自然発症てんかんラット(SER)における海綿状脳症を伴うてんかんの原因遺伝子, tremorとzitterはシナプトブレビン2遺伝子とプリオン蛋白遺伝子とそれぞれ強く連鎖している。

本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである京都大学0048新制・課程博士博士(医学)甲第7060号医博第1956号新制||医||681(附属図書館)UT51-98-C173京都大学大学院医学研究科病理系専攻(主査)教授 川口 三郎, 教授 柴崎 浩, 教授 芹川 忠夫学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

Exact Dynamics of the SU(K) Haldane-Shastry Model

The dynamical structure factor $S(q,\omega)$ of the SU(K) (K=2,3,4) Haldane-Shastry model is derived exactly at zero temperature for arbitrary size of the system. The result is interpreted in terms of free quasi-particles which are generalization of spinons in the SU(2) case; the excited states relevant to $S(q,\omega)$ consist of K quasi-particles each of which is characterized by a set of K-1 quantum numbers. Near the boundaries of the region where $S(q,\omega)$ is nonzero, $S(q,\omega)$ shows the power-law singularity. It is found that the divergent singularity occurs only in the lowest edges starting from $(q,\omega) = (0,0)$ toward positive and negative q. The analytic result is checked numerically for finite systems via exact diagonalization and recursion methods.Comment: 35 pages, 3 figures, youngtab.sty (version 1.1

Multipole ordering in f-electron systems

In order to investigate multipole ordering in f-electron systems from a microscopic viewpoint, we study the so-called \Gamma_8 models on three kinds of lattices, simple cubic (sc), bcc, and fcc, based on a j-j coupling scheme with f-electron hopping integrals through (ff\sigma) bonding. From the \Gamma_8 model, we derive an effective model for each lattice structure by using the second-order perturbation theory with respect to (ff\sigma). By further applying mean-field theory to the effective model, we find a \Gamma_{3g} antiferro-quadrupole transition for the sc lattice, a \Gamma_{2u} antiferro-octupole transition for the bcc lattice, and a longitudinal triple-q \Gamma_{5u} octupole transition for the fcc lattice.Comment: 2 pages, 3 figure

Generation of Knockout Rats with X-Linked Severe Combined Immunodeficiency (X-SCID) Using Zinc-Finger Nucleases

Background: Although the rat is extensively used as a laboratory model, the inability to utilize germ line-competent rat embryonic stem (ES) cells has been a major drawback for studies that aim to elucidate gene functions. Recently, zinc-finger nucleases (ZFNs) were successfully used to create genome-specific double-stranded breaks and thereby induce targeted gene mutations in a wide variety of organisms including plants, drosophila, zebrafish, etc. Methodology/Principal Findings: We report here on ZFN-induced gene targeting of the rat interleukin 2 receptor gamma (Il2rg) locus, where orthologous human and mouse mutations cause X-linked severe combined immune deficiency (X-SCID). Co-injection of mRNAs encoding custom-designed ZFNs into the pronucleus of fertilized oocytes yielded genetically modified offspring at rates greater than 20%, which possessed a wide variety of deletion/insertion mutations. ZFN-modified founders faithfully transmitted their genetic changes to the next generation along with the severe combined immune deficiency phenotype. Conclusions and Significance: The efficient and rapid generation of gene knockout rats shows that using ZFN technology is a new strategy for creating gene-targeted rat models of human diseases. In addition, the X-SCID rats that were established in this study will be valuable in vivo tools for evaluating drug treatment or gene therapy as well as model systems for examining the treatment of xenotransplanted malignancies

Microscopic Aspects of Multipole Properties of Filled Skutterudites

We discuss low-temperature multipole states of Nd-based filled skutterudites by analyzing a multiorbital Anderson model with the use of a numerical renormalization group method. In order to determine the multipole state, we take a procedure to maximize the multipole susceptibility matrix. Then, it is found that the dominant multipole state is characterized by the mixture of 4u magnetic and 5u octupole moments. The secondary state is specified by 2u octupole. When we further take into account the coupling between $f$ electrons in degenerate $\Gamma_{67}^{-}$ ($e_{\rm u}$) orbitals and dynamical Jahn-Teller phonons with $E_{\rm g}$ symmetry, quadrupole fluctuations become significant at low temperatures in the mixed multipole state with 4u magnetic and 5u octupole moments. Finally, we briefly discuss possible relevance of the present results to actual Nd-based filled skutterudite compounds.Comment: 6 pages, 3 figures. To appear in the Proceedings of the 17th International Conference on Magnetism (ICM2006

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カフェイン酸フェネチルエステル（CAPE）がラット象牙芽細胞様細胞のVEGF発現と産生に与える影響

Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion. Odontoblasts located in the outermost layer of dental pulp play crucial roles such as production of growth factors and formation of hard tissue termed reparative dentin in host defense against dental caries. In this study, we investigated the effects of CAPE on the upregulation of vascular endothelial growth factor (VEGF) and calcification activities of odontoblasts, leading to development of novel therapy for dental pulp inflammation caused by dental caries. CAPE significantly induced mRNA expression and production of VEGF in rat clonal odontoblast-like KN-3 cells cultured in normal medium or osteogenic induction medium. CAPE treatment enhanced nuclear factor-kappa B (NF-κB) transcription factor activation, and furthermore, the specific inhibitor of NF-κB significantly reduced VEGF production. The expression of VEGF receptor- (VEGFR-) 2, not VEGFR-1, was up regulated in KN-3 cells treated with CAPE. In addition, VEGF significantly increased mineralization activity in KN-3 cells. These findings suggest that CAPE might be useful as a novel biological material for the dental pulp conservative therapy