Effects of Vitamin K-1 on fluoride-induced bone changes in growing rats: A histomorphometric and radiodensitometric study

WOS: 000232430300007PubMed ID: 16137498The aim of this study was to investigate the potential effects of Vitamin K-1 supplementation on skeletal changes related to fluoride in growing rats. Forty male Wistar rats aged 4 weeks were assigned at random into three groups: high-dose fluoride (125 ppm) group; high-dose fluoride + Vitamin K-1 (0.2 mg/(g day)) group; and a control group. The experimental period was 12 weeks. The L-3 vertebrae and the right tibiae were removed, and specimens were analysed by histologic and histomorphometric methods. Quantitative radiodensitometry was also employed to assess the differences in bone mineral density (BMD) between the groups. In the tibia, total tissue area was higher in the study groups than the control group (P < 0.05). Cortical bone area was slightly higher in the fluoride + K-1 group than the fluoride group, and marrow cavity area was lower in the fluoride + K-1 group (P < 0.05). In the L3 vertebral cancellous bone, bone volume, trabecular number and trabecular thickness were higher in the study groups than the control group (P < 0.05). Trabecular separation was reduced in the study groups (P < 0.05), and was lower in the fluoride + K-1 group than the fluoride group (P < 0.05). The fluoride + K-1 group had a significantly higher BMD than the other groups (P < 0.05), and the fluoride group had a significantly higher BMD than the control group (P < 0.05). The present study found that fluoride administration increased bone mass in both vertebrae and tibiae in growing rats. Simultaneous administration of Vitamin K-1 and fluoride resulted in an additional increase in vertebral bone mass. (c) 2005 Elsevier Ltd. All rights reserved

Histomorphometric evaluation of the effects of various diode lasers and force levels on orthodontic mini screw stability

PubMedID: 25594769The purpose of this study was to evaluate the effects of different laser dose and force levels on the stability of orthodontic mini screws used for anchorage, by histomorphometric analyses. Background data: Low-level laser therapy speeds up blood flow, improves the mechanism of the revitalization processes, reduces the risk of infection, boosts metabolic activities, and accelerates the healing of the damaged tissue. Although there are many research studies about low-level laser therapy applications in a variety of areas, no investigations were found concerning mini screw stability using various laser dose levels with different force level applications. Methods: Seventeen New Zealand white rabbits were used. A total of 68 cylindrical, self-drilling orthodontic mini screws were threaded at the fibula. Experimental subjects were divided into six groups; force application was not performed in the first three groups, whereas 150g of force was applied via nickel-titanium closed-coil springs placed between two mini screws in the other three groups. Measurements of the initial torque values (10 Ncm) were manipulated by a digital portable torque gauge. Various low-level laser doses were applied to the groups during the postoperative 10 days. After 4 weeks, bone-to-implant contact and cortical bone thickness were histomorphometrically analyzed. Results: In the 150g force plus 20 J/cm2 dosage group, the highest bone-to-implant contact values were observed. (p&lt;0.05) There were no statistically significant correlations between cortical bone thickness and bone-to-implant contact values; on the other hand, no significant difference was found among the same groups in terms of cortical bone thickness values (p&gt;0.05). Conclusions: Low-level laser therapy was noticed to induce the mini screw-bone contact area. Low-level laser therapy may be a supplementary treatment method to increase the stability of the orthodontic mini screw. © 2015 Mary Ann Liebert, Inc

Anorganic bovine-derived hydroxyapatite vs b-tricalcium phosphate in sinus augmentation: A comparative histomorphometric study

PubMedID: 23072285The choice of augmentation material is a crucial factor in sinus augmentation surgery. Bovine-derived hydroxyapatite (BHA) and beta-tricalcium phosphate (b-TCP) have been used successfully in sinus augmentation procedures. Choosing one of these materials for sinus augmentation is still controversial. The aim of this clinical study was to compare the biological performance of the new BHA graft material and the well-known synthetic b-TCP material in the sinus augmentation procedure. The study consisted of 23 patients (12 male and 11 female) who were either edentulous or partially edentulous in the posterior maxilla and required implant placement. A total of 23 two-step sinus-grafting procedures were performed. BHA was used in 13 patients, and b-TCP was used in 10 patients. After an average of 6.5 months of healing, bone biopsies were taken from the grafted areas. Undecalcified sections were prepared for histomorphometric analysis. The mean new bone formation was 30.13% 6 3.45% in the BHA group and 21.09% 6 2.86% in the b-TCP group (P=.001). The mean percentage of residual graft particle area was 31.88% 6 6.05% and 34.05% 6 3.01% for the BHA group and b-TCP group, respectively (P =.047). The mean percentage of soft-tissue area was 37.99% 6 5.92% in the BHA group and 44.86% 6 4.28% in the b-TCP group (P =.011). Both graft materials demonstrated successful biocompatibility and osteoconductivity in the sinus augmentation procedure. However, BHA appears to be more efficient in osteoconduction when compared with b-TCP

LUCAS POLYNOMIAL SOLUTION FOR NEUTRAL DIFFERENTIAL EQUATIONS WITH PROPORTIONAL DELAYS

This paper proposes a combined operational matrix approach based on Lucas and Taylor polynomials for the solution of neutral type differential equations with proportional delays. The advantage of the proposed method is the ease of its application. The method facilitates the solution of the given problem by reducing it to a matrix equation. Illustrative examples are validated by means of absolute errors. Residual error estimation is presented to improve the solutions. Presented in graphs and tables the results are compared with the existing methods in literature

Vitamin-K1 (Phylloquinone) prevents sodium-fluoride (NaF)-induced skeletal fluorosis.

