Study of onboard expert systems to augment space shuttle and space station autonomy

The feasibility of onboard crew activity planning was examined. The use of expert systems technology to aid crewmembers in locating stowed equipment was also investigated. The crew activity planning problem, along with a summary of past and current research efforts, was discussed in detail. The requirements and specifications used to develop the crew activity planning system was also defined. The guidelines used to create, develop, and operate the MFIVE Crew Scheduler and Logistics Clerk were discussed. Also discussed is the mathematical algorithm, used by the MFIVE Scheduler, which was developed to aid in optimal crew activity planning

Space Applications of Automation, Robotics and Machine Intelligence Systems (ARAMIS), phase 2. Volume 1: Telepresence technology base development

The field of telepresence is defined, and overviews of those capabilities that are now available, and those that will be required to support a NASA telepresence effort are provided. Investigation of NASA's plans and goals with regard to telepresence, extensive literature search for materials relating to relevant technologies, a description of these technologies and their state of the art, and projections for advances in these technologies over the next decade are included. Several space projects are examined in detail to determine what capabilities are required of a telepresence system in order to accomplish various tasks, such as servicing and assembly. The key operational and technological areas are identified, conclusions and recommendations are made for further research, and an example developmental program is presented, leading to an operational telepresence servicer

Space applications of Automation, Robotics And Machine Intelligence Systems (ARAMIS). Volume 3, phase 2: Executive summary

The field of telepresence is defined, and overviews of those capabilities that are now available, and those that will be required to support a NASA telepresence effort are provided. Investigation of NASA's plans and goals with regard to telepresence, extensive literature search for materials relating to relevant technologies, a description of these technologies and their state of the art, and projections for advances in these technologies are included. Several space projects are examined in detail to determine what capabilities are required of a telepresence system in order to accomplish various tasks, such as servicing and assembly. The key operational and technological areas are identified, conclusions and recommendations are made for further research, and an example developmental program leading to an operational telepresence servicer is presented

Space Applications of Automation, Robotics and Machine Intelligence Systems (ARAMIS), phase 2. Volume 2: Telepresence project applications

The field of telepresence is defined and overviews of those capabilities that are now available, and those that will be required to support a NASA telepresence effort are provided. Investigation of NASA' plans and goals with regard to telepresence, extensive literature search for materials relating to relevant technologies, a description of these technologies and their state of the art, and projections for advances in these technologies over the next decade are included

Development and Field Evaluation of an Aquifer Stratification Testing System

An aquifer stratification testing system was designed, constructed, and tested. The system was designed to characterize vertical profiles of both quantity and quality of water produced from actively pumping groundwater wells. During testing, all systems functioned properly and either met or exceeded anticipated performance requirements. The system was first tested in an irrigation well completed in the Edwards aquifer and owned by the Onion Creek Club located in Manchaca, Texas, just south of Austin. The purpose of the exercise was to assess test systems performance and to develop and refine testing procedures. Dye-tracer injection tests were performed at five depths from 325 to 405 ft, and a velocity/discharge profile was generated for that interval. The profile was consistent with the karst nature of the Edwards aquifer. Water sampling procedures were tested and evaluated, but no samples were analyzed. Further testing was performed in two public water supply wells completed in the Ogallala Formation of the High Plains aquifer and belonging to the City of Wolfforth, Texas, to investigate arsenic and fluoride concentration distributions, which both exceed maximum contaminant level (MCL) standards for arsenic (10 μg/L) and fluoride (4 mg/L) in produced water. The results indicated vertical trends in both arsenic and fluoride aquifer concentration profiles, although concentrations at all depths exceeded MCL standards for both arsenic and fluoride. Despite distinctly different water discharge profiles between wells, a consistent inverse depth relationship between arsenic and fluoride concentrations was identified in both wells. Aquifer arsenic concentrations generally decreased, and aquifer fluoride concentrations generally increased with increasing depth. Aquifer arsenic concentrations ranged from 11.4 to 14.1 μg/L in Well 8 and from 16.0 to 22.2 μg/L in Well 5. Aquifer fluoride concentrations ranged from 5.53 to 7.98 mg/L in Well 8 and from 4.28 to 5.87 mg/L in Well 5. Future system and procedural modifications should focus on improving and enhancing the flexibility and data acquisition capabilities of the system. Future field testing programs should be performed to develop a water quality stratification database to enhance general understanding of groundwater quality and flow processes and provide insight on potential contamination sources.Bureau of Economic Geolog

