Dialectics of Efficient Change Management in the Regional Social Systems

The research has placed emphasis on the role of the social infrastructure sectors, providing social services, which facilitate human potential development in a modern state. Theoretical positions of the scientist considering the nature of social benefits and necessity of the government support for the social sphere has been summarized in the article. The state of the Russian social infrastructure sectors has been considered and the analysis of their performance compared to these of the social infrastructure sectors in other countries has been conducted in the research work. Taking into consideration the performance ratings of the effectiveness of the national education systems, the countries around the world concerning the effectiveness of the health system, the countries around the world concerning the social development level in 2014, the authors have proposed the conceptual approach that makes it possible to consider the correlation and interrelation of the level of the government financing of the social sphere and the dynamics of the contribution of social infrastructure sectors in the development of the human capital, ensuring the gross domestic product increase. The necessity of making innovative changes in the socio-economic systems of the social infrastructure sectors, to improve their performance, taking into account the results obtained, in the first place, in health care, has been wellgrounded and theoretical approaches to the changes management in the socio-economic systems has been studied in the article. The theoretical approaches to the changes management in the socio-economic systems have been studied by the authors. Based on the conducted studies and the formed theoretical basis for improving the level of changes management in open socio-economic systems, for the purpose of development of the theoretical and methodological approaches to changes management as applied to health care sphere, optimization model of management of health care organizations by way of ranking of manageable and unmanageable changes has been proposed. The possibility of using management optimization by way of ranking of manageable and unmanageable changes in the health care management at different levels has been confirmed with high-performance indicators at the micro-, meso- and macro levels in the sector, by the example of implementation of the national project “Health” and innovative organizational changes facilitating the return to work of patients of the working age, which are involved in the gross domestic product formation in the city of Yekaterinburg.The article has been prepared with the support of the Russian Science Foundation grant No. 14-18-00456 “Support of geoecosocioeconomic approach to development of strategic nature resources capacity of the low-studied northern territories within the investment project “Arctic — Central Asia”

Rare events – rare attractors; formalization and examples

Analogy between attractors in nonlinear dynamics, called “rare attractors” by M.V. Zakrzhevsky and his colleagues [1] and emergencies, such as natural and technogenic catastrophes as well as downfalls caused by risky economic policies and strategies has been discussed. Examples of rare but technically significant attractors in nonlinear dynamics have been give

On the equations of the analytical dynamics of the quasi-3D plate theory of I. N. Vekua type and some their solutions

The plate theory of Nth order is constructed on the background of the Lagrangian variational formalism of analytical dynamics of continuum systems and the dimensional reduction approach of I. N. Vekua – A. A. Amosov. The plate model is defined within the configuration space, the set of field variables, and the Lagrangian density. The field variables are determined by the coefficients of the biorthogonal expansion of the spatial displacement vector field with respect to the dimensionless normal coordinate. The dynamic equations are derived as Lagrange equations of the second kind of the two-dimensional continuum system. The dynamics of the plane elastic layer is considered as an example, the normal wave propagation is described on the basis of refined plate theories of various orders, and the convergence of approximate solutions to the exact solution of the three-dimensional elastodynamics problem is analyzed for different wavenumbers

Long-distance entanglement and quantum teleportation in XX spin chains

Isotropic XX models of one-dimensional spin-1/2 chains are investigated with the aim to elucidate the formal structure and the physical properties that allow these systems to act as channels for long-distance, high-fidelity quantum teleportation. We introduce two types of models: I) open, dimerized XX chains, and II) open XX chains with small end bonds. For both models we obtain the exact expressions for the end-to-end correlations and the scaling of the energy gap with the length of the chain. We determine the end-to-end concurrence and show that model I) supports true long-distance entanglement at zero temperature, while model II) supports {\it ``quasi long-distance''} entanglement that slowly falls off with the size of the chain. Due to the different scalings of the gaps, respectively exponential for model I) and algebraic in model II), we demonstrate that the latter allows for efficient qubit teleportation with high fidelity in sufficiently long chains even at moderately low temperatures.Comment: 9 pages, 6 figure

Rare events – rare attractors; formalization and examples

Analogy between attractors in nonlinear dynamics, called “rare attractors” by M.V. Zakrzhevsky and his colleagues [1] and emergencies, such as natural and technogenic catastrophes as well as downfalls caused by risky economic policies and strategies has been discussed. Examples of rare but technically significant attractors in nonlinear dynamics have been give

Pairing state in multicomponent superconductors

We use the microscopic weak coupling theory to predict the pairing state in superconductors of cubic, hexagonal, or tetragonal symmetry, where the order parameter is multicomponent, i.e., transforms according to either a 2-dimensional or a 3-dimensional representation of the crystal point group. We show that the superconducting phase usually breaks the time-reversal symmetry for singlet multicomponent superconductors. The superconducting order parameter for triplet superconductors in most cases turns out to be non-magnetic.Comment: 7 page

Phagocytosis and oxidative activity of neutrophils after interaction with uropathogenic <i>Escherichia coli</i> biofilms

Recurrent urinary tract infections (UTIs) are associated primarily with the ability of Escherichia coli to form biofilms. The interaction of neutrophils, factors of innate immunity, with microorganisms in biofilms is difficult compared to planktonic forms due to the lack of direct contact, as well as due to the antiphagocytic action of the extracellular matrix of biofilms. The purpose of this study was evaluation of neutrophils phagocytic and oxidative activity during interaction with biofilms of uropathogenic E. coli (UPEC) DL82 and R44. Peripheral blood neutrophils from healthy men were isolated using ficoll-urographin double gradient, incubated for 1 h with bacterial cells from biofilms or their supernatants, then leukocytes functional activity was evaluated. Phagocytic activity of neutrophils was determined by the degree of bioluminescence inhibition of bioluminescent strain E. coli K12 TG1 lux+ (pXen) upon their absorption by neutrophils. Production of extracellular reactive oxygen species (ROS) was analyzed by the intensity of luminol-dependent chemiluminescence in spontaneous and stimulated by E. coli K12 variants. Significance of differences was determined using Student’s t-test at p &lt; 0.05. It was found that neutrophils interaction with UPEC biofilm cells or supernatants did not affect the phagocytic activity. E. coli DL82 supernatants reduce neutrophils spontaneous ROS production compared to control and biofilm cells. E. coli R44 supernatants with a low virulence potential did not affect ROS production, while biofilm cells stimulated it. When assessing stimulated ROS production, exposure to R44 strain supernatants did not cause a decrease in neutrophils activation in response to an external stimulus (E. coli K12 cells). Preliminary contact of neutrophils with E. coli R44 bacteria resulted in a high and prolonged level of ROS production compared to the control. Neutrophils interaction with DL82 cells resulted in a higher level of ROS compared to supernatants, however a subsequent rapid depletion of neutrophils oxidative potential was observed. Thus, cells and supernatants of UPEC biofilms can determine the activation of neutrophils