Self-Propelled Carbohydrate-Sensitive Microtransporters with Built-In Boronic Acid Recognition for Isolating Sugars and Cells

A new nanomotor-based target isolation strategy, based on a “built-in” recognition capability, is presented. The concept relies on a poly(3-aminophenylboronic acid) (PAPBA)/Ni/Pt microtube engine coupling the selective monosaccharide recognition of the boronic acid-based outer polymeric layer with the catalytic function of the inner platinum layer. The PAPBA-based microrocket is prepared by membrane-templated electropolymerization of 3-aminophenylboronic acid monomer. The resulting boronic acid-based microengine itself provides the target recognition without the need for additional external functionalization. “On-the-fly” binding and transport of yeast cells (containing sugar residues on their wall) and glucose are illustrated. The use of the recognition polymeric layer does not hinder the efficient propulsion of the microengine in aqueous and physiological media. Release of the captured yeast cells is triggered via a competitive sugar binding involving addition of fructose. No such capture and transport are observed in control experiments involving other cells or microengines. Selective isolation of monosaccharides is illustrated using polystyrene particles loaded with different sugars. Such self-propelled nanomachines with a built-in recognition capability hold considerable promise for diverse applications

- 3 YAĞ ASİTLERİ : BİYOKİMYASAL VE POTANSİYEL KLİNİK ÖNEMİ

DİYETLE ALINAN BALIK YAĞINDA BULUNAN - 3 YAĞ ASİTLERİNİN SAĞLIK ÜZERİNE YARARLI ETKİLERİ KONUSU OLDUKÇA İLGİ ÇEKİCİDİR

BESİNSEL BALIK YAĞI ALINIMI VE EİKOSANOİD METABOLİZMASI ÜZERİNE ETKİLERİ

GEÇEN SON ÜÇ DEKAK BOYUNCA -3 YAĞ ASİTLERİNİN İNSAN BİYOLOJİSİ ÜZERİNE OLAN ETKİLERİ HAKKINDA PEK ÇOK BİLGİ ÖĞRENİLDİ

DNA Biosensors

WOS: 00035771850001

MoS2/Chitosan/GOx-Gelatin modified graphite surface: Preparation, characterization and its use for glucose determination

Graphene-like new generation of two dimensional (2D) nanomaterials, in particular the family of transition metal dichalcogenides (TMDCs) have been attracting a wide range of research interest. Among the family of TMDCs, molybdenum disulfide (MoS2) has been the most used one for biosensor applications. In this work, we detail the preparation of MoS2/chitosan composite modified pencil graphite electrode (MoS2/Chitosan/PGE) and its use as glucose biosensor after the modified electrode were immobilized with glucose oxidase (GOx)-gelatin (MoS2/Chitosan/GOx-Gelatin/PGE). This electrode was compared with the unmodified electrode in terms of electrochemical performance. Superior electrochemical responses were achieved including good electroactivity and sensitive glucose biosensing. For the MoS2/Chitosan/GOx-Gelatin modified PGE, a linear glucose concentration range was obtained from 10 mu M to 800 mu M with the equation of y = 0.0008x + 0.0547 (R2 = 0.9992) and a limit of detection (LOD) value of 3.18 mu M. The relative standard deviation (RSD%) was calculated as 3.77% at 200 mu M glucose (n = 5). The biosensor was tested in the presence of dopamine and ascorbic acid and our results presented the high selectivity of this novel MoS2/Chitosan/GOx-Gelatin modified PGE as a glucose biosensor