparent inconsistencies of different experiments.Comment: 4 pages, 2 figures, submitted to PR
Modeling the electronic behavior of -LiV2O5: a microscopic study
We determine the electronic structure of the one-dimensional spin-1/2
Heisenberg compound -LiVO, which has two inequivalent vanadium
ions, V(1) and V(2), via density-functional calculations. We find a relative
V(1)-V(2) charge ordering of roughly . We discuss the influence of the
charge ordering on the electronic structure and the magnetic behavior. We give
estimates of the basic hopping matrix elements and compare with the most
studied -NaVO.Comment: Final version. To appear in Phys. Rev. Let
Low-Temperature Structure of the Quarter-Filled Ladder Compound alpha'-NaV2O5
The low-temperature (LT) superstructure of -NaVO was
determined by synchrotron radiation x-ray diffraction. Below the phase
transition temperature associated with atomic displacement and charge ordering
at 34K, we observed the Bragg peak splittings, which evidence that the LT
structure is monoclinic. It was determined that the LT structure is
with the space group where and
represent the high temperature orthorhombic unit cell. The valence estimation
of V ions according to the bond valence sum method shows that the V sites are
clearly separated into two groups of V and V with a
charge ordering pattern. This LT structure is consistent with resonant x-ray
and NMR measurements, and strikingly contrasts to the LT structure previously
reported, which includes V sites.Comment: 4 pages, 3 figures, 1 tabl
The H1 Forward Proton Spectrometer at HERA
The forward proton spectrometer is part of the H1 detector at the HERA
collider. Protons with energies above 500 GeV and polar angles below 1 mrad can
be detected by this spectrometer. The main detector components are
scintillating fiber detectors read out by position-sensitive photo-multipliers.
These detectors are housed in so-called Roman Pots which allow them to be moved
close to the circulating proton beam. Four Roman Pot stations are located at
distances between 60 m and 90 m from the interaction point.Comment: 20 pages, 10 figures, submitted to Nucl.Instr.and Method
Ab initio evaluation of the charge-ordering in
We report {\it ab initio} calculations of the charge ordering in
using large configurations interaction methods on
embedded fragments. Our major result is that the electrons of the
bridging oxygen of the rungs present a very strong magnetic character and
should thus be explicitly considered in any relevant effective model. The most
striking consequence of this result is that the spin and charge ordering differ
substantially, as differ the experimental results depending on whether they are
sensitive to the spin or charge density.Comment: 4 page
The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype
Abstract: Pathogenic variants in aminoacyl-tRNA synthetases (ARS1) cause a diverse spectrum of autosomal recessive disorders. Tyrosyl tRNA synthetase (TyrRS) is encoded by YARS1 (cytosolic, OMIM*603,623) and is responsible of coupling tyrosine to its specific tRNA. Next to the enzymatic domain, TyrRS has two additional functional domains (N-Terminal TyrRSMini and C-terminal EMAP-II-like domain) which confer cytokine-like functions. Mutations in YARS1 have been associated with autosomal-dominant Charcot-Marie-Tooth (CMT) neuropathy type C and a heterogenous group of autosomal recessive, multisystem diseases. We identified 12 individuals from 6 families with the recurrent homozygous missense variant c.1099C > T;p.(Arg367Trp) (NM_003680.3) in YARS1. This variant causes a multisystem disorder with developmental delay, microcephaly, failure to thrive, short stature, muscular hypotonia, ataxia, brain anomalies, microcytic anemia, hepatomegaly, and hypothyroidism. In silico analyses show that the p.(Arg367Trp) does not affect the catalytic domain responsible of enzymatic coupling, but destabilizes the cytokine-like C-terminal domain. The phenotype associated with p.(Arg367Trp) is distinct from the other biallelic pathogenic variants that reside in different functional domains of TyrRS which all show some common, but also divergent clinical signs [(e.g., p.(Phe269Ser)—retinal anomalies, p.(Pro213Leu)/p.