The solutions of the 3rd and 4th Clay Millennium problems

In this treatise I present the solutions of the third Clay Millennium problem in the computational complexity and the fourth Clay Millennium problem in classical fluid dynamics.Comment: arXiv admin note: text overlap with arXiv:1108.1165 by other author

GREEK ADULT POPULATION WITH SPECIFIC LEARNING DISABILITIES: EPIDEMIOLOGY, DEMOGRAPHICS, AND GENDER DIFFERENCES

The aim of this study was to collect information about demographic characteristics of a clinical sample of Greek adults with specific learning disabilities (SLD) who referred themselves for learning assessment in a State Certified Diagnostic Center. Greek adult population with SLD is under-researched and difficult to access. The sample comprised 132 Greek adults (66.7% males) meeting the Diagnostic and Statistical Manual of Mental Disorders criteria for SLD. Data were collected through self-report records and case records which included demographic information and learning assessments. Most of the participants came from urban areas and they were studying in post-secondary non-tertiary or in tertiary education. As regards the prevalence of the main types of SLD and their comorbidity our findings agree with international data. The demographic characteristics, such as educational level and employment status, are discussed within the Greek socio-cultural context

Brand-to-generic levetiracetam switch in patients with epilepsy in a routine clinical setting

Purpose: The therapeutic equivalence of generic and brand antiepileptic drugs, based on studies performed on healthy volunteers, has been questioned. We compare, in a routine clinical setting, brand versus generic levetiracetam (LEV) bioequivalence in patients with epilepsy and also the clinical efficacy and tolerability of the substitution. / Methods: A prospective, open-label, non-randomized, steady-state, multiple-dose, bioequivalence study was conducted in 12 patients with epilepsy (5 females), with a mean age of 38.4 ± 16.2 years. Patients treated with the brand LEV (Keppra; UCB Pharma) were closely followed for a four-week period and subsequently switched to a generic LEV (Pharmaten) and followed for another four-week period. Blood samples were collected at the end of each 4-week period, during a dose interval for each formulation, for LEV concentration measurements by liquid chromatography mass spectrometry. Steady-state area under the curve (AUC) and peak plasma concentration (Cmax) data were subjected to conventional average bioequivalence analysis. Secondary clinical outcomes, including seizure frequency and adverse events, were recorded. / Results: Patients had epilepsy for a mean period of 14.1 ± 10.6 years and the mean daily LEV dose was 2583.3 ± 763.7 mg. The mean AUC ± SD and Cmax ± SD was 288.4 ± 86.3 (mg/L) h and 37.8 ± 10.4 mg/L respectively for brand LEV and 319.2 ± 104.7 (mg/L) h and 41.6 ± 12.3 mg/L respectively for the generic LEV. Statistic analysis showed no statistical significant difference in bioequivalence. Also, no change in seizures frequency and/or adverse events was recorded. / Conclusions: In our clinical setting, generic LEV was determined to be bioequivalent to brand LEV. Furthermore, seizures frequency or/and adverse events were not affected upon switching from brand to generic LEV

O Corona, where art thou? eROSITA's view of UV-optical-IR variability-selected massive black holes in low-mass galaxies

