Exponential corrections to low-temperature expansion of 2D non-abelian models

The thermodynamic limit of certain exponential corrections to the weak coupling expansion of two-dimensional models is investigated. The expectation values of operators contributing to the first order coefficient of the low-temperature expansion of the free energy are calculated for the order O(e^{-\beta}). They are proven to diverge logarithmically with the volume for non-abelian models.Comment: 9 page

Comparative assessment of various methods of studying the skin toxicity of a wound-healing drug

The article presents the results of studying the subacute skin toxicity of a wound-healing cream based on betamethasone dipropionate, gentamicin sulfate, and clotrimazole. According to the Organization for Economic Cooperation and Development (OECD No. 410), the research was conducted using the classic method. When studying the effect of a wound-healing agent on the body of animals during long-term 28-day dermal application by the classical method in animals of the I, II, and III experimental groups, which received the drug in a dose of 0.5, 2.5, and 5 ml/kg body weight; respectively no significant changes were found in the body weight of the animals and the weight coefficients of the liver, heart, spleen, kidneys, and lungs. At the same time, in the animals of the II and III research groups, a slight increase in the concentration of hemoglobin was noted, respectively, by 1.3 and 3.9 %, the level of urea – 5.3 and 11.2 %, the activity of AST – 9.8 and 14.9 % compared to the indicators of animals of the control group. In these groups, there was a decrease in total protein concentration by 5.5 and 6.8 %, creatinine level by 3.1 and 5.3 %, and ALT activity by 6.5 and 9.7 %. The studies conducted according to the OECD No. 410 make it possible to obtain more informative data on the toxic effect of the investigated agent. In particular, it was established that the use of the researched drug in animals of the I, II, and III experimental groups caused a decrease in the weight coefficients of the spleen mass, respectively, by 19.1 (Р < 0.05), 22.4 (Р < 0.05) and 28.3 % (P < 0.05), hearts – 3.6, 4.6 and 7.7 %, kidneys – 4.9, 6.5 and 10.4 % and animal body weight – 4.5, 5.4 and 6.4 %, hemoglobin concentrations – 2.6, 2.9 and 4.4 %, leukocyte counts – 21.4, 16.1 and 15.1 %, hematocrit values – 1.9, 3, 6 and 4.0 %. The average hemoglobin content in the erythrocyte (MSN) also decreased by 8.3, 6.9, and 5.1 %, and the average erythrocyte (MCV) volume was 5.0, 4.7, and 1.7 %. In addition, an increase in weight coefficients of liver mass was established by 10.8 (P < 0.05), 11.8 (P < 0.05), and 15.6 % (P < 0.05). When studying the effect of the researched agent during 28-day dermal application on biochemical indicators of blood serum in animals of the first experimental group, a decrease in the concentration of total protein by 5.8 % was established. Under these conditions, an increase in creatinine level, urea level, ALT, and AST was established, respectively, by 6.2, 18.8 (P < 0.05), 3.8, and 14.7 % (P < 0.05). It should be noted that the use of the researched product in animals of the II and III experimental groups caused an increase in the level of urea, respectively, by 28.6 and 35.7 % (Р < 0.05), creatinine by 8.4 and 3.5 %, AST – 16.4 (P < 0.05) and 11.3 % and the activity of ALT – 8.5 and 11.0 %

Light-scattering properties of microorganisms Desulfuromonas acetoxidans by influence of silver

The article deals with the concentration changes and relative content of bacterial cells of Desulfuromonas acetoxidans in the intervals of sizes 0.2–2.0 µm under the influence of nano silver particles. Correlation between these changes of light-scattering properties of bacterial cells and growth abilities of bacteria Desulfuromonas acetoxidans under inflence of silver nanoparticles and ions has been shown. The purpose of the work was to research the intensity of processes the change of indexes of the antioxidant system the cells of Desulfuromonas acetoxidans at influence of silver nanoparticles and silver nitrate. The influence of various concentrations of silver nanoparticles and silver nitrate on enzymatic activity of catalase and reduced glutathione synthesis by Desulfuromonas аcetoxidans cells under their cultivation with fumarate addition and with absence of sulphur has been determined. Specific catalase activity increased with enhancing of concentration and duration of bacterial cultivation under the addition of this salt. The highest specific catalase activity was determined on the second day of bacterial growth under the influence of all concentration range of investigated metal salt. The reduced glutathione content under silver nitrate and silver nanoparticles exposure varied depending on the cultivation time and metal concentration. The maximum reduced glutathione content has been observed. The result of catalase activity changes  and glutathione content changes of sulfur-reducing D. acetoxidans bacteria cell-free extracts and has been investigated under the influence of different concentrations of Ag nanoparticles during four days of cultivation has been investigated

