256 research outputs found
State of the art transparency: lessons from Europe and North America
This Special Issue of the Journal of Risk Research was initiated to increase the evidence base supporting critical understanding of the use and impacts of transparency as a policy tool in risk management and regulation in Europe and North America. The lead research articles and perspectives were initially presented at a two-day workshop supported by the Journal of Risk Research and its publisher Taylor and Francis, which took place in Lavandou, Provence, 19th - 20th June 2014. In this editorial we introduce the motivations for the special issue and offer a brief summary of the contribution of each article highlighting key intersections and points of concurrenc
Putative ligand binding sites of two functionally characterized bark beetle odorant receptors
Background: Bark beetles are major pests of conifer forests, and their behavior is primarily mediated via olfaction. Targeting the odorant receptors (ORs) may thus provide avenues towards improved pest control. Such an approach requires information on the function of ORs and their interactions with ligands, which is also essential for understanding the functional evolution of these receptors. Hence, we aimed to identify a high-quality complement of ORs from the destructive spruce bark beetle Ips typographus (Coleoptera, Curculionidae, Scolytinae) and analyze their antennal expression and phylogenetic relationships with ORs from other beetles. Using 68 biologically relevant test compounds, we next aimed to functionally characterize ecologically important ORs, using two systems for heterologous expression. Our final aim was to gain insight into the ligand-OR interaction of the functionally characterized ORs, using a combination of computational and experimental methods. Results: We annotated 73 ORs from an antennal transcriptome of I. typographus and report the functional characterization of two ORs (ItypOR46 and ItypOR49), which are responsive to single enantiomers of the common bark beetle pheromone compounds ipsenol and ipsdienol, respectively. Their responses and antennal expression correlate with the specificities, localizations, and/or abundances of olfactory sensory neurons detecting these enantiomers. We use homology modeling and molecular docking to predict their binding sites. Our models reveal a likely binding cleft lined with residues that previously have been shown to affect the responses of insect ORs. Within this cleft, the active ligands are predicted to specifically interact with residues Tyr84 and Thr205 in ItypOR46. The suggested importance of these residues in the activation by ipsenol is experimentally supported through site-directed mutagenesis and functional testing, and hydrogen bonding appears key in pheromone binding. Conclusions: The emerging insight into ligand binding in the two characterized ItypORs has a general importance for our understanding of the molecular and functional evolution of the insect OR gene family. Due to the ecological importance of the characterized receptors and widespread use of ipsenol and ipsdienol in bark beetle chemical communication, these ORs should be evaluated for their potential use in pest control and biosensors to detect bark beetle infestations
Sonoluminescing air bubbles rectify argon
The dynamics of single bubble sonoluminescence (SBSL) strongly depends on the
percentage of inert gas within the bubble. We propose a theory for this
dependence, based on a combination of principles from sonochemistry and
hydrodynamic stability. The nitrogen and oxygen dissociation and subsequent
reaction to water soluble gases implies that strongly forced air bubbles
eventually consist of pure argon. Thus it is the partial argon (or any other
inert gas) pressure which is relevant for stability. The theory provides
quantitative explanations for many aspects of SBSL.Comment: 4 page
Mechanisms for Stable Sonoluminescence
A gas bubble trapped in water by an oscillating acoustic field is expected to
either shrink or grow on a diffusive timescale, depending on the forcing
strength and the bubble size. At high ambient gas concentration this has long
been observed in experiments. However, recent sonoluminescence experiments show
that in certain circumstances when the ambient gas concentration is low the
bubble can be stable for days. This paper presents mechanisms leading to
stability which predict parameter dependences in agreement with the
sonoluminescence experiments.Comment: 4 pages, 3 figures on request (2 as .ps files
Effects of Bulk Viscosity in Non-linear Bubble Dynamics
The non-linear bubble dynamics equations in a compressible liquid have been
modified considering the effects of compressibility of both the liquid and the
gas at the bubble interface. A new bubble boundary equation has been derived,
which includes a new term resulted from the liquid bulk viscosity effects. The
influence of this term has been numerically investigated considering the
effects of water vapor and chemical reactions on the bubble evolution. The
