BIOCONVERSION OF HEMICELLULOSE HYDROLYSATE OF SWEET SORGHUM BAGASSE TO ETHANOL BY USING PICHIA STIPITIS NCIM 3497 AND DEBARYOMYCES HANSENII SP.

Production of ethanol from concentrated D-xylose solutions and hemicellulose hydrolysate of sweet sorghum bagasse was achieved by using Pichia stipitis NCIM 3497 and an isolated yeast Debaryomyces hansenii sp. These yeasts were capable of producing ethanol from solutions containing 800 g/L D-xylose, and the optimum sugar concentration was found to be 150 g/L at pH 4, 30oC, with a production time of 72 hours. These yeasts were capable of utilizing multiple sugars. Hemicellulose hydrolysates of sweet sorghum bagasse were obtained by dilute acid hydrolysis and autohydrolysis including steam explosion treatment. The hydrolysate was treated by an over-liming process for detoxification and pH adjustment. Ethanol yield from hemicellulose hydrolysate was found to be higher than that of synthetic medium containing D-xylose. These yeasts can be used in production of ethanol from concentrated hemicellulose hydrolysates containing high pentose sugars obtained while treating lignocellulosic biomass at high substrate concentrations

β\beta-Ga2_2O3_3 Trench Schottky Diodes by Novel Low-Damage Ga-Flux Etching

$\beta$-Ga$_2$O$_3$ trench Schottky barrier diodes fabricated through a Gallium atomic beam etching technique, with excellent field strength and power device figure of merit, are demonstrated. Trench formation was accomplished by a low-damage Ga flux etch that enables near-ideal forward operating characteristics that are independent of fin orientation. The reverse breakdown field strength of greater than 5.10 MV/cm is demonstrated at breakdown voltage as of 1.45 kV. This result demonstrates the potential for Ga atomic beam etching and high-quality dielectric layers for improved performance in $\beta$-Ga$_2$O$_3$ vertical power devices.Comment: 10 pages, 5 figure

The Politics of Social Inclusion: Bridging Knowledge and Policies Towards Social Change

This volume looks at concepts and processes of social exclusion and social inclusion. It traces a number of discourses, all of them routed in a relational power analysis, examining them in the context of the UN Agenda for Sustainable Development 2030 with its commitment to "leave no one behind." The book combines analysis that is fundamentally critical of the rhetoric of social inclusion in academic and UN discourse with narratives of social exclusion processes and social inclusion contestation, based on ethnographic field research findings in La Paz, Kingston, Port-au-Prince, Kampala, Beijing, Chongqing, Mumbai, Delhi, and villages in Northern India. As a result, it contributes to revealing the politics of social inclusion, offering policy proposals towards overcoming exclusions.Comparative Research Programme on Poverty (CROP) at the University of Bergen.publishedVersio

Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit

Background: Endoscopy within 24 hours of admission (early endoscopy) is a quality standard in acute upper gastrointestinal bleeding (AUGIB). We aimed to audit time to endoscopy outcomes and identify factors affecting delayed endoscopy (>24h of admission).Methods: This prospective multicentre audit enrolled patients admitted with AUGIB who underwent inpatient endoscopy between Nov-Dec 2017. Analyses were performed to identify factorsassociated with delayed endoscopy, and to compare patient outcomes, including length of stay and mortality rates, between early and delayed endoscopy groups.Results: Across 348 patients from 20 centres, the median time to endoscopy was 21.2h (IQR 12.0- 35.7), comprising median admission to referral and referral to endoscopy times of 8.1h (IQR 3.7- 18.1) and 6.7h (IQR 3.0-23.1) respectively. Early endoscopy was achieved in 58.9%, although this varied by centre (range: 31.0% - 87.5%, p=0.002). On multivariable analysis, lower Glasgow-Blatchford score, delayed referral, admissions between 7am-7pm or via the Emergency Department were independent predictors of delayed endoscopy. Early endoscopy was associated with reduced length of stay (median difference 1d; p= 0.004), but not 30-day mortality (p=0.344).Conclusions: The majority of centres did not meet national standards for time to endoscopy. Strategic initiatives involving acute care services may be necessary to improve this outcome

Primary mature cystic teratoma with carcinoid mimicking an adrenal tumor: Report of a rare association and review of literature

Teratomas are neoplasms comprising of tissues derived from more than one germ layer. Most common sites are gonads, sacrococcygeal, mediastinal, retroperitoneal, and pineal region. Here, we report a case of 2 -year-old previously healthy female toddlerwho presented with fever and right upper quadrant abdominal pain. Magnetic resonance imaging (MRI) of the abdomen revealed a right suprarenal nonenhancing cystic mass. Focal calcification was seen in the inferomedial aspect of the cyst. Complete surgical resection of the right adrenal gland was done. The patient had an uneventful postoperative course and was free of recurrence at 8 months follow-up. Primary retroperitoneal teratomas of the adrenal gland are very uncommon (4% of all primary teratomas) and can mimic a primary adrenal tumor, hence should be included in the differential diagnosis of adrenal masses

Estimation of Carbon Footprint of Residential Building in Warm Humid Climate of India through BIM