Finding massive black holes (MBHs, $M_{BH}\approx10^4-10^7 M_{\odot}$) in the nuclei of low-mass galaxies ($M_{*}\lessapprox10^{10} M_{\odot}$) is crucial to constrain seeding and growth of black holes over cosmic time, but it is particularly challenging due to their low accretion luminosities. Variability selection via long-term photometric ultraviolet, optical, or infrared (UVOIR) light curves has proved effective and identifies lower-Eddington ratios compared to broad and narrow optical spectral lines searches. In the inefficient accretion regime, X-ray and radio searches are effective, but they have been limited to small samples. Therefore, differences between selection techniques have remained uncertain. Here, we present the first large systematic investigation of the X-ray properties of a sample of known MBH candidates in dwarf galaxies. We extracted X-ray photometry and spectra of a sample of $\sim200$ UVOIR variability-selected MBHs and significantly detected 17 of them in the deepest available \emph{SRG}/eROSITA image, of which four are newly discovered X-ray sources and two are new secure MBHs. This implies that tens to hundreds of LSST MBHs will have SRG/eROSITA counterparts, depending on the seeding model adopted. Surprisingly, the stacked X-ray images of the many non-detected MBHs are incompatible with standard disk-corona relations, typical of active galactic nuclei, inferred from both the optical and radio fluxes. They are instead compatible with the X-ray emission predicted for normal galaxies. After careful consideration of potential biases, we identified that this X-ray weakness needs a physical origin. A possibility is that a canonical X-ray corona might be lacking in the majority of this population of UVOIR-variability selected low-mass galaxies or that unusual accretion modes and spectral energy distributions are in place for MBHs in dwarf galaxies.Comment: Accepted for publication in A&

Evaluation of performance at experimental buildings and real demonstration sites in BFIRST project: Theoretical and practical aspects for BIPV monitoring system

Monitoring is one of the main activity of BFIRST, Building-integrated FIbre-Reinforced Solar Technology, project, a 5 years funded European project, project reference number 29601, that started in April 2102 and deals with the design, development and demonstration of a portfolio of innovative photovoltaic products for building integration, based on cell encapsulation within fibre-reinforced composite materials. Automatic data acquisition systems are generally required for monitoring, performance evaluation and exchanging data of PV systems. Standard IEC 61724:1998 “Photovoltaic system performance monitoring –Guidelines for measurement, data exchange and analysis” provides a guideline that shall be followed in these cases. As far as Building Integrated Photovoltaics (BIPV) are considered, besides electrical parameters there is in addition the need to monitor the specific building performances. That is because a BIPV module operates as a multi-functional building construction material; it generates energy and serves as part of the building envelope. Since the building related performances are not included in the aforementioned IEC standard, a general guideline for monitoring was prepared within the project that has been used within the project at two levels: one at experimental sites mainly related to experimental single module testing and the other at demosite with real PV size plants

RoboPol: AGN polarimetric monitoring data

We present uniformly reprocessed and re-calibrated data from the RoboPol programme of optopolarimetric monitoring of active galactic nuclei (AGN), covering observations between 2013, when the instrument was commissioned, and 2017. In total, the dataset presented in this paper includes 5068 observations of 222 AGN with Dec > -25 deg. We describe the current version of the RoboPol pipeline that was used to process and calibrate the entire dataset, and we make the data publicly available for use by the astronomical community. Average quantities summarising optopolarimetric behaviour (average degree of polarization, polarization variability index) are also provided for each source we have observed and for the time interval we have followed it.Comment: Accepted to MNRA

Pushing the high count rate limits of scintillation detectors for challenging neutron-capture experiments

One of the critical aspects for the accurate determination of neutron capture cross sections when combining time-of-flight and total energy detector techniques is the characterization and control of systematic uncertainties associated to the measuring devices. In this work we explore the most conspicuous effects associated to harsh count rate conditions: dead-time and pile-up effects. Both effects, when not properly treated, can lead to large systematic uncertainties and bias in the determination of neutron cross sections. In the majority of neutron capture measurements carried out at the CERN n\_TOF facility, the detectors of choice are the C$_{6}$D$_{6}$ liquid-based either in form of large-volume cells or recently commissioned sTED detector array, consisting of much smaller-volume modules. To account for the aforementioned effects, we introduce a Monte Carlo model for these detectors mimicking harsh count rate conditions similar to those happening at the CERN n\_TOF 20~m fligth path vertical measuring station. The model parameters are extracted by comparison with the experimental data taken at the same facility during 2022 experimental campaign. We propose a novel methodology to consider both, dead-time and pile-up effects simultaneously for these fast detectors and check the applicability to experimental data from $^{197}$Au($n$,$\gamma$), including the saturated 4.9~eV resonance which is an important component of normalization for neutron cross section measurements