Revealing the large nuclear dust structures in NGC 1068 with MIDI/VLTI

To understand the relation between the small "obscuring torus" and dusty structures at larger scales (5-10 pc) in NGC 1068, we use ESO's Mid-Infrared Interferometer (MIDI) with the 1.8 m Auxiliary Telescopes to achieve the necessary spatial resolution (~ 20-100 millarcsec). We use the chromatic phases in the data to improve the spatial fidelity of the analysis. We present interferometric data for NGC 1068 obtained in 2007 and 2012. We find no evidence of source variability. Many (u,v) points show non-zero chromatic phases indicating significant asymmetries. Gaussian model fitting of the correlated fluxes and chromatic phases provides a 3-component best fit with estimates of sizes, temperatures and positions of the components. A large, warm, off-center component is required at a distance approximately 90 mas to the north-west at a PA ~ -18 deg. The dust at 5-10 pc in the polar region contributes 4 times more to the mid-infrared flux at 12 um than the dust located at the center. This dust may represent the inner wall of a dusty cone. If similar regions are heated by the direct radiation from the nucleus, then they will contribute substantially to the classification of many Seyfert galaxies as Type 2. Such a region is also consistent in other Seyfert galaxies (the Circinus galaxy, NGC 3783 and NGC 424).Comment: 21 pages, 10 figures; Accepted for publication on A&

The structure of the dusty cores of active galactic nuclei

Active galactic nuclei (AGN) have been extensively studied to understand the possible link between the growth of super-massive black holes (SMBHs) and the evolution of galaxies. Circumnuclear dust present in AGNs plays a major role in the unification theory of AGNs. The X-ray/Optical/UV light from the central engine is absorbed and re-emitted in the infrared by this circumnuclear dust. In this thesis, we take advantage of the relevant information provided by infrared interferometric observations to investigate the geometry and the properties of the dusty environment. We analyzed infrared interferometric measurements of the object NGC1068 and determined the geometry, composition and temperature profile of the nuclear dust in this object. We additionally performed an analysis of a set of local galaxies to trace the dominant direction of the infrared emission, where we find that polar elongations are common in Seyfert galaxies. Finally, we present a statistically analysis on a set of Seyfert galaxies to test the validity of the standard model of AGNs. We investigated the similarities of Seyfert galaxies by combining infrared interferometric observations with radiative transfer clumpy models.NWO, NOVA, CONACyTUBL - phd migration 201

NGC 1068: No change in the mid-IR torus structure despite X-ray variability

Context. Recent NuSTAR observations revealed a somewhat unexpected increase in the X-ray flux of the nucleus of NGC 1068. We expect the infrared emission of the dusty torus to react on the intrinsic changes of the accretion disk. Aims. We aim to investigate the origin of the X-ray variation by investigating the response of the mid-infrared environment. Methods. We obtained single-aperture and interferometric mid-infrared measurements and directly compared the measurements observed before and immediately after the X-ray variations. The average correlated and single-aperture fluxes as well as the differential phases were directly compared to detect a possible change in the structure of the nuclear emission on scales of $\sim$ 2 pc. Results. The flux densities and differential phases of the observations before and during the X-ray variation show no significant change over a period of ten years. Possible minor variations in the infrared emission are $\lesssim$ 8 %. Conclusions. Our results suggest that the mid-infrared environment of NGC 1068 has remained unchanged for a decade. The recent transient change in the X-rays did not cause a significant variation in the infrared emission. This independent study supports previous conclusions that stated that the X-ray variation detected by NuSTAR observations is due to X-ray emission piercing through a patchy section of the dusty region.Comment: 6 pages, 5 figures, 3 tables. Accepted for publication on A&

NGC 1068: No change in the mid-infrared torus structure despite X-ray variability

Context. Recent NuSTAR observations revealed a somewhat unexpected increase in the X-ray flux of the nucleus of NGC 1068. We expect the infrared emission of the dusty torus to react on the intrinsic changes of the accretion disk. Aims. We aim to investigate the origin of the X-ray variation by investigating the response of the mid-infrared environment. Methods. We obtained single-aperture and interferometric mid-infrared measurements and directly compared the measurements observed before and immediately after the X-ray variations. The average correlated and single-aperture fluxes as well as the differential phases were directly compared to detect a possible change in the structure of the nuclear emission on scales of ~2 pc. Results. The flux densities and differential phases of the observations before and during the X-ray variation show no significant change over a period of ten years. Possible minor variations in the infrared emission are ≲6%. Conclusions. Our results suggest that the mid-infrared environment of NGC 1068 has remained unchanged for a decade. The recent transient change in the X-rays did not cause a significant variation in the infrared emission. This independent study supports previous conclusions that stated that the X-ray variation detected by NuSTAR observations is due to X-ray emission piercing through a patchy section of the dusty region

COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Background: Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods: The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results: The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March–May 2020) and the second wave (October–December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions: This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.EPICOVIDEHA has received funds from Optics COMMITTM (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223)