PND61 Cost-Utility of Fingolimod Compared With Dimethyl Fumarate (Dmf) In Highly Active Relapsing Remitting Multiple Sclerosis (Rrms) In England: Comparison of A Markov and Discrete Event Simulation Model

Numeración errónea en el original

2014 Crop Performance in Southeast Kansas

Crop variety testing determines the production potential of newly released crop cultivars in Southeast Kansas. The genetic potential is moderated by environmental conditions during the growing season as well as soil productive capacity

<i>Schistosoma mansoni</i> cercariae experience influx of macromolecules during skin penetration

We have observed that when cercariae penetrate the skin of mice, there is influx into their tissues of Lucifer Yellow and certain labelled molecules of up to 20 kDa molecular weight. This observation was made using a variety of fluorescent membrane-impermeant compounds injected into the skin before the application of cercariae. This unexpected phenomenon was investigated further by transforming cercariae in vitro in the presence of the membrane-impermeant compounds and examining the distribution by microscopy. In schistosomula derived from this procedure, the nephridiopore and surface membrane were labelled while the pre- and post-acetabular glands were not labelled. The region associated with the oesophagus within the pharyngeal muscle clearly contained the fluorescent molecules, as did the region adjacent to the excretory tubules and the germinal mass. We used cercariae stained with carmine to aid identification of regions labelled with Lucifer Yellow. Although the mechanism of this influx is unclear, the observation is significant. From it, we can suggest an hypothesis that, during skin penetration, exposure of internal tissues of the parasite to external macromolecules represents a novel host-parasite interfac

Soft sensor design for the optimisation of parallel debutaniser columns: an industrial case study

This work demonstrates a practical implementation of a soft sensor to estimate the C5 hydrocarbon impurity in the butane product of a liquid petroleum gas (LPG) recovery system. Such a sensor can then subsequently be used to optimise the process. The process has two parallel debutaniser columns that feed a common LPG recovery system. The optimisation objective is to minimise the Reid vapour pressure (RVP) of the two debutaniser bottoms’ products. This optimisation problem can be solved with a simple advanced control implementation. However, the ability of the controller to minimise the process variation and drive the process to the optimal point is directly influenced by the quality of the constraining process variable. In this case, the key controlled variable (CV) is the debutaniser overheads C5 mass fraction. The designed soft sensor for this CV uses the general distillation shortcut (GDS) method, and is shown to represent the distillation column operation well. This work presents a derivation of the GDS method, and formulates a new approach for the feedback biasing of the two parallel debutaniser soft sensors.https://www.journals.elsevier.com/ifac-papersonlinepm2021Electrical, Electronic and Computer Engineerin

Effects of irradiation and tunicamycin on the surface glycoproteins Schistosoma mansoni

The cercarial glycocalyx and schistosomulum surface contains a number of glycoproteins which are expressed in very variable amounts within a parasite population. Tunicamycin inhibits glycoprotein synthesis of schistosomula if the parasites are incubated for 24hr with the drug (10µg ml[raised to the power of -1]). An unexpected increase in lectin binding to the parasite surface was observed but no other changes were detected. Schistosomula treated in this way did not develop in the host past the lung stage. Ultraviolet irradiation (400µW min cm[raised to the power of-2]) also inhibited glycoprotein synthesis. Synthesis of other proteins, and in particular heat shock proteins, were also inhibited. Sera from mice (NIH strain) infected with irradiated cercariae contained antibodies which bound to normal schistosomula with lower affinity than to irradiated parasites. This is evidence that irradiation modifies the surface and secreted glycoproteins of schistosomula, so they are processed in a different way to normal glycoproteins by the host's immune system. The effects of irradiation on heat shock protein synthesis may allow the parasite to release a variety of proteins and glycoproteins in abnormal conformations. This may explain the enhanced immunogenicity of irradiated cercariae

The economic burden of alcohol dependence in europe.

AIMS: To determine the economic burden pertaining to alcohol dependence in Europe. METHODS: Database searching was combined with grey literature searching to identify costs and resource use in Europe relating to alcohol dependence as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) or the World Health Organisation's International Classification of Diseases (ICD-10). Searches combined MeSH headings for both economic terms and terms pertaining to alcohol dependence. Relevant outcomes included direct healthcare costs and indirect societal costs. Main resource use outcomes included hospitalization and drug costs. RESULTS: Compared with the number of studies of the burden of alcohol use disorders in general, relatively few focussed specifically on alcohol dependence. Twenty-two studies of variable quality were eligible for inclusion. The direct costs of alcohol dependence in Europe were substantial, the treatment costs for a single alcohol-dependent patient lying within the range euro1591-euro7702 per hospitalization and the annual total direct costs accounting for 0.04-0.31% of an individual country's gross domestic product (GDP). These costs were driven primarily by hospitalization; in contrast, the annual drug costs for alcohol dependence were low. The indirect costs were more substantial than the direct costs, accounting for up to 0.64% of GDP per country annually. Alcohol dependence may be more costly in terms of health costs per patient than alcohol abuse. CONCLUSIONS: This review confirms that alcohol dependence represents a significant burden for European healthcare systems and society. Difficulties in comparing across cost-of-illness studies in this disease area, however, prevent specific estimation of the economic burden

Taming the Shrew -Resolving Structural Heterogeneities with Hierarchical CPNs *

Abstract. Model transformations play a key role in the vision of ModelDriven Engineering (MDE) whereby the overcoming of structural heterogeneities, being a result of applying different meta-modeling constructs for the same semantic concept, is a challenging, recurring problem, urgently demanding for reuse of transformations. In this respect, an approach is required which (i) abstracts from the concrete execution language allowing to focus on the resolution of structural heterogeneities, (ii) keeps the impedance mismatch between specification and execution low enabling seamless debuggability, and (iii) provides formal underpinnings enabling model checking. Therefore, we propose to specify model transformations by applying a set of abstract mapping operators (MOPs), each resolving a certain kind of structural heterogeneity. For specifying the operational semantics of the MOPs, we propose to use Transformation Nets (TNs), a DSL on top of Colored Petri Nets (CPNs), since it allows (i) to keep the impedance mismatch between specification and execution low and (ii) to analyze model transformations by evaluating behavioral properties of CPNs