Transistors

Contains reports on eight research projects.Lincoln Laboratory under Contract AF19(122)-45

Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set

BACKGROUND: A multi-cancer early detection (MCED) test used to complement existing screening could increase the number of cancers detected through population screening, potentially improving clinical outcomes. The Circulating Cell-free Genome Atlas study (CCGA; NCT02889978) was a prospective, case-controlled, observational study and demonstrated that a blood-based MCED test utilizing cell-free DNA (cfDNA) sequencing in combination with machine learning could detect cancer signals across multiple cancer types and predict cancer signal origin (CSO) with high accuracy. The objective of this third and final CCGA substudy was to validate an MCED test version further refined for use as a screening tool. PATIENTS AND METHODS: This pre-specified substudy included 4077 participants in an independent validation set (cancer: n = 2823; non-cancer: n = 1254, non-cancer status confirmed at year-one follow-up). Specificity, sensitivity, and CSO prediction accuracy were measured. RESULTS: Specificity for cancer signal detection was 99.5% [95% confidence interval (CI): 99.0% to 99.8%]. Overall sensitivity for cancer signal detection was 51.5% (49.6% to 53.3%); sensitivity increased with stage [stage I: 16.8% (14.5% to 19.5%), stage II: 40.4% (36.8% to 44.1%), stage III: 77.0% (73.4% to 80.3%), stage IV: 90.1% (87.5% to 92.2%)]. Stage I-III sensitivity was 67.6% (64.4% to 70.6%) in 12 pre-specified cancers that account for approximately two-thirds of annual USA cancer deaths and was 40.7% (38.7% to 42.9%) in all cancers. Cancer signals were detected across >50 cancer types. Overall accuracy of CSO prediction in true positives was 88.7% (87.0% to 90.2%). CONCLUSION: In this pre-specified, large-scale, clinical validation substudy, the MCED test demonstrated high specificity and accuracy of CSO prediction and detected cancer signals across a wide diversity of cancers. These results support the feasibility of this blood-based MCED test as a complement to existing single-cancer screening tests. CLINICAL TRIAL NUMBER: NCT02889978

Oenological characterisation of indigenous strains of S. cerevisiae isolated in a biodynamic winery in the Cortona DOC area

Genotypic and technological characterisation of the S. cerevisiae population isolated in a biodynamic winery in the Cortona DOC area was performed to gain better knowledge of the variables that influence winemaking. The oenological performance of 11 S. cerevisiae strains was evaluated with physiological tests; strain typing was performed through analysis of interdelta sequences and 26S rDNA sequencing. The analysis revealed a remarkable variability in terms of S. cerevisiae strains, despite the homogeneity of wine features, underlining the high levels of biodiversity characterising biodynamic agriculture. Some strains were found in wines of different vintages, suggesting the presence of an established microbiota in the winery. Oenological tests demonstrated that while some yeasts provided reliable oenological performance, other strains were not able to accomplish prompt and effective alcoholic fermentation, or were characterised by spoilage characteristics, such as excessive production of volatile phenols or acetic acid. Indigenous strains of S. cerevisiae could be a useful instrument for reliable winemaking without altering the native microbiota of each oenological environment. However, characterisation of their oenological suitability, and the application of practices able to drive the evolution of microbiota, must be employed to reduce the risk of wine spoilage