Analisis Tingkat Kepuasan Pelanggan Terhadap Pelayanan Apotek Kimia Farma Jakarta Menggunakan Model Servqual (Studi Kasus Pada Tiga Apotek)

Since policy sector pharmaceutical affairs 1993 by government about deregulations sector community pharmacy, competition business community pharmacy in Jakarta was very strict. For win something this competitions, Kimia Farma communitypharmacy as the biggest community pharmacy network in Indonesia have propagan-dized vision be the foremost business networking community pharmacy in Indonesiaand mission first-rate services for customers with customer satisfaction. The objec-tive of this research is detect satisfaction level of service quality of Kimia Farma community pharmacy Jakarta, in particular Kimia Farma community pharmacy -1Kemayoran, Kimia Farma community pharmacy-48 Matraman, Kimia Farma com-munity pharmacy-147 Duren Sawit. Beside This research also objective for knowed vision, mission of Kimia Farma community pharmacy was reached. This researchusing survey method with quisionaire Single Cross Sectional Study approaches.Research using Servqual (Service Quality) model was  discovered by Parasuraman, Zeithaml and Berry use five dimensions of service quality, that was tangible, reli-ability, responsiveness, assurance, and emphaty. Satisfaction level measured with Gap analysis that was difference expectation before customer receiving the service and perception after that; and Cartesian Diagram analysis, that was mapping atributservice quality on Cartesian Diagram. Analysis difference on customer satisfaction within community pharmacy used analysis varian (Anova). Result: dimension that highest satisfaction level was emphaty (gap -0.37 or satisfactions levels 91.88 %);attribute that highest satisfaction level was well designed interior/exterior building (gap -0.14 or satisfaction levels 96.4 %). Mapping attribute on Cartesian Diagram majority on quadrat B, means service quality Kimia Farma community pharmacy was sufficient. Based on hypothesis test, was not difference significant satisfactions level Kimia Farma community pharmacy was research (alpha > 0.05). Conclusions:generally satisfactions level Kimia Farma community pharmacy that researched nearly satisfy, with satisfaction levels within community pharmacy was not significant difference

Real-Time Temporal Dynamics of Bicistronic Expression Mediated by Internal Ribosome Entry Site and 2A Cleaving Sequence

Multicistronic elements, such as the internal ribosome entry site (IRES) and 2A-like cleavage sequence, serve crucial roles in the eukaryotic ectopic expression of exogenous genes. For utilization of multicistronic elements, the cleavage efficiency and order of elements in multicistronic vectors have been investigated; however, the dynamics of multicistronic element-mediated expression remains unclear. Here, we investigated the dynamics of encephalomyocarditis virus (EMCV) IRES- and porcine teschovirus-1 2A (p2A)-mediated expression. By utilizing real-time fluorescent imaging at a minute-level resolution, we monitored the expression of fluorescent reporters bridged by either EMCV IRES or p2A in two independent cultured cell lines, HEK293 and Neuro2a. We observed significant correlations for the two fluorescent reporters in both multicistronic elements, with a higher correlation coefficient for p2A in HEK293 but similar coefficients for IRES-mediated expression and p2A-mediated expression in Neuro2a. We further analyzed the causal relationship of multicistronic elements by convergent cross mapping (CCM). CCM revealed that in all four conditions examined, the expression of the preceding gene causally affected the dynamics of the subsequent gene. As with the cross correlation, the predictive skill of p2A was higher than that of IRES in HEK293, while the predictive skills of the two multicistronic elements were indistinguishable in Neuro2a. To summarize, we report a significant temporal correlation in both EMCV IRES- and p2A-mediated expression based on the simple bicistronic vector and real-time fluorescent monitoring. The current system also provides a valuable platform to examine the dynamic aspects of expression mediated by diverse multicistronic elements under various physiological conditions.National Research Foundation of Korea (NRF) of the Ministry of Science and ICT [NRF-2017R1C1B2008775, NRF-2017R1A4A1015534, NRF-2018M3C7A1022310]; KBRI basic research program through Korea Brain Research Institute - Ministry of Science and ICT [17-BR-04]Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Successful Magnetic Resonance Imaging-Guided Focused Ultrasound Surgery for Recurrent Uterine Fibroid Previously Treated with Uterine Artery Embolization

A 45-year-old premenopausal woman was referred to our clinic due to recurring symptoms of uterine fibroids, nine years after a uterine artery embolization (UAE). At the time of screening, the patient presented with bilateral impairment and narrowing of the uterine arteries, which increased the risk of arterial perforation during repeated UAE procedures. The patient was subsequently referred for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) treatment. Following the treatment, the patient experienced a significant improvement in symptoms (symptom severity score was reduced from 47 to 12 by 1 year post-treatment). MR images at 3 months showed a 49% decrease in fibroid volume. There were no adverse events during the treatment or the follow-up period. This case suggests that MRgFUS can be an effective treatment option for patients with recurrent fibroids following previous UAE treatment

Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress

Endoplasmic reticulum stress-mediated apoptosis plays an important role in the destruction of pancreatic β-cells and contributes to the development of type 1 diabetes. The present study examined the effect of KIOM-4, a mixture of four plant extracts, on streptozotocin- (STZ-) induced endoplasmic reticulum (ER) stress in rat pancreatic β-cells (RINm5F). KIOM-4 was found to inhibit STZ-induced apoptotic cell death, confirmed by formation of apoptotic bodies and DNA fragmentation. STZ was found to induce the characteristics of ER stress; mitochondrial Ca2+ overloading, enhanced ER staining, release of glucose-regulated protein 78 (GRP78), phosphorylation of RNA-dependent protein kinase (PKR) like ER kinase (PERK) and eukaryotic initiation factor-2α (eIF-2α), cleavage of activating transcription factor 6 (ATF6) and caspase 12, and upregulation of CCAAT/enhancer-binding protein-homologous protein (CHOP). However, KIOM-4 attenuated these changes induced by STZ. Furthermore, KIOM-4 suppressed apoptosis induced by STZ in CHOP downregulated cells using CHOP siRNA. These results suggest that KIOM-4 exhibits protective effects in STZ-induced pancreatic β-cell damage, by interrupting the ER stress-mediated pathway

Effects of Maxillary Sinus Graft on the Survival of Endosseous Implants: A 10-Year Retrospective Study

Purpose: The aim of this study was to determine the survival rates of implants placed in grafted maxillary sinuses and compare the results obtained with graft materials, implant surfaces and timing of implant placement. Materials and Methods: Between January 1996 and December 2005, 391 implants are placed in 161 patients who underwent sinus grafting treatment simultaneously or separately at Ewha Womans University Hospital. According to inclusion critieria, 272 impants were placed in 102 patients with 112 sinus grafts (30 females, 72 males), aged 26 to 88 years (mean age 49.0±9.7). The follow-up period ranged from 12 to 134 months (mean F/U 47±32). Survival rates were evaluated according to graft material, implant surface and timing of implant placement, The Kaplan-Meier procedure and the log rank (Mantel-Cox) test were used to estimate survival rates and test for equality of survival rates between different groups of patients. Results: Ten-year cumultative survival rate for implants placed in the grafted sinuses was 90.1%. The survival rates for autogenous bone, combination and bone substitutes were 94.6%, 85.9% and 100% respectively (p\u3e0.05). According to implant surface, survival rates were 84.8% in machined group and 97.5% in rough group (p0.05). Conclusion: Ten-year cumultative survival rate for implants placed in the grafter sinuses was 90.1% Rough-shaped implants have a higher survival rate than machined-surface implants when placed in grafted sinuses. (p\u3c0.05)

In-situ analysis of fiber structure development for isotactic polypropylene

Structural development of isotactic polypropylene (iPP) fibers was analyzed in real time through in-situ WAXD/SAXS and fiber temperature measurements during CO(2) laser-heated drawing because the CO(2) laser irradiation can nearly fix the necking position on the running fiber. The in-situ WAXD/SAXS measurements were carried out with a high time-resolution of 0.4 ms. The as-spun iPP fibers of two different initial structures were laser-heat-drawn to a draw ratio of 6.5. For the drawing of PP fiber containing mesophase structure, diffraction from the oriented mesophase remained until an elapsed time of 1.0 ms, when oriented alpha-phase crystal started to form. Meanwhile, for the drawing of PP fiber containing both an alpha-phase and a mesophase structure, fragmented microcrystals were reorganized by orientation-induced crystallization before an elapsed time of 1.0 ms. The long period increased drastically with fragmentation, and decreased with reorganization. The long period was about 16 nm for both drawn fibers.ArticlePOLYMER. 52(9):2044-2050 (2011)journal articl

Effect of drawing stress on mesophase structure formation of poly(ethylene 2,6-naphthalene dicarboxylate) fiber just after the neck-drawing point

The structural development of poly(ethylene 2,6-naphthalene dicarboxylate) (PEN) fibers was analyzed by in situ X-ray diffraction and fiber temperature measurements. The PEN fiber was drawn continuously under three drawing stresses, where the neck-drawing point was fixed accurately by CO2 laser irradiation heating. The developed crystal structures of the drawn fibers depended on the drawing stresses, that is, only the alpha-crystal was obtained under a drawing stress of 148 MPa, an alpha-rich mixed crystal was obtained for 54 MPa, and a beta-rich mixed crystal was obtained under 23 MPa stress. Fiber containing over 70% beta-crystal was obtained in the third case. Orientation-induced crystallization rates (K) and crystallization induction times (t(0)) were estimated for the three drawing stresses: K = 2210 s(-1) and t(0) = 0.5 ms for 148 MPa, K = 940 s(-1) and t(0) = 1.0 ms for 54 MPa, and K= 655 s(-1) and t(0) = 4.0 ms for 23 MPa. In addition, the drawing stress acted as a definitive influence not only on the resulting crystal form but also on the chain conformation of the mesophase structure. The d-spacing of the (001') diffraction increased with drawing stress, and the longer (001') spacing generated the alpha-crystal while the comparatively shorter (001') spacing yielded the beta-crystal. The d-spacings of 1.27 and 1.23 nm for the drawing stresses of 148 and 23 MPa, respectively, were somewhat shorter than the c-axis lengths of the alpha- and beta-crystals of 1.32 and 1.27 nm, respectively.ArticlePOLYMER. 53(19):4272-4279 (2012)journal articl