WOS: 000202893600097

Kinesio Taping for temporomandibular disorders: Single-blind, randomized, controlled trial of effectiveness

PubMedID: 26966829BACKGROUND: Data regarding the effectiveness of Kinesio Taping in temporomandibular disorders (TMD) is scarce. OBJECTIVE: To determine the efficacy of Kinesio Taping (KT) in patients with TMD. METHODS: Patients with TMDs were randomized into experimental and control groups. The experimental group (n = 14) received KT in combination with counseling and jaw exercise, whilst controls (n = 14) were given the regimen of counseling and exercise alone. Jaw movements, Visual analogue scale (VAS) scores and self-reported measures (functional limitation and masticatory efficiency) were evaluated at baseline, first and sixth weeks of the treatment. Biobehavioral questionnaire was filled out at baseline and at sixth week. RESULTS: Active mouth opening improved more in the experimental group than controls (p = 0.003). In the experimental group, VAS for temporomandibular joint, masticatory efficiency and functional limitation improved significantly at the sixth week when compared to baseline (p = 0.011, p = 0.001 and p = 0.001, respectively), but not in controls. Subjective treatment efficacy was higher in the experimental group than that of controls (p = 0.000). Pain, depression and disability scores reduced significantly in the experimental group (p = 0.001, p = 0.006 and p = 0.01, respectively), but not in controls. CONCLUSION: In conclusion, KT in combination with counseling and exercise is more effective than counseling and exercise alone in TMDs. © 2016 - IOS Press and the authors. All rights reserved

Temporomandibular disorders in patients with rheumatoid arthritis: A clinical study

Objectives: The aim of this study is to evaluate the prevalence and type of temporomandibular disorders (TMD) in patients with rheumatoid arthritis (RA).Materials and Methods: Fifty‑four patients having RA treatment at Cukurova University in Rheumatology Clinic were enrolled to the study. Demographic and rheumatologic data were recorded. The patients were examined in Dental Faculty by using Research Diagnostic Criteria/TMD (RDC/TMD) axis I and answered RDC/TMD axis II Biobehavioral Questionnaire. Data were evaluated according instructions for scoring and assessment of RDC/TMD. Mann–Whitney test was performed to compare continuous variables between two groups and Kruskal–Wallis test was performed to compare continuous variables for more than two groups.Results: Although their activity situations were 55.6% active and 44.4% inactive, the distribution of treatment modality was 31.5% for anti‑tumor necrosis factor‑α (TNF‑α) and 68.5% for disease‑modifying antirheumatic drugs (DMARD). The distribution of temporomandibular joint (TMJ) involvement was; 9.3% with no involvement, 7.4% with joint involvement, 64.8% with muscular involvement, 18.5% with both muscular and joint involvement. Rheumatologic functional scores were (0) 3.7%, (1) 50%, (2) 38.9%, (3) 7.4%. Patients’ chronic pain was graded from 0 to 4 and the distribution was 3.7%, 24.1%, 20.4%, 31.5% and 20.4%, respectively. The mean duration of RA for anti‑TNF‑α (11.47 ± 7.67) was significantly higher compared with DMARD (7.09 ± 5.21) P = 0.040.Conclusion: There was a high prevalence of TMD in RA patients, and muscular involvement was the highest among the TMJ involvements. Thus, this study supports TMJ examination should be encouraged in the rheumatology settings.Keywords: Research Diagnostic Criteria, rheumatoid arthritis, rheumatologic functional score, temporomandibular joints, temporomandibular disorder

Temporomandibular disorders in patients with rheumatoid arthritis: A clinical study

PubMedID: 27811440Objectives: The aim of this study is to evaluate the prevalence and type of temporomandibular disorders (TMD) in patients with rheumatoid arthritis (RA). Materials and Methods: Fifty-four patients having RA treatment at Cukurova University in Rheumatology Clinic were enrolled to the study. Demographic and rheumatologic data were recorded. The patients were examined in Dental Faculty by using Research Diagnostic Criteria/TMD (RDC/TMD) axis I and answered RDC/TMD axis II Biobehavioral Questionnaire. Data were evaluated according instructions for scoring and assessment of RDC/TMD. Mann-Whitney test was performed to compare continuous variables between two groups and Kruskal-Wallis test was performed to compare continuous variables for more than two groups. Results: Although their activity situations were 55.6% active and 44.4% inactive, the distribution of treatment modality was 31.5% for anti-tumor necrosis factor-? (TNF-?) and 68.5% for disease-modifying antirheumatic drugs (DMARD). The distribution of temporomandibular joint (TMJ) involvement was; 9.3% with no involvement, 7.4% with joint involvement, 64.8% with muscular involvement, 18.5% with both muscular and joint involvement. Rheumatologic functional scores were (0) 3.7%, (1) 50%, (2) 38.9%, (3) 7.4%. Patients' chronic pain was graded from 0 to 4 and the distribution was 3.7%, 24.1%, 20.4%, 31.5% and 20.4%, respectively. The mean duration of RA for anti-TNF-? (11.47 ± 7.67) was significantly higher compared with DMARD (7.09 ± 5.21) P = 0.040. Conclusion: There was a high prevalence of TMD in RA patients, and muscular involvement was the highest among the TMJ involvements. Thus, this study supports TMJ examination should be encouraged in the rheumatology settings. © 2016 Nigerian Journal of Clinical Practice | Published by Wolters Kluwer - Medknow