イリジウム触媒を用いたアリールエーテルの炭素-炭素結合形成を伴う骨格変換反応の開発

京都大学新制・課程博士博士(工学)甲第24148号工博第5035号新制||工||1786(附属図書館)京都大学大学院工学研究科合成・生物化学専攻(主査)教授 杉野目 道紀, 教授 大江 浩一, 教授 中尾 佳亮学位規則第4条第1項該当Doctor of Philosophy (Engineering)Kyoto UniversityDGA

数学カリキュラム開発の社会文化的側面に関する研究 : モザンビーク国家カリキュラムを事例として

広島大学(Hiroshima University)博士(教育学)Doctor of Philosophy in Educationdoctora

Exploring the Endogenous Development of Mathematics Curriculum in the African Context from the Perspective of Educational Borrowing Theory

Appropriate curriculum revision is an urgent issue for every African country to achieve. It is crucial to implement revisions by using the accumulated knowledge and experience in each country. This study firstly develops an analytical framework using educational borrowing theory for exploring the level and form of endogeneity in mathematics curriculum development. Secondly, using developed framework, characteristics of mathematics curriculum development in African countries are analysed based on the literature review from colonial period to recent years. As a result, the author found that African countries are steadily revising their mathematics curriculum, with regard to the domestic educational situation. However, in recent years, many African countries are pursuing curriculum revisions in accordance with the educational policies framed by international institutions because of the globalisation of education. In addition, the analytical framework proposed in this study can be used to analyse the endogeneity in curriculum development, and proceed with appropriate curriculum developmen

An enhancer peptide for membrane-disrupting antimicrobial peptides

<p>Abstract</p> <p>Background</p> <p>NP4P is a synthetic peptide derived from a natural, non-antimicrobial peptide fragment (pro-region of nematode cecropin P4) by substitution of all acidic amino acid residues with amides (i.e., Glu → Gln, and Asp → Asn).</p> <p>Results</p> <p>In the presence of NP4P, some membrane-disrupting antimicrobial peptides (ASABF-α, polymyxin B, and nisin) killed microbes at lower concentration (e.g., 10 times lower minimum bactericidal concentration for ASABF-α against <it>Staphylococcus aureus</it>), whereas NP4P itself was not bactericidal and did not interfere with bacterial growth at ≤ 300 μg/mL. In contrast, the activities of antimicrobial agents with a distinct mode of action (indolicidin, ampicillin, kanamycin, and enrofloxacin) were unaffected. Although the membrane-disrupting activity of NP4P was slight or undetectable, ASABF-α permeabilized <it>S. aureus </it>membranes with enhanced efficacy in the presence of NP4P.</p> <p>Conclusions</p> <p>NP4P selectively enhanced the bactericidal activities of membrane-disrupting antimicrobial peptides by increasing the efficacy of membrane disruption against the cytoplasmic membrane.</p

超音速ジェットレーザー分光によるジベンゾ-18-クラウン-6-エーテルのゲスト分子認識機構の解明

第4回分子科学討論会, 2010年9月14日-17日, 大阪大学豊中キャンパス(大阪), 3A0

Review of Competences in Primary Education Curriculum in Mozambiqu : How an Assessment is Supposed to Be Done on It in Mathematics?

This article aims to discuss competence assessment in primary education in Mozambique, based in the New Curriculum perspective (INDE, 2020), the transformations in the assessment regulation (MINEDH, 2019), and our experience as a teacher and pedagogical technician in Mozambique. The article consists in review of official documents, Primary Education Curricula and mathematic curriculum. The Mozambican assessment regulation previews different types of assessment, however, the summative assessment, highlighting grading, tends to be the most common practice, ignoring the development of competences that implies a competence assessment. We suggest a deep reflection to adjust the prescribed practices to the reality of primary education in Mozambique

Environmentally Benign Ritter Reaction Using Bismuth Salts as a Catalyst

We developed an environmentally benign Ritter reaction of alcohols with nitriles using a commercially available bismuth salt as a less harmful catalyst. The detailed reaction profiles revealed that consumption of the ether by-product as the reaction proceeded was the key for optimizing this reaction, and the yield of the target amide was improved by adding a small amount of water. This finding clearly reveals the significance of using a bismuth salt as the catalyst, as it is not deactivated in the presence of water. This catalyst system has a broad substrate scope, and even with 1 mol% of the catalyst, the reaction progresses smoothly. It is also possible to react stoichiometric amounts of nitriles and alcohols, thus reducing the amount of organic solvent required for the reaction. Furthermore, as the inexpensive bismuth catalyst can be easily removed using aqueous hydrochloric acid, a purification process that only required washing and drying without any organic solvents was successfully established