Corrosion and Mechanical Properties of Austenic Steel Weld Joints

This paper presents results of experiments on how tungsten, molybdenum and aluminum oxyhydroxide nanopowders, imbedded into the weld pool, affect corrosion resistance and mechanical properties of welded joints. It is shown that nanopowders have a significant effect on the intergranular corrosion of the weld

Grothendieck ring of varieties, D- and L-equivalence, and families of quadrics

We discuss a conjecture saying that derived equivalence of smooth projective simply connected varieties implies that the difference of their classes in the Grothendieck ring of varieties is annihilated by a power of the affine line class. We support the conjecture with a number of known examples, and one new example. We consider a smooth complete intersection X of three quadrics in P5 and the corresponding double cover Y→P2 branched over a sextic curve. We show that as soon as the natural Brauer class on Y vanishes, so that X and Y are derived equivalent, the difference [X]−[Y] is annihilated by the affine line class

The Fabrication of Bioresorbable Implants for Bone Defects Replacement Using Computer Tomogram and 3D Printing

The present work demonstrates the possibility of production of personalized implants from bioresorbable polymers designed for replacement of bone defects. The stages of creating a personalized implant are described, which include the obtaining of 3D model from a computer tomogram, development of the model with respect to shape of bone fitment bore using Autodesk Meshmixer software, and 3D printing process from bioresorbable polymers. The results of bioresorbable polymer scaffolds implantation in pre-clinical tests on laboratory animals are shown. The biological properties of new bioresorbable polymers based on poly(lactic acid) were studied during their subcutaneous, intramuscular, bone and intraosseous implantation in laboratory animals. In all cases, there was a lack of a fibrous capsule formation around the bioresorbable polymer over time. Also, during the performed study, conclusions were made on osteogenesis intensity depending on the initial state of bone tissue

The Fabrication of Bioresorbable Implants for Bone Defects Replacement Using Computer Tomogram and 3D Printing

The present work demonstrates the possibility of production of personalized implants from bioresorbable polymers designed for replacement of bone defects. The stages of creating a personalized implant are described, which include the obtaining of 3D model from a computer tomogram, development of the model with respect to shape of bone fitment bore using Autodesk Meshmixer software, and 3D printing process from bioresorbable polymers. The results of bioresorbable polymer scaffolds implantation in pre-clinical tests on laboratory animals are shown. The biological properties of new bioresorbable polymers based on poly(lactic acid) were studied during their subcutaneous, intramuscular, bone and intraosseous implantation in laboratory animals. In all cases, there was a lack of a fibrous capsule formation around the bioresorbable polymer over time. Also, during the performed study, conclusions were made on osteogenesis intensity depending on the initial state of bone tissue

Response to : The GPRC5A frameshift variant c.183del is not associated with increased breast cancer risk in BRCA1 mutation carriers

Non peer reviewe

Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers

Ovarian carcinomas (OC) often demonstrate rapid tumor shrinkage upon neoadjuvant chemotherapy (NACT). However, complete pathologic responses are very rare and the mechanisms underlying the emergence of residual tumor disease remain elusive. We hypothesized that the change of somatic BRCA1 status may contribute to this process. The loss-of-heterozygosity (LOH) at the BRCA1 locus was determined for 23 paired tumor samples obtained from BRCA1 germ-line mutation carriers before and after NACT. We observed a somatic loss of the wild-type BRCAI allele in 74% (17/23) of OCs before NACT. However, a retention of the wild-type BRCA1 copy resulting in a reversion of LOH status was detected in 65% (11/17) of those patients after NACT. Furthermore, we tested 3 of these reversion samples for LOH at intragenic BRCA1single nucleotide polymorphisms (SNPs) and confirmed a complete restoration of the SNP heterozygosity in all instances. The neoadjuvant chemotherapy for BRCA1-associated OC is accompanied by a rapid expansion of pre-existing BRCA1-proficient tumor clones suggesting that continuation of the same therapy after NACT and surgery may not be justified even in patients initially experiencing a rapid tumor regression. (C) 2017 Elsevier B.V. All rights reserved.Peer reviewe

An Advanced Neutron Spectrometer for Future Manned Exploration Missions

An Advanced Neutron Spectrometer (ANS) is being developed to support future manned exploration missions. This new instrument uses a refined gate and capture technique that significantly improves the identification of neutrons in mixed radiation fields found in spacecraft, habitats and on planetary surfaces. The new instrument is a composite scintillator comprised of PVT loaded with litium-6 glass scintillators. We will describe the detection concept and show preliminary results from laboratory tests and exposures at particle accelerator

In-plane Switching Deformed Helix Ferroelectric Liquid Crystal Display Cells

In-plane electro-optical switching (IPS) is a natural feature of a conventional planar-aligned display cell based on the deformed helix ferroelectric liquid crystal effect (DHFLC-effect) with a sub-wavelength helix pitch, if the tilt angle is close to 40 degrees

Extraction of Brown Coals from Kansk-Achinsk and Lena Basins with Toluene and Water Containing Fluids

The conversion of different brown coals from the Kansk-Achinsk and Lena Basins in an aqueous medium and in toluene containing mixtures with water and tetralin additives was studied under supercritical conditions over the temperature range of 375-550 °C and at pressures from 7 to 40 MPa. It was found that the liquefaction of brown coals in the medium of toluene solvent with small amount of hydrogen-donor tetralin co-solvent effectively occurred at low temperature 400 °C. On the other hand, coal methanation, hydrolysis, and oxidation reactions with the predominant generation of methane, carbon dioxide, and hydrogen prevailed in the water containing mediums. In a supercritical toluene at 440 °C, the addition of a small amount of water (15 %) stimulated destruction of coals with the predominant production of liquid products and moderate gas yields. The use of calcium oxide, sodium hydroxide and hematite as the catalysts increased the yields of liquid products.Изучено превращение бурых углей Канско-Ачинского и Ленского бассейнов в водной среде и в смеси толуола с водой и тетралином при сверхкритических параметрах в температурном интервале 375-550°С и давлении от 7 до 40 MPa. Установлено, что в среде толуола с добавкой небольшого количества сорастворителя тетралина ожижение бурых углей эффективно происходит при низкой температуре 4000 °C. В водной среде проходят реакции метанирования, гидролиза и окисления бурых углей с образованием в основном газообразных продуктов (метана, диоксида углерода и водорода).В среде толуола в сверхкритических условиях при 400°С добавление небольшого количества воды (15 %) стимулирует процесс деструкции углей с образованием преимущественно жидких продуктов при умеренном газообразовании. Применение в качестве катализаторов оксида кальция, гидроксида натрия и гематита позволяет увеличить выход жидких продуктов