DETERMINATION OF CONTENT VITAMIN B IN BIOACTIVE PRODUCTS BASED ON PEPTIDOGLYCAN BY CAPILLARY ELECTROPHORESIS

У статті наведено результати досліджень щодо визначеня вмісту водорозчинних вітамінів групи В у біологічно активному засобі на основі пептидоглікану кисломолочних бактерій та пробіотику «Пробіл» методом капілярного електрофорезу на приладі Капель-105/105М. За результатами досліджень складових компонентів біологічно активного засобу встановлено, що до його складу входить ряд водорозчинних вітамінів групи В, зокрема В1, В2, В6, В5, В3 та Вс. При вивченні в порівняльному аспекті вмісту вітамінів групи В встановили, що у біологічно активному засобі концентрація вітамінів В1, В2, В6, В5 була відповідно у 6,6, 5,7, 1,7 та 1,6 раза вищою, ніж у пробіотику «Пробіол», що вказувало на високу біологічну активність досліджуваного препарату.The article presents the result of the study of water-soluble B vitamins in biologically active product containing peptidoglycans  dairy bacteria and probiotic «Probiol» by capillary electrophoresis using equipment Capel-105/105M. According to the research components of biologically active product found that it consist of water-soluble vitamins, including В1, В2, В6, В5, В3 and Вс. It was found that concentration В1, В2, В6, В5, В3 and Вс in biologically active product were respectively  in 6,6, 5,7, 1,7 and 1,6 times higher than in probiotic «Probiol», thats indicated on a high biological activity of drug

The influence of xylate on the volumo- and osmoregulatory function of the kidneys in diabetes complicated by the syndrome of endogenous intoxication of purulent-septic origin.

The combination of insulin-independent diabetes mellitus with endogenous purulent-septic genesis syndrome is a fairly common nosology. The search for ways to optimize the results of its treatment, after screening observations, led to the expediency to consider the pharmacodynamic aspects of the action of polyhydric alcohols through the prism of homeostatic support functions. Detailing this direction was focused on the consideration of the action of xylate mediated through the volumetric and osmoregulatory function of the kidneys. The effect of xylate on the volumo-and osmoregulatory function of the kidneys in insulin-independent diabetes mellitus complicated by the syndrome of endogenous intoxication of purulent-septic origin was investigated. The study group consisted of 53 patients with insulin-independent diabetes mellitus complicated by the syndrome of endogenous intoxication of purulent-septic origin (IDCSEI). Under the condition of infusion loading (3 ml/kg/h for three hours) with Ringer's solution or xylate within the fragments of planned intensive care, indicators characterizing the state of the volumo- and osmoregulatory function of the kidneys were investigated. The loading with Ringer's solution in patients with IDCSEI increases sodium clearance by 260±47.8% (Δ, p=0.020), without changing the concentration of sodium ions in the blood plasma and filtration fraction and purifying the blood plasma from osmotically active substances 147±46.9% ( Δ, p=0.011). Extension of the extracellular space by infusion solutions by 3 ml/kg/h for three hours in patients with insulin-dependent diabetes mellitus, complicated by the syndrome of endogenous intoxication by purulent-septic genesis, activates volumetric and osmoregulatory function. Extension of extracellular space with infusion solu­tion by 3 ml/kg/h for three hours in patients with insulin-independent diabetes mellitus activates volumo- and osmo­regulatory function. Activation of volumetric function occurs by reducing the reabsorption of sodium and water in the proximal nephron, without increase of glomerular filtration rate, increasing the distal transport of sodium and water

The role of students’ individual work in the formation of professional competences of future doctors.

Modern requirements for training of high-skilled specialists require the implementation of international medical and educational standards in the educational and integrative process. Formation of cognitive activity, pursuance of professional development, the necessity to correspond to world standards medical students’ of gained knowledge. Medical students’ individual work is very important for medical students’ education because it helps to systematize and use knowledge that was gained in practical classes. The aim of the work – to analyze the forms of students’ individual work, used at in the Department of Internal Medicine 2 and Phthisiology, in order to improve the educational process and to form the future doctor’s medical judgment, their ability to self-improvement and self-education. The recommended hours attempted for students’ individual work is 90 out of the total of 240 hours assigned to the discipline in teaching the module “internal diseases” for the 5th year students at the Depertment of Internal Medicine 2 and Phthisiology. In studying the discipline of "internal diseases" in the 5th year one of the main tasks of medical student’s occupation training is mastering ability of assimilation on his own, of knowledge and refresh it, and then to use knowledge effectively in the future career. The difference of the individual work lies in the fact that students can study individually choosing the necessary kind of extracurricular activity according to their interests. In addition, the lack of strict grading by the teacher has more advantages compared to practical classes. The curriculum, the teacher’s tasks and methodological materials determine the content of the individual work. The article presents the three main directions of students’ individual work in teaching discipline of "internal diseases" for students of the 5th year as: students’ individual work in classroom learning, students’ individual work individual work under the teacher’s supervision. When discussing the results of individual work, students learn to think critically, communicate with each other, and make their own well-thought-out (educated) decision. Well-structured process of the individual work encourages medical students to its qualitative fulfillment and it is a significant motivation for further professional growth. Significant reserves to increase its efficiency inherent in the use of modern computer technology. Medical students’ individual work should be considered as one of the necessary stages of a modern doctor training. The latest information technologies and individual scientific projects adoption into the educational process leads to efficiency improvement and it forms new future doctor’s professional competences