results clearly indicate that the new term has an important damping role at the
collapse, so that its consideration decreases the amplitude of the bubble
rebounds after the collapse. This damping feature is more remarkable for higher
deriving pressures.Comment: 4 pages, 7 figure
Gauge Theories with Cayley-Klein and Gauge Groups
Gauge theories with the orthogonal Cayley-Klein gauge groups and
are regarded. For nilpotent values of the contraction
parameters these groups are isomorphic to the non-semisimple Euclid,
Newton, Galilei groups and corresponding matter spaces are fiber spaces with
degenerate metrics. It is shown that the contracted gauge field theories
describe the same set of fields and particle mass as gauge
theories, if Lagrangians in the base and in the fibers all are taken into
account. Such theories based on non-semisimple contracted group provide more
simple field interactions as compared with the initial ones.Comment: 14 pages, 5 figure
Theory of quantum radiation observed as sonoluminescence
Sonoluminescence is explained in terms of quantum radiation by moving
interfaces between media of different polarizability. In a stationary
dielectric the zero-point fluctuations of the electromagnetic field excite
virtual two-photon states which become real under perturbation due to motion of
the dielectric. The sonoluminescent bubble is modelled as an optically empty
cavity in a homogeneous dielectric. The problem of the photon emission by a
cavity of time-dependent radius is handled in a Hamiltonian formalism which is
dealt with perturbatively up to first order in the velocity of the bubble
surface over the speed of light. A parameter-dependence of the zero-order
Hamiltonian in addition to the first-order perturbation calls for a new
perturbative method combining standard perturbation theory with an adiabatic
approximation. In this way the transition amplitude from the vacuum into a
two-photon state is obtained, and expressions for the single-photon spectrum
and the total energy radiated during one flash are given both in full and in
the short-wavelengths approximation when the bubble is larger than the
wavelengths of the emitted light. It is shown analytically that the spectral
density has the same frequency-dependence as black-body radiation; this is
purely an effect of correlated quantum fluctuations at zero temperature. The
present theory clarifies a number of hitherto unsolved problems and suggests
explanations for several more. Possible experiments that discriminate this from
other theories of sonoluminescence are proposed.Comment: Latex file, 28 pages, postscript file with 3 figs. attache
The Sound of Sonoluminescence
We consider an air bubble in water under conditions of single bubble
sonoluminescence (SBSL) and evaluate the emitted sound field nonperturbatively
for subsonic gas-liquid interface motion. Sound emission being the dominant
damping mechanism, we also implement the nonperturbative sound damping in the
Rayleigh-Plesset equation for the interface motion. We evaluate numerically the
sound pulse emitted during bubble collapse and compare the nonperturbative and
perturbative results, showing that the usual perturbative description leads to
an overestimate of the maximal surface velocity and maximal sound pressure. The
radius vs. time relation for a full SBSL cycle remains deceptively unaffected.Comment: 25 pages; LaTex and 6 attached ps figure files. Accepted for
publication in Physical Review
Readout system test benches
We propose to develop and exploit versatile multi-purpose Personal Computer-based Test Benches to support the evaluation and design of the basic elements required for digital front-end readout and data transmission systems for an LHC experiment. These test benches will have modular hardware facilities for the operation of new readout system components under realistic conditions, and will implement advanced modern software engineering concepts. They will support components such as fast ADCs, hybrid fibre-optic transceivers, and the prototype VLSI systolic array and data-flow processors currently being developed in national research laboratories and by the emerging European HDTV industry. These efforts would also lay the foundations for projects involving the development of custom-designed VLSI circuits
Markov analysis of stochastic resonance in a periodically driven integrate-fire neuron
We model the dynamics of the leaky integrate-fire neuron under periodic
stimulation as a Markov process with respect to the stimulus phase. This avoids
the unrealistic assumption of a stimulus reset after each spike made in earlier
work and thus solves the long-standing reset problem. The neuron exhibits
stochastic resonance, both with respect to input noise intensity and stimulus
frequency. The latter resonance arises by matching the stimulus frequency to
the refractory time of the neuron. The Markov approach can be generalized to
other periodically driven stochastic processes containing a reset mechanism.Comment: 23 pages, 10 figure
- …