1,096 research outputs found
Cultural globalization and the Korean promotion policy for music based on tradition : a study of the activation plan and its background
Human dopamine receptor nanovesicles for gate-potential modulators in high-performance field-effect transistor biosensors
The development of molecular detection that allows rapid responses with high sensitivity and selectivity remains challenging. Herein, we demonstrate the strategy of novel bio-nanotechnology to successfully fabricate high-performance dopamine (DA) biosensor using DA Receptor-containing uniform-particle-shaped Nanovesicles-immobilized Carboxylated poly(3,4-ethylenedioxythiophene) (CPEDOT) NTs (DRNCNs). DA molecules are commonly associated with serious diseases, such as Parkinson's and Alzheimer's diseases. For the first time, nanovesicles containing a human DA receptor D1 (hDRD1) were successfully constructed from HEK-293 cells, stably expressing hDRD1. The nanovesicles containing hDRD1 as gate-potential modulator on the conducting polymer (CP) nanomaterial transistors provided high-performance responses to DA molecule owing to their uniform, monodispersive morphologies and outstanding discrimination ability. Specifically, the DRNCNs were integrated into a liquid-ion gated field-effect transistor (FET) system via immobilization and attachment processes, leading to high sensitivity and excellent selectivity toward DA in liquid state. Unprecedentedly, the minimum detectable level (MDL) from the field-induced DA responses was as low as 10 pM in real- time, which is 10 times more sensitive than that of previously reported CP based-DA biosensors. Moreover, the FET-type DRNCN biosensor had a rapid response time (<1 s) and showed excellent selectivity in human serum
New Classification of Polydactyly of the Foot on the Basis of Syndactylism, Axis Deviation, and Metatarsal Extent of Extra Digit
Background Polydactyly of the foot is one of the most frequent anomalies of the limbs.However, most classification systems are based solely on morphology and tend to be inaccurate and lessrelevantto surgical methods and results. The purpose ofthisstudy isto presentour newclassification of polydactyly ofthe foot,which can serve as a predictor oftreatmentand prognosis.Methods To find a correlation between the various morphologic traits of polydactyly ofthe foot and the treatment plan and outcomes,we reviewed 532 cases of polydactyly ofthefoot in 431 patients treated in our hospital, expanding on our previous study that describedpolydactyly based on the importance of metatarsal bone status and varus deformity. Therecords of patientswere evaluated and comparedwith previousstudies at other centers.Results Unsatisfactory results were seen in 36 cases, which included 5 cases of incompleteseparation due to syndactylism, 23 cases of axis deviation, and 8 cases ofremnants of extradigit metatarsal bones. The locus of the polydactyly, or the digit which wasinvolved, did notseemto affectthe final postoperative outcomesin ourstudy. Three factorssyndactylism, axisdeviation, and metatarsal extensionare the major factors related to treatment strategy andprognosis. Therefore,we developed a newclassification systemusing three characters(S,A,M)followed by three groups(0, 1, 2),to describe the complexity of polydactyly ofthe foot,suchas S1A2M2.Conclusions Our newclassification could provide a communicable description to help determine the surgical plan and predict outcomes
Geomagnetic field influences probabilistic abstract decision-making in humans
To resolve disputes or determine the order of things, people commonly use
binary choices such as tossing a coin, even though it is obscure whether the
empirical probability equals to the theoretical probability. The geomagnetic
field (GMF) is broadly applied as a sensory cue for various movements in many
organisms including humans, although our understanding is limited. Here we
reveal a GMF-modulated probabilistic abstract decision-making in humans and the
underlying mechanism, exploiting the zero-sum binary stone choice of Go game as
a proof-of-principle. The large-scale data analyses of professional Go matches
and in situ stone choice games showed that the empirical probabilities of the
stone selections were remarkably different from the theoretical probability. In
laboratory experiments, experimental probability in the decision-making was
significantly influenced by GMF conditions and specific magnetic resonance
frequency. Time series and stepwise systematic analyses pinpointed the
intentionally uncontrollable decision-making as a primary modulating target.
