A practical one pot synthesis of 4-alkoxy-3-formylindoles

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

The Chemistry of Indoles. XXIV. Syntheses of 3-Indoleacetic Acid and 3-Indoleacetonitrile Having a Halogeno Group and a Carbon Functional Group at the 4-Position

Various 4-halogeno-3-indoleacetic acids and -3-indoleacetonitriles were synthesized for the first time by means of the Sandmeyer or Schiemann reaction, demonstrating the versatility of 4-indolediazonium salts in 4-substituted indole chemistry. A practical synthetic method for 4-halogenoindoles was developed by regio-selective thallation-halogenation, and the products were also led to 4-halogeno-3-indoleacetic acids. The first synthesis of 4-formyl-3-indoleacetonitrile is also reported

Successful Intervention for Descending Necrotizing Mediastinitis : A Case Report

Descending necrotizing mediastinitis(DNM) is a rare, however, highly fatal disease originating from odontogenic, pharyngeal, or cervical infectious sources that descend along facial planes into the mediastinum. We report a case who underwent surgical drainage using a mediastinoscope for the treatment of DNM and had successful postoperative course. Cervicothoracic CT should be performed immediately for diagnosis and for evaluating the extent of infection and necrosis, and effective drainage and debridement with suitable approach is required as soon as possible if DNM is suspected