Gating of memory encoding of time-delayed cross-frequency MEG networks revealed by graph filtration based on persistent homology

To explain gating of memory encoding, magnetoencephalography (MEG) was analyzed over multi-regional network of negative correlations between alpha band power during cue (cue-alpha) and gamma band power during item presentation (item-gamma) in Remember (R) and No-remember (NR) condition. Persistent homology with graph filtration on alpha-gamma correlation disclosed topological invariants to explain memory gating. Instruction compliance (R-hits minus NR-hits) was significantly related to negative coupling between the left superior occipital (cue-alpha) and the left dorsolateral superior frontal gyri (item-gamma) on permutation test, where the coupling was stronger in R than NR. In good memory performers (R-hits minus false alarm), the coupling was stronger in R than NR between the right posterior cingulate (cue-alpha) and the left fusiform gyri (item-gamma). Gating of memory encoding was dictated by inter-regional negative alpha-gamma coupling. Our graph filtration over MEG network revealed these inter-regional time-delayed cross-frequency connectivity serve gating of memory encoding

G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion

G-protein-coupled receptor 81 (GPR81) functions as a receptor for lactate and plays an important role in the regulation of anti-lipolytic effects in adipocytes. However, to data, a role for GPR81 in the tumor microenvironment has not been clearly defined. Here, GPR81 expression in breast cancer patients and several breast cancer cell lines was significantly increased compared with normal mammary tissues and cells. GPR81 knockdown resulted in impaired breast cancer growth and led to apoptosis both in vitro and in vivo. Furthermore, the inhibition of GPR81 signaling suppressed angiogenesis through a phosphoinositide 3-OH kinase (PI3K)/Akt-cAMP response element binding protein (CREB) pathway, which led to decreased production of the pro-angiogenic mediator amphiregulin (AREG). Overall, these findings identify GPR81 as a tumor-promoting receptor in breast cancer progression and suggest a novel mechanism that regulates GPR81-dependent activation of the PI3K/Akt signaling axis in tumor microenvironment.open

A Zero Velocity Detection Algorithm Using Inertial Sensors for Pedestrian Navigation Systems

In pedestrian navigation systems, the position of a pedestrian is computed using an inertial navigation algorithm. In the algorithm, the zero velocity updating plays an important role, where zero velocity intervals are detected and the velocity error is reset. To use the zero velocity updating, it is necessary to detect zero velocity intervals reliably. A new zero detection algorithm is proposed in the paper, where only one gyroscope value is used. A Markov model is constructed using segmentation of gyroscope outputs instead of using gyroscope outputs directly, which makes the zero velocity detection more reliable

Distance and Reddening of the Isolated Dwarf Irregular Galaxy NGC 1156

We present a photometric estimation of the distance and reddening values to the dwarf irregular galaxy NGC 1156, which is one of the best targets to study the isolated dwarf galaxies in the nearby universe. We have used the imaging data sets of the Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) High Resolution Channel (HRC) of the central region of NGC 1156 (26" X 29") available in the HST archive for this study. From the (U-B, B-V) color-color diagram, we first estimate the total (foreground + internal) reddening toward NGC 1156 of E(B-V) =0.35 +/- 0.05 mag, whereas only the foreground reddening was previously known to be E(B-V)=0.16 mag (Burstein & Heiles) or 0.24 mag (Schlegel, Finkbeiner, & Davis). Based on the brightest stars method, selecting the three brightest blue supergiant (BSG) stars with mean B magnitude of = 21.94 mag and the three brightest red supergiant (RSG) stars with mean V magnitude of = 22.76 mag, we derive the distance modulus to NGC 1156 to be (m-M)_{0,BSG} = 29.55 mag and (m-M)_{0,RSG} = 29.16 mag. By using weights of 1 and 1.5 for the distance moduli from using the BSGs and the RSGs, respectively, we finally obtain the weighted mean distance modulus to NGC 1156 (m-M)_0 = 29.39 +/- 0.20 mag (d = 7.6 +/- 0.7 Mpc), which is in very good agreement with the previous estimates. Combining the photometry data of this study with those of Karachentsev et al. gives smaller distance to NGC 1156, which is discussed together with the limits of the data.Comment: 18 pages, 8 figures, Accepted by PASJ (2012 Apr issue

Height Compensation Using Ground Inclination Estimation in Inertial Sensor-Based Pedestrian Navigation

In an inertial sensor-based pedestrian navigation system, the position is estimated by double integrating external acceleration. A new algorithm is proposed to reduce z axis position (height) error. When a foot is on the ground, a foot angle is estimated using accelerometer output. Using a foot angle, the inclination angle of a road is estimated. Using this road inclination angle, height difference of one walking step is estimated and this estimation is used to reduce height error. Through walking experiments on roads with different inclination angles, the usefulness of the proposed algorithm is verified