Notably, the continuum of GMF lines and anisotropic magnetic interplay between
players were crucial to influence the magnetic field resonance-mediated
abstract decision-making. Our findings provide unique insights into the impact
of sensing GMF in decision-makings at tipping points and the quantum mechanical
mechanism for manifesting the gap between theoretical and empirical probability
in 3-dimensional living space.Comment: 32 pages, 5 figures, 4 supplementary figures, 2 supplementary tables,
and separate 15 ancillary file
일측성 구순열 환자에서 3차원 수치사진측량 스캔과 직접계측 방법의 비교
Background: In cleft lip patients, the necessity of a thorough preoperative analysis of facial deformities before reconstruction is unquestioned. The surgical plan of cleft lip patient is based on the information gained from our preoperative anthropometric evaluation. A variety of commercially available three-dimensional (3D) surface imaging systems are currently introduced to us in plastic surgery for these use. However, few studies have been published on the soft tissue morphology of unrepaired cleft infants described by these 3D surface imaging systems.Methods: The purpose of this study is to determine the accuracy of facial anthropometric measurements obtained through digital 3D photogrammetry and to compare with direct anthropometry for measurement in unilateral cleft lip patients. We compared our patients with three measurements of dimension made on both sides: heminasal width, labial height, and transverse lip length.Results: The preoperative measurements were not significantly different in both side of labial height and left side of heminasal width. Statistically significant differences were found on both side of transverse lip length and right side of heminasal width. Although the half of preoperative measurements were significantly different, trends of results showed average results were comparable.Conclusion: This is the first study in Korea to simultaneously compare digital 3D photogrammetry with traditional direct anthropometry in unilateral cleft lip patients. We desire this study could contribute the methodological choice of the many researchers for proper surgical planning in cleft lip reconstruction field.OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000004298/10SEQ:10PERF_CD:SNU2013-01EVAL_ITEM_CD:102USER_ID:0000004298ADJUST_YN:YEMP_ID:A072100DEPT_CD:852FILENAME:김석화-3d-nose-2013.pdfDEPT_NM:치의과학과SCOPUS_YN:NCONFIRM:
Identification of C16orf74 as a Marker of Progression in Primary Non-Muscle Invasive Bladder Cancer
PURPOSE: Methylation-induced silencing of PRSS3 has been shown to be significantly associated with invasive bladder cancer, and expression of the C16orf74 gene locus has been shown to correlate positively with PRSS3. The aim of the current study was to evaluate the relationship between C16orf74 expression level and progression in non-muscle invasive bladder cancer (NMIBC). MATERIALS AND METHODS: C16orf74 mRNA levels were examined by real-time reverse transcriptase polymerase chain reaction (RT-PCR) analysis of 193 tumor specimens from patients with primary NMIBC. Expression data were analyzed in terms of clinical and experimental parameters. Kaplan-Meier curves and multivariate Cox regression models, respectively, were used to determine progression-free survival and to identify independent predictive parameters of progression. RESULTS: Analysis using Kaplan-Meier curves revealed prolonged progression-free survival of high-C16orf74-expressors as compared to low-expressors (p<0.001). Multivariate Cox regression analysis revealed that low C16orf74 mRNA expression levels are a significant risk factor for disease progression in patients with primary NMIBC (HR: 10.042, CI:2.699-37.360, p = 0.001). CONCLUSIONS: Decreased expression of C16orf74 correlates significantly with progression in primary NMIBC. C16orf74 expression level represents a potentially useful marker for predicting progression in primary NMIBC patients
A Case of Inadvertent Anterior Chamber and Corneal Stromal Injection with Antibiotics during Cataract Operation
Purpose: To report a case of inadvertent anterior chamber and cornea stromal injection with high dose antibiotics and steroids during cataract operation.
Methods: During cataract operation on a 78 year-old female patient, high dose gentamicin (20 mg/0.5 ml) and dexamethasone (2 mg/0.5 ml) were inadvertently injected into the anterior chamber and cornea stroma when making cornea edema for sealing of the incision sites. Anterior chamber irrigation with balanced salt solution (BSS) was immediately administered. On postoperative day one, extensive cornea edema was noted, and best-corrected visual acuity was 0.2. Descemet's membrane folds were observed around the corneal incision sites. Topical 5% NaCl and 1% prednisolone were started.
Results: Four weeks postoperatively, corneal edema began to reduce significantly. At four months postoperatively, corneal edema fully resolved, and best-corrected visual acuity was 0.8. However, some Descemet's membrane folds still remained, and a decrease in the number of endothelial cells was noted by specular microscope.
Conclusions: In this case involving anterior chamber and cornea stromal injection with high dose antibiotics and steroids, immediate anterior chamber irrigation with balanced salt solution seemed an appropriate management, and the patient's long-term visual acuity appears good. To prevent such mistakes, precise labeling of all solutions and use of different syringe needles should be considered.ope
increased Igfbp2 Levels By Placenta-Derived Mesenchymal Stem Cells Enhance Glucose Metabolism in a Taa-injured Rat Model Via ampk Signaling Pathway
The insulin resistance caused by impaired glucose metabolism induces ovarian dysfunction due to the central importance of glucose as a source of energy. However, the research on glucose metabolism in the ovaries is still lacking. The objectives of this study were to analyze the effect of PD-MSCs on glucose metabolism through IGFBP2-AMPK signaling and to investigate the correlation between glucose metabolism and ovarian function. Thioacetamide (TAA) was used to construct a rat injury model. PD-MSCs were transplanted into the tail vein (2 × 1
A Phase II Study of Modified FOLFOX4 for Colorectal Cancer Patients with Peritoneal Carcinomatosis
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