Micronutrient recommendations for vulnerable groups in context of undernutrition, during the COVID-19 pandemic in Latin America

La crisis por COVID-19 (SARS-CoV-2) puede convertirse en una catástrofe alimentaria para Latinoamérica, aumentando las personas que padecen hambre de 135 a 265 millones, especialmente en Venezuela, Guatemala, Honduras, Haití y El Salvador, que ya enfrentaban crisis económicas y sanitarias. Este manuscrito presenta la posición de un grupo de expertos latinoamericanos sobre las recomendaciones de consumo y/o suplementación con vitamina A, C, D, zinc, hierro, folatos y micronutrientes múltiples, en contextos de desnutrición, para grupos vulnerables: mujeres embarazadas y lactantes, niñas y niños menores de 5 años y adultos mayores. Las recomendaciones buscan disminuir el impacto potencial que tendrá COVID-19 en el estado nutricional, durante la pandemia. La posición surge de la discusión de dichos expertos con base a la revisión de evidencia científica actual para estos grupos vulnerables. Está dirigida a tomadores de decisiones, encargados de políticas públicas, personal de salud y organismos de la sociedad civil. Después de la lactancia materna y una dieta suficiente en cantidad y calidad, la suplementación con los micronutrientes presentados, puede contribuir a prevenir y tratar enfermedades virales, reforzar el sistema inmune y reducir complicaciones. La lactancia materna con medidas de higiene respiratoria, el suministro de múltiples micronutrientes en polvo para niños desde los 6 meses hasta los 5 años y el aporte de hierro y folatos o micronutrientes múltiples para la embarazada, son estrategias comprobadas y eficaces que deben seguirse implementando en tiempos de COVID-19. Para los adultos mayores la suplementación con vitamina C, D y zinc puede estar indicada.The COVID-19 crisis (SARS-CoV-2) might transform into a food catastrophe in Latin America and would increase the number of people suffering from hunger from 135 to 265 million, particularly in Venezuela, Guatemala, Honduras, Haiti and El Salvador, already facing economic and health crises. This manuscript presents the position of a group of Latin American experts in nutrition for establishing the recommendations for consumption and / or supplementation with vitamin A, C, D, zinc, iron, folates and multiple micronutrients, in undernutrition contexts, for vulnerable population of pregnant and lactating women, children under 5 years and the elderly. The recommendations seek to decrease the potential impact that COVID-19 will have on nutritional status during the pandemic. The position arises from the discussion of the experts based on the review of current scientific evidence for these vulnerable groups. It aims to reach stakeholders, public policy makers, health personnel and civil society organizations. Only after breastfeeding and a sufficient diet in terms of quantity and quality, a supplementation with the micronutrients mentioned above can help prevent and treat viral diseases, strengthen the immune system and even reduce complications. Breastfeeding with respiratory higiene measures, the provision of multiple micronutrients powders for children from 6 moths to 5 years of age and the supply of iron and folates or multiple micronutrients tablets for pregnant women are proven and effective strategies that must continue to be implemented during COVID-19 pandemic. For older adults, supplementation with vitamin C, D and zinc might be indicated.publishedVersionFil: Bonvecchio Arenas, Anabelle. Instituto Nacional de Salud Pública; México.Fil: Bernal, Jennifer. Universidad Nacional de Colombia. Observatorio de Seguridad Alimentaria; Colombia.Fil: Herrera Cuenca, Marianella. Universidad Central de Venezuela; Venezuela.Fil: Herrera Cuenca, Marianella. Fundación Bengoa para la Alimentación y Nutrición, Venezuela.Fil: Flores Aldana, Mario. Instituto Nacional de Salud Pública; México.Fil: Gutiérrez, Marlén. Global Nutrition Professionals Consultancy; Venezuela.Fil: Irizarry, Laura. Oficina Regional para América Latina y el Caribe. Programa Mundial de Alimentos (WFP); Panamá.Fil: Lay Mendivil, Lina. Universidad Tecnológica de Panamá; Panamá.Fil: López Bautista, Fabiola. Universidad Nacional Autónoma de México; México.Fil: López Reyes, Marisol. Global Nutrition Professionals Consultancy; España.Fil: Mata, Claret. Universidad Central de Venezuela; Venezuela.Fil: Moliterno, Paula. Universidad de la República; Uruguay.Fil: Moyano, Daniela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina.Fil: Moyano, Daniela. Universidad Nacional de Córdoba. Secretaría de Extensión Universitaria; Argentina.Fil: Moyano, Daniela. Universidad Nacional de la Matanza; Argentina.Fil: Murillo, Diana. Oficina Regional para América Latina y el Caribe. Programa Mundial de Alimentos; Panamá.Fil: Pacheco Miranda, Selene. Instituto Nacional de Salud Pública; México.Fil: Palacios, Cristina. Florida International University; United States.Fil: Palomares, Lita. Universidad Peruana Cayetano Heredia; Perú.Fil: Páramo, Kenia. Instituto de Nutrición de Centroamérica y Panamá; Belice y Nicaragua.Fil: Pérez, Analy. Unison Health & Community Services Global Nutrition Professionals Consultancy; Canadá.Fil: Tijerina Walls, María Virginia. Nutrien Nutrición y Salud; México.Fil: Trak-Fellermeier, María Angélica. Florida International University. Global Nutrition Professionals Consultancy; United States.Fil: Venosa López, Mónica. Instituto Nacional de Salud Pública; México

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

A global initiative for ecological and evolutionary hologenomics

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