Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

Molecular groups of supratentorial ependymomas comprise tumors with ZFTA-RELA or YAP1-involving fusions and fusion-negative subependymoma. However, occasionally supratentorial ependymomas cannot be readily assigned to any of these groups due to lack of detection of a typical fusion and/or ambiguous DNA methylation-based classification. An unbiased approach with a cohort of unprecedented size revealed distinct methylation clusters composed of tumors with ependymal but also various other histological features containing alternative translocations that shared ZFTA as a partner gene. Somatic overexpression of ZFTA-associated fusion genes in the developing cerebral cortex is capable of inducing tumor formation in vivo, and cross-species comparative analyses identified GLI2 as a key downstream regulator of tumorigenesis in all tumors. Targeting GLI2 with arsenic trioxide caused extended survival of tumor-bearing animals, indicating a potential therapeutic vulnerability in ZFTA fusion-positive tumors

The Role of Creativity in Entrepreneurship

This paper evaluates the contribution of creativity to entrepreneurship theory and practice in terms of building an holistic and transdisciplinary understanding of its impact. Acknowledgement is made of the subjectivist theory of entrepreneurship which embraces randomness, uncertainty and ambiguity but these factors should then be embedded in wider business and social contexts. The analysis is synthesised into a number of themes, from consideration of its definition, its link with personality and cognitive style, creativity as a process and the use of biography in uncovering data on creative entrepreneurial behaviour. Other relevant areas of discussion include creativity’s link with motivation, actualisation and innovation, as well as the interrogation of entrepreneurial artists as owner/managers. These factors are embedded in a critical evaluation of how creativity contributes to successful entrepreneurship practice. Modelling, measuring and testing entrepreneurial creativity are also considered and the paper includes detailed consideration of several models of creativity in entrepreneurship. Recommendations for future theory and practice are also made

On Proving the Efficiency of Alternative RF Tests

ISBN 978-1-4577-1399-6International audienceThe deployment of alternative, low-cost RF test methods in industry has been, to date, rather limited. This is due to the potentially impaired ability to identify device pass/fail labels when departing from traditional specification test. By relying on alternative tests, pass/fail labels must be derived indirectly through new test limits defined for the alternative tests, which may incur error in the form of test escapes or yield loss. Clearly, estimating these test metrics as early as possible in the test development process is key to the success of an alternative test approach. In this work, we employ a test metrics estimation technique based on non-parametric kernel density estimation to obtain such early estimates, and, for the first time, demonstrate a real-world case study of test metric estimation efficiency at parts-per-million levels. To achieve this, we employ a set of more than 1 million RF devices fabricated by Texas Instruments, which have been tested with both traditional specification tests as well as alternative, low-cost On-chip RF Built-in Tests, or "ORBiTs"

PPM-Accuracy Error Estimates for Low-Cost Analog Test: A Case Study

International audienceOver the past decade, interest has increased in leveraging low-cost "alternate'' test methods as a drop-in replacement for testing analog and RF devices. The current practice for testing such devices, known as specification test, can be very expensive by comparison. By substituting less-costly alternate tests for specification test, substantial test cost reduction can be achieved. Despite this promised cost reduction, the testing community has been reluctant to adopt such alternate test methods in industrial settings, as the error incurred by alternate test can be quite difficult to capture. Estimating the expected test error metrics early in the fabrication process is, therefore, extremely desirable. In this work, we present a case study in which we investigate the reliability of kernel density estimation as a means of providing such early estimates of alternate test error. We also introduce the novel application of Laplacian score feature selection to identify key subsets of alternate tests. With these tools we are able to dramatically reduce the number of alternate tests applied, as well as predict test escape and yield loss error metrics within about 0.5% of their true values when evaluated on an industrial dataset with more than 1 million devices

Antarctic Ice Sheet response to a long warm interval across Marine Isotope Stage31: Across-latitudinal study of iceberg-rafted debris

Constraining the nature of Antarctic Ice Sheet (AIS) response to major past climate changes may provide a window onto future ice response and rates of sea level rise. One approach to tracking AIS dynamics, and differentiating whole system versus potentially heterogeneous ice sheet sector changes, is to integrate multiple climate proxies for a specific time slice across widely distributed locations. This study presents new iceberg-rafted debris (IRD) data across the interval that includes Marine Isotope Stage 31 (MIS 31: 1.081–1.062 Ma, a span of ∼19kyr; Lisiecki and Raymo, 2005), which lies on the cusp of the mid-Brunhes climate transition (as glacial cycles shifted from ∼41,000 yr to ∼100,000 yr duration). Two sites are studied—distal Ocean Drilling Program (ODP) Leg 177 Site 1090 (Site 1090) in the eastern subantarctic sector of the South Atlantic Ocean, and proximal ODP Leg 188 Site 1165 (Site 1165), near Prydz Bay, in the Indian Ocean sector of the Antarctic margin. At each of these sites, MIS 31 is marked by the presence of the Jaramillo Subchron (0.988–1.072Ma; Lourens et al., 2004) which provides a time-marker to correlate these two sites with relative precision. At both sites, records of multiple climate proxies are available to aid in interpretation. The presence of IRD in sediments from our study areas, which include garnets indicating a likely East Antarctic Ice Sheet (EAIS) origin, supports the conclusion that although the EAIS apparently withdrew significantly over MIS 31 in the Prydz Bay region and other sectors, some sectors of the EAIS must still have maintained marine margins capable of launching icebergs even through the warmest intervals. Thus, the EAIS did not respond in complete synchrony even to major climate changes such as MIS 31. Further, the record at Site 1090 (supported by records from other subantarctic locations) indicates that the glacial MIS 32 should be reduced to no more than a stadial, and the warm interval of Antarctic ice retreat that includes MIS 31 should be expanded to MIS 33-31. This revised warm interval lasted about 52 kyr, in line with several other interglacials in the benthic δ18Orecords stack of Lisiecki and Raymo(2005), including the super-interglacials MIS 11 (duration of 50 kyr) and MIS 5 (duration of 59 kyr). The record from Antarctica-proximal Site 1165, when interpreted in accord with the record from ANDRILL-1B, indicates that in these southern high latitude sectors, ice sheet retreat and the effects of warming lasted longer than at Site 1090, perhaps until MIS 27. In the current interpretations of the age models of the proximal sites, ice sheet retreat began relatively slowly, and was not really evident until the start of MIS 31. In another somewhat more speculative interpretation, ice sheet retreat began noticeably with MIS 33, and accelerated during MIS 31. Ice sheet inertia (the lag-times in the large-scale responses of major ice sheets to a forcing) likely plays an important part in the timing and scale of these events in vulnerable sectors of the AIS

Antarctic Ice Sheet response to a long warm interval across Marine Isotope Stage31: Across-latitudinal study of iceberg-rafted debris

Constraining the nature of Antarctic Ice Sheet (AIS) response to major past climate changes may provide a window onto future ice response and rates of sea level rise. One approach to tracking AIS dynamics, and differentiating whole system versus potentially heterogeneous ice sheet sector changes, is to integrate multiple climate proxies for a specific time slice across widely distributed locations. This study presents new iceberg-rafted debris (IRD) data across the interval that includes Marine Isotope Stage 31 (MIS 31: 1.081–1.062 Ma, a span of ∼19kyr; Lisiecki and Raymo, 2005), which lies on the cusp of the mid-Brunhes climate transition (as glacial cycles shifted from ∼41,000 yr to ∼100,000 yr duration). Two sites are studied—distal Ocean Drilling Program (ODP) Leg 177 Site 1090 (Site 1090) in the eastern subantarctic sector of the South Atlantic Ocean, and proximal ODP Leg 188 Site 1165 (Site 1165), near Prydz Bay, in the Indian Ocean sector of the Antarctic margin. At each of these sites, MIS 31 is marked by the presence of the Jaramillo Subchron (0.988–1.072Ma; Lourens et al., 2004) which provides a time-marker to correlate these two sites with relative precision. At both sites, records of multiple climate proxies are available to aid in interpretation. The presence of IRD in sediments from our study areas, which include garnets indicating a likely East Antarctic Ice Sheet (EAIS) origin, supports the conclusion that although the EAIS apparently withdrew significantly over MIS 31 in the Prydz Bay region and other sectors, some sectors of the EAIS must still have maintained marine margins capable of launching icebergs even through the warmest intervals. Thus, the EAIS did not respond in complete synchrony even to major climate changes such as MIS 31. Further, the record at Site 1090 (supported by records from other subantarctic locations) indicates that the glacial MIS 32 should be reduced to no more than a stadial, and the warm interval of Antarctic ice retreat that includes MIS 31 should be expanded to MIS 33-31. This revised warm interval lasted about 52 kyr, in line with several other interglacials in the benthic δ18Orecords stack of Lisiecki and Raymo(2005), including the super-interglacials MIS 11 (duration of 50 kyr) and MIS 5 (duration of 59 kyr). The record from Antarctica-proximal Site 1165, when interpreted in accord with the record from ANDRILL-1B, indicates that in these southern high latitude sectors, ice sheet retreat and the effects of warming lasted longer than at Site 1090, perhaps until MIS 27. In the current interpretations of the age models of the proximal sites, ice sheet retreat began relatively slowly, and was not really evident until the start of MIS 31. In another somewhat more speculative interpretation, ice sheet retreat began noticeably with MIS 33, and accelerated during MIS 31. Ice sheet inertia (the lag-times in the large-scale responses of major ice sheets to a forcing) likely plays an important part in the timing and scale of these events in vulnerable sectors of the AIS.Published109-1191A. Geomagnetismo e PaleomagnetismoJCR Journalrestricte

VFCVD diamond dental burs for improved performance

In this chapter the performance and life of dental burs coasted with diamond has been investigated. The performace of various diamond films using VFCDV and un-treated burs have been compared. Results show that the diamond coated burs using VFCVD performed better in terms of life

Silica-coating of nano-Y3Al5O12:Ce3+ synthesized by self-combustion

Y2.91Ce0.09Al5O12 is obtained by self-combustion, grinding and sol–gel coating. X-ray diffraction, transmission electron microscopy, photoluminescence and absorption measurements were used to identify the structural and optical properties of each step of the process. The process is composed of a combination of chemical and physico-chemical processesincluding combustion and thermal steps, followed by grinding, powder dispersion by acidic passivation, stabilization of particle dispersions with citrate ligands and embedding of yttrium aluminium garnet (YAG) particles into SiO2 shells usinga seeded growth process before drying. The initial state of the obtained powder is composed of 35 nm crystallites, sintered and agglomerated. The grinding step breaks the sintered bridge, while the passivation and citrate adsorption steps separate the particles by electrostatic repulsion before the silica coating. The optical characterizations are performed and compared separately for the powdered samples that represent the initial and final states of our process, and the dispersion sample represents the intermediate state of our process. The optical measurement revealed an important amount of optical defectsat the surface of the particles, compared with micrometric commercial particles. The grinding, nitric acid and citrate steps remove some of these defects. The final state of the sample still possesses lower quantum efficiency than that of a micrometric sample, but the SiO2 coating allows for a perfect separation of the particle, suitable for implementation in small devices