Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility

Leuprolide is a gonadotropin-releasing hormone (GnRH) analog which has been shown to reduce symptoms in patients with irritable bowel syndrome (IBS) and chronic intestinal pseudo-obstruction (CIPO). The mechanism is not known, but one hypothesis is through down-modulation of luteinizing hormone (LH) secretion, a hormone whith antagonistic effect on gastrointestinal motility. However, presence of LH receptors in the gastrointestinal tract has never been described. The aim of this study was to find one possible way of action for leuprolide by examining the presence of the LH receptor, and if present, to see whether there was different expression in patients with or without dysmotility. Full-thickness biopsies from the bowel wall of patients with and without severe dysmotility were examined using immunohistochemistry staining. Biopsies showed expression of LH receptors on myenteric neurons and in glial cells, neutrophils, endothelial cells and mast cells. There was no difference in expression between patient groups

COMPARISON OF SINGLE-INCISION MIDURETHRAL SLING AND LAPAROSCOPIC BURCH COLPOSUSPENSION TECHNIQUES IN TERMS OF SURGICAL EFFECT AND SIDE EFFECT IN GENUINE STRESS URINARY INCONTINENCE SURGERY: A PROSPECTIVE RANDOMISED STUDY

COMPARISON OF SINGLE-INCISION MIDURETHRAL SLING AND LAPAROSCOPIC BURCH COLPOSUSPENSION TECHNIQUES IN TERMS OF SURGICAL EFFECT AND SIDE EFFECT IN GENUINE STRESS URINARY INCONTINENCE SURGERY: A PROSPECTIVE RANDOMISED STUDYVarious retropubic and midurethral sling techniques have shown high cure rates in the treatment ofstress urinary incontinence (SUI). Our aim