In recent years Asian Nations showed concern over the Life Cycle Assessment (LCA) of their civil infrastructure. This study presents a contextual investigation of a residential apartment complex in the territory of the southern part of India. The LCA is performed through Building Information Modelling (BIM) software embedded with Environmental Product Declarations (EPDs) of materials utilized in construction, transportation of materials and operational energy use throughout the building lifecycle. The results of the study illustrate that cement is the material that most contributes to carbon emissions among the other materials looked at in this study. The operational stage contributed the highest amount of carbon emissions. This study emphasizes variation in the LCA results based on the selection of a combination of definite software-database combinations and manual-database computations used. For this, three LCA databases were adopted (GaBi database and ecoinvent databases through One Click LCA software), and the ICE database was used for manual calculations. The ICE database showed realistic value comparing the GaBi and ecoinvent databases. The findings of this study are valuable for the policymakers and practitioners to accomplish optimization of Greenhouse Gas (GHG) emissions over the building life cycle

Segmental colonoscopic biopsies in the differentiation of ileocolic tuberculosis from Crohn's disease

Background and Aim: The differentiation between Crohn's disease (CD) and tuberculosis (TB) of the intestine can be difficult in areas where both diseases occur. The present study examined histological criteria that would enable the diagnosis in mucosal biopsies. Methods: Colonoscopic biopsies from 33 patients with TB and 31 patients with CD were examined for several specific histological features and their distribution. Results: The salient distinguishing features of TB were granulomas larger than 400 μm in maximum dimension, more than four sites of granulomatous inflammation per site, caseation, a band of epithelioid histiocytes in ulcer bases and location of granulomas in the caecum. The salient features of CD were granulomas not showing any of the above features, focally enhanced colitis, pericryptal granulomatous inflammation, and the presence of architectural alteration/activity/chronic inflammation/deep ulceration at sites that did not show granulomatous response in the same or adjacent segments. Although granulomas in CD were distributed throughout the colon, they were more frequent in the rectosigmoid than in TB. All biopsies from endoscopically abnormal sites did not show distinguishing features of TB or CD, emphasizing the need for multiple biopsies. There was an accrual in the number of diagnoses made with increasing numbers of biopsies from rectum to ileum. Conclusions: Histology of mucosal biopsies can aid in the differentiation of TB from CD, but multiple biopsies from different colonic segments are important for complete evaluation

Gastrointestinal lymphomas: Pattern of distribution and histological subtypes: 10 years experience in a tertiary centre in South India

Background and Aim: Gastrointestinal tract (GIT) is one of the major sites of extra-nodal lymphomas constituting 10-15% of all non-Hodgkin′s lymphoma cases and about 30-40% of extra-nodal lymphomas. Considerable variation exists in the literature with respect to incidence of the various histological subtypes and sites of involvement. This study was undertaken to ascertain the anatomic distribution, histological subtypes and sites of all GIT lymphomas presenting to a tertiary referral hospital in southern India. Materials and Methods: The histological material of 361 patients over a period of 10 years (2001-2010), with histopathological diagnosis of lymphoma involving the GIT (both primary and secondary), was analyzed retrospectively. All lymphomas were reclassified according to the World Health Organization 2008 classification. Results: These 361 cases include 336 primary and 25 cases of lymphomas, where the involvement was secondary. Primary lymphomas consisted of 267 males (79.64%) and 68 females (20.24%) with a male:female ratio of 3.93:1. The mean age was 45 years (range 3-88). Diffuse large B-cell lymphoma (DLBCL) was the commonest subtype (222 cases; 66.71%), followed by low-grade marginal zone lymphoma of the mucosa associated lymphoid tissue (MALT) type (34 cases; 10.12%) and Burkitt′s lymphoma (35 cases; 10.48%). The commonest site was stomach (180 cases; 53.57%), followed by small intestine (79 cases; 23.51%) and large intestine (68 cases; 20.23%), respectively. There were some uncommon types of GIT lymphomas documented during the study. Conclusion: In this largest retrospective single centre study from India, we establish that the pattern of distribution of primary GIT lymphomas (PGLs) in India is similar to the western literature in that the stomach is the commonest site of PGL and DLBCL is the commonest histological subtype. Immunoproliferative small intestinal disease cases were seen in this study, which is uncommon in the west

PI Prob: A risk prediction and clinical guidance system for evaluating patients with recurrent infections.

BackgroundPrimary immunodeficiency diseases represent an expanding set of heterogeneous conditions which are difficult to recognize clinically. Diagnostic rates outside of the newborn period have not changed appreciably. This concern underscores a need for novel methods of disease detection.ObjectiveWe built a Bayesian network to provide real-time risk assessment about primary immunodeficiency and to facilitate prescriptive analytics for initiating the most appropriate diagnostic work up. Our goal is to improve diagnostic rates for primary immunodeficiency and shorten time to diagnosis. We aimed to use readily available health record data and a small training dataset to prove utility in diagnosing patients with relatively rare features.MethodsWe extracted data from the Texas Children's Hospital electronic health record on a large population of primary immunodeficiency patients (n = 1762) and appropriately-matched set of controls (n = 1698). From the cohorts, clinically relevant prior probabilities were calculated enabling construction of a Bayesian network probabilistic model(PI Prob). Our model was constructed with clinical-immunology domain expertise, trained on a balanced cohort of 100 cases-controls and validated on an unseen balanced cohort of 150 cases-controls. Performance was measured by area under the receiver operator characteristic curve (AUROC). We also compared our network performance to classic machine learning model performance on the same dataset.ResultsPI Prob was accurate in classifying immunodeficiency patients from controls (AUROC = 0.945; pConclusionArtificial intelligence methods can classify risk for primary immunodeficiency and guide management. PI Prob enables accurate, objective decision making about risk and guides the user towards the appropriate diagnostic evaluation for patients with recurrent infections. Probabilistic models can be trained with small datasets underscoring their utility for rare disease detection given appropriate domain expertise for feature selection and network construction