(Gly525Arg)—mild ID, p.(Pro167Thr)—high fatality)]. The diverse clinical spectrum of ARS1-associated disorders is related to mutations affecting the various non-canonical domains of ARS1, and impaired protein translation is likely not the exclusive disease-causing mechanism of YARS1- and ARS1-associated neurodevelopmental disorders. Key messages: The missense variant p.(Arg367Trp) in YARS1 causes a distinct multisystem disorder.p.(Arg367Trp) affects a non-canonical domain with cytokine-like functions.Phenotypic heterogeneity associates with the different affected YARS1 domains.Impaired protein translation is likely not the exclusive mechanism of ARS1-associated disorders
Thermodynamics of Spin S = 1/2 Antiferromagnetic Uniform and Alternating-Exchange Heisenberg Chains
The magnetic susceptibility chi and specific heat C versus temperature T of
the spin-1/2 antiferromagnetic alternating-exchange (J1 and J2) Heisenberg
chain are studied for the entire range 0 \leq alpha \leq 1 of the alternation
parameter alpha = J2/J1. For the uniform chain (alpha = 1), detailed
comparisons of the high-accuracy chi(T) and C(T) Bethe ansatz data of Kluemper
and Johnston are made with the asymptotically exact low-T field theory
predictions of Lukyanov. QMC simulations and TMRG calculations of chi(alpha,T)
are presented. From the low-T TMRG data, the spin gap Delta(alpha)/J1 is
extracted for 0.8 \leq alpha \leq 0.995. High accuracy fits to all of the above
numerical data are obtained. We examine in detail the theoretical predictions
of Bulaevskii for chi(alpha,T) and compare them with our results. Our
experimental chi(T) and C(T) data for NaV2O5 single crystals are modeled in
detail. The chi(T) data above the spin dimerization temperature Tc = 34 K are
not in agreement with the prediction for the uniform Heisenberg chain, but can
be explained if there is a moderate ferromagnetic interchain coupling and/or if
J changes with T. By fitting the chi(T) data, we obtain Delta(T = 0) = 103(2)
K, alternation parameter delta(0) = (1 - alpha)/(1 + alpha) = 0.034(6) and
average exchange constant J(0) = 640(80) K. The delta(T) and Delta(T) are
derived from the data. A spin pseudogap with a large magnitude \approx 0.4
Delta(0) is consistently found just above Tc, which decreases with increasing
T. Analysis of our C(T) data indicates that at Tc, at least 77% of the entropy
change due to the transition at Tc and associated order parameter fluctuations
arise from the lattice and/or charge degrees of freedom and less than 23% from
the spin degrees of freedom.Comment: 53 two-column REVTeX pages, 50 embedded figures, 7 tables. Revisions
required due to incorrect Eq. (39) in Ref. 51 which gives the low-T
approximation for the specific heat of a S = 1/2 1D system with a spin gap;
no conclusions were changed. Additional minor revisions made. Phys. Rev. B
(in press
The Outer Tracker Detector of the HERA-B Experiment Part I: Detector
The HERA-B Outer Tracker is a large system of planar drift chambers with
about 113000 read-out channels. Its inner part has been designed to be exposed
to a particle flux of up to 2.10^5 cm^-2 s^-1, thus coping with conditions
similar to those expected for future hadron collider experiments. 13
superlayers, each consisting of two individual chambers, have been assembled
and installed in the experiment. The stereo layers inside each chamber are
composed of honeycomb drift tube modules with 5 and 10 mm diameter cells.
Chamber aging is prevented by coating the cathode foils with thin layers of
copper and gold, together with a proper drift gas choice. Longitudinal wire
segmentation is used to limit the occupancy in the most irradiated detector
regions to about 20 %. The production of 978 modules was distributed among six
different laboratories and took 15 months. For all materials in the fiducial
region of the detector good compromises of stability versus thickness were
found. A closed-loop gas system supplies the Ar/CF4/CO2 gas mixture to all
chambers. The successful operation of the HERA-B Outer Tracker shows that a
large tracker can be efficiently built and safely operated under huge radiation
load at a hadron collider.Comment: 28 pages, 14 figure
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