Власнi частоти та власнi форми регулярних ланцюгових коливальних систем

The classical approach in the investigation of natural oscillations of discrete mechanical oscillatingsystems is the solution of the secular equation for finding the eigenfrequencies and the system of algebraic equations for determining the amplitude coefficients (eigenforms). However, the analytical solution of the secular equation is possible only for a limited class of discrete systems, especially with a finite degree of freedom. This class includes regular chain oscillating systems in which the same oscillators are connected in series. Regular systems are divided into systems with rigidly fixed ends, with one or both free ends, which significantly affects the search for eigenfrequencies and eigenforms. This paper shows how, having a solution for the secular equation of a regular system with rigidly fixed ends, it is possible to determine the eigenfrequencies and eigenforms of regular systems with one or both free ends. Pages of the article in the issue: 88 - 93 Language of the article: UkrainianКласичним пiдходом при дослiдженнi власних коливань дискретних коливальних механiчних систем є розв’язання вiкового рiвняння для знаходження власних частот та системи алгебраїчних рiвнянь для визначення амплiтудних коефiцiєнтiв. Однак, аналiтичне розв’язання вiкового рiвняння можливе тiльки для обмеженого кола дискретних систем, особливо зi скiнченним ступенем вiльностi. До такого класу вiдносяться регулярнi ланцюговi коливальнi системи, в яких однаковi осцилятори з’єднанi мiж собою послiдовно. Регулярнi системи роздiляються на системи з жорстко закрiпленими кiнцями, з одним або обома вiльними кiнцями, що суттєво впливає на пошук власних частот та власних форм. В данiй статтi показано, як маючи розв’язок для вiкового рiвняння регулярної системи з жорстко закрiпленими кiнцями, можна визначити власнi частоти та власнi форми регулярних систем з одним чи обома вiльними кiнцями

Векторно-алгебраїчний пiдхiд до кiнематичного аналiзу структурних груп 2-го класу за Артоболевським

The methodology for analyzing velocities and accelerations of characteristic points, as well as angular velocities and angular accelerations of links, of the structural groups of the 2nd class according to Artobolevsky is developed using exclusively the tools of vector algebra. There are exist five forms of the structural groups of the 2nd class by Artobolevsky, each form has been considered. The position analyses of the structural groups, which are described by the links’ direction vectors and the radius-vectors of points of external kinematic pairs, and in addition, if necessary, the position analysis of external links are assumed to have been carried out by the vector algebra or some other approach. Provided for all forms of the structural groups formulas for calculations are prepared for creating a software product that automatizes the kinematic analysis of planar linkages of the 2nd class according to Artobolevsky. Also, they can be used for the kinetostatic and dynamic analyses of the mentioned linkages. The specified limits of application of the presented approach are pointed out. Pages of the article in the issue: 160 - 163 Language of the article: EnglishРозроблена методика проведення кiнематичного аналiзу структурних груп 2-го класу за Артоболевським за допомогою виключно iнструментарiю векторної алгебри. Плани положень структурних груп, а за необхiдностi, i зовнiшнiх до них ланок, вважаються виконаними будь-яким пiдходом. Наведенi формули для обчислень, якi можуть бути використанi для кiнематичного, кiнетостатичного та динамiчного аналiзу плоских важiльних механiзмiв 2-го класу за Артоболевським, вказанi межi їх використання

Application of serex-analysis for identification of human colon cancer antigens

Copyright © Experimental Oncology, 2015. Background: Colorectal, lung and breast tumors are the most devastating and frequent malignances in clinical oncology. SEREX-analysis of colon cancer leads to identification of more than hundred antigens which are potential tumor markers. With idea that immunoscreening with pool of allogeneic sera is more productive for antigen isolation, SEREX-analysis was applied to four cases of stages II-IV primary colon tumor and 22 new antigens were isolated. Objective: To characterize 22 primary colon cancer antigens isolated by SEREXtechnique. Materials and Methods: Allogenic screening, real-time PCR analysis. Results: After allogeneic immunoscreening, for 5 of 22 (22%) isolated antigens were confirmed colon cancer restricted serological profile solely positive for 14% of tested colon cancer sera. Through these five antigens, KY-CC-17/β-actin has cytoskeleton function; KY-CC-14/ACTR1A and KY-CC-19/TSGA2 participate in chromosome segregation; KY-CC-12/FKBP4 regulates steroid receptor function and KY-CC-15/PLRG1 is a component of spliceosome complex. For the last four antigens tested were found aberrant mRNA expression in some cases of colon tumor. Conclusion: The exploration of identified antigens may define suitable targets for immunotherapy or diagnostic of colon cancer

