39 research outputs found
Changes in circulating microRNA levels associated with prostate cancer
BACKGROUND: The aim of this study was to investigate the hypothesis that changes in circulating microRNAs (miRs) represent
potentially useful biomarkers for the diagnosis, staging and prediction of outcome in prostate cancer.
METHODS: Real-time polymerase chain reaction analysis of 742 miRs was performed using plasma-derived circulating microvesicles
of 78 prostate cancer patients and 28 normal control individuals to identify differentially quantified miRs.
RESULTS: A total of 12 miRs were differentially quantified in prostate cancer patients compared with controls, including 9 in patients
without metastases. In all, 11 miRs were present in significantly greater amounts in prostate cancer patients with metastases
compared with those without metastases. The association of miR-141 and miR-375 with metastatic prostate cancer was confirmed
using serum-derived exosomes and microvesicles in a separate cohort of patients with recurrent or non-recurrent disease following
radical prostatectomy. An analysis of five selected miRs in urine samples found that miR-107 and miR-574-3p were quantified at
significantly higher concentrations in the urine of men with prostate cancer compared with controls.
CONCLUSION: These observations suggest that changes in miR concentration in prostate cancer patients may be identified by analysing
various body fluids. Moreover, circulating miRs may be used to diagnose and stage prostate cance
A pilot study of tumor-derived exosomes as diagnostic and prognostic markers in breast cancer patients receiving neoadjuvant chemotherapy.
Analysis of blood-derived circulating microvesicles for microRNA biomarkers of metastatic and nonmetastatic prostate cancer.
Evaluation of the Probability of Spinal Damage Caused by Sustained Cyclic Compression Loading
Biomechanical comparison of supplemental posterior fixations for two-level anterior lumbar interbody fusion
Consortium for Osteogenesis Imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans
Osteogenesis imperfecta (OI) is a generalized disorder of connective tissue characterized by fragile bones andeasy susceptibility to fracture. Most cases of OI are caused by mutations in type I collagen. We have identifiedand assembled structural mutations in type I collagen genes (COL1A1 and COL1A2, encoding the proa1(I)and proa2(I) chains, respectively) that result in OI