Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease

Cataloged from PDF version of article.Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. © 2013 Elsevier B.V

Knockout of 5-Lipoxygenase Results in Age-Dependent Anxiety-Like Behavior in Female Mice

The enzyme 5-lipoxygenase (5LO) has been implicated in a variety of neurological and psychiatric disorders including anxiety. Knockout of 5LO has previously been shown to alter anxiety-like behavior in mice at a young age but the effect of 5LO knockout on older animals has not been characterized.Here we used the elevated plus maze behavioral paradigm to measure anxiety-like behavior in female mice lacking 5LO (5LO-KO) at three different ages. Adolescent 5LO-KO animals did not significantly differ from wild-type (WT) animals in anxiety-like behavior. However, adult and older mice exhibited increased anxiety-like behavior compared to WT controls.These results indicate that 5LO plays a role in the development of the anxiety-like phenotype in an age-dependent manner in female mice. Future work should further investigate this interaction as 5LO may prove to be an important molecular target for the development of novel anxiolytic therapies

THE VALIDITY AND RELIABILITY STUDY OF THE PARENT AND CHILD FORMS OF THE PEDIATRIC PAIN COPING INVENTORY (PEDSQL-PPCI)

WOS: 00039004070147

DETERMINATION OF THE EFFECT OF BRAIN DOMINANCE ON ENTREPRENEURSHIP AND ASSERTIVENESS IN UNIVERSITY STUDENTS

WOS: 00039004070152

The influence on group games on the relationship between children with disabilities and their healthy siblings: An experimental study

Objective: To investigate the impact of group game activities among children with disabilities and their siblings. Method: This case-control study was conducted between July and September, 2015, at a rehabilitation centre in Zonguldak province, Turkey. The experimental group comprised children having disabilities, while the control group had healthy siblings and their mothers. The children were directed to play various games with their siblings over a period of four weeks, after which the instruments were administered once again. The groups were compared using Schaeffer Sibling Behaviour Rating Scale-Sibling's Form. SPSS 21 was used to analyse the data. Results: There were eight children each in the two groups with a mean age of 8.50±2.07 years in the experimental group and 8.37±2.32 years in the control group. A significant difference between the experimental (5.62±2.55) and control group (3.12±0.35) was only found in the sub-scale of physical aggression (p<0.05). Conclusion: The group activities had a positive effect on the children. © 2018, Pakistan Medical Association. All rights reserved

The use of complementary and alternative therapies in childhood cancer: A questionnaire based on a descriptive survey from the western black sea region of Turkey

Background: The objective of this study was to determine what complementary and alternative therapies are used in cases of childhood cancer, the frequency of their use and the factors that affect the tendency to resort to these therapies. Materials and Methods: The study, of cross-sectional design, was conducted with the parents of 101 children diagnosed with cancer, using a questionnaire and the technique of face-to-face interviews. Mean scores, percentages, chi-square and Kruskal-Wallis tests were used in the statistical analysis. During the study, interviews were held with 42.6% of the children's mothers and with the fathers of 44.6%. Results: The mean age of the children was 8.66±4.52 years. A group of 33.7% of the parents was making use of complementary and alternative medicine (CAM) for their children. Of the parents, 76.5% stated that CAM had been instrumental in reducing a tumor, 53.8% said that their child's general condition had improved and 15.4% expressed an increase in morale. Another 41.2% concealed their use of CAM from their doctors and nurses. The parents that were interviewed: the age of the mother, the age of the father and the family's economic status were determining factors in the parents' use of CAM. The prevalence of the use of CAM among parents with children with cancer is not negligible. Conclusion: It is the researchers' belief that health professionals must be informed about the use of CAM and its methods and that the patients should be evaluated with an impartial approach and given information about the use of CAM, together with conventional treatment.tudy was to determine what complementary and alternative therapies are used in cases of childhood cancer, the frequency of their use and the factors that affect the tendency to resort to these therapies. The study, of cross-sectional design, was conducted with the parents of 101 children diagnosed with cancer, using a questionnaire and the technique of face-to-face interviews. Mean scores, percentages, chi-square and Kruskal-Wallis tests were used in the statistical analysis. During the study, interviews were held with 42.6% of the children's mothers and with the fathers of 44.6%. The mean age of the children was 8.66±4.52 years. A group of 33.7% of the parents were making use of complementary and alternative medicine (CAM) for their children. Of the parents, 76.5% stated that CAM had been instrumental in reducing a tumor, 53.8% said that their child's general condition had improved and 15.4% expressed an increase in morale. Another 41.2% concealed their use of CAM from their doctors and nurses. The parent that was interviewed, the age of the mother, the age of the father and the family's economic status were determining factors in the parents' use of CAM. The prevalence of the use of CAM among parents with children with cancer is not negligible. It is the researchers' belief that health professionals must be informed about the use of CAM and its methods and that patients should be evaluated with an impartial approach and given information about the use of CAM, together with conventional treatment. © 2016, African Ethnomedicines Network. All rights reserved

THE EFFECT OF CLAY THERAPY ON THE QUALITY OF LIFE OF CHILDREN DIAGNOSED WITH CANCER

WOS: 00039004070130