Application of serex-analysis for identification of human colon cancer antigens

Copyright © Experimental Oncology, 2015. Background: Colorectal, lung and breast tumors are the most devastating and frequent malignances in clinical oncology. SEREX-analysis of colon cancer leads to identification of more than hundred antigens which are potential tumor markers. With idea that immunoscreening with pool of allogeneic sera is more productive for antigen isolation, SEREX-analysis was applied to four cases of stages II-IV primary colon tumor and 22 new antigens were isolated. Objective: To characterize 22 primary colon cancer antigens isolated by SEREXtechnique. Materials and Methods: Allogenic screening, real-time PCR analysis. Results: After allogeneic immunoscreening, for 5 of 22 (22%) isolated antigens were confirmed colon cancer restricted serological profile solely positive for 14% of tested colon cancer sera. Through these five antigens, KY-CC-17/β-actin has cytoskeleton function; KY-CC-14/ACTR1A and KY-CC-19/TSGA2 participate in chromosome segregation; KY-CC-12/FKBP4 regulates steroid receptor function and KY-CC-15/PLRG1 is a component of spliceosome complex. For the last four antigens tested were found aberrant mRNA expression in some cases of colon tumor. Conclusion: The exploration of identified antigens may define suitable targets for immunotherapy or diagnostic of colon cancer

Application of serex-analysis for identification of human colon cancer antigens

Copyright © Experimental Oncology, 2015. Background: Colorectal, lung and breast tumors are the most devastating and frequent malignances in clinical oncology. SEREX-analysis of colon cancer leads to identification of more than hundred antigens which are potential tumor markers. With idea that immunoscreening with pool of allogeneic sera is more productive for antigen isolation, SEREX-analysis was applied to four cases of stages II-IV primary colon tumor and 22 new antigens were isolated. Objective: To characterize 22 primary colon cancer antigens isolated by SEREXtechnique. Materials and Methods: Allogenic screening, real-time PCR analysis. Results: After allogeneic immunoscreening, for 5 of 22 (22%) isolated antigens were confirmed colon cancer restricted serological profile solely positive for 14% of tested colon cancer sera. Through these five antigens, KY-CC-17/β-actin has cytoskeleton function; KY-CC-14/ACTR1A and KY-CC-19/TSGA2 participate in chromosome segregation; KY-CC-12/FKBP4 regulates steroid receptor function and KY-CC-15/PLRG1 is a component of spliceosome complex. For the last four antigens tested were found aberrant mRNA expression in some cases of colon tumor. Conclusion: The exploration of identified antigens may define suitable targets for immunotherapy or diagnostic of colon cancer

Application of serex-analysis for identification of human colon cancer antigens

Copyright © Experimental Oncology, 2015. Background: Colorectal, lung and breast tumors are the most devastating and frequent malignances in clinical oncology. SEREX-analysis of colon cancer leads to identification of more than hundred antigens which are potential tumor markers. With idea that immunoscreening with pool of allogeneic sera is more productive for antigen isolation, SEREX-analysis was applied to four cases of stages II-IV primary colon tumor and 22 new antigens were isolated. Objective: To characterize 22 primary colon cancer antigens isolated by SEREXtechnique. Materials and Methods: Allogenic screening, real-time PCR analysis. Results: After allogeneic immunoscreening, for 5 of 22 (22%) isolated antigens were confirmed colon cancer restricted serological profile solely positive for 14% of tested colon cancer sera. Through these five antigens, KY-CC-17/β-actin has cytoskeleton function; KY-CC-14/ACTR1A and KY-CC-19/TSGA2 participate in chromosome segregation; KY-CC-12/FKBP4 regulates steroid receptor function and KY-CC-15/PLRG1 is a component of spliceosome complex. For the last four antigens tested were found aberrant mRNA expression in some cases of colon tumor. Conclusion: The exploration of identified antigens may define suitable targets for immunotherapy or diagnostic of colon cancer

Eigenfrequencies and eigenforms of regular chain oscillatory systems

The classical approach in the investigation of natural oscillations of discrete mechanical oscillatingsystems is the solution of the secular equation for finding the eigenfrequencies and the system of algebraic equations for determining the amplitude coefficients (eigenforms). However, the analytical solution of the secular equation is possible only for a limited class of discrete systems, especially with a finite degree of freedom. This class includes regular chain oscillating systems in which the same oscillators are connected in series. Regular systems are divided into systems with rigidly fixed ends, with one or both free ends, which significantly affects the search for eigenfrequencies and eigenforms. This paper shows how, having a solution for the secular equation of a regular system with rigidly fixed ends, it is possible to determine the eigenfrequencies and eigenforms of regular systems with one or both free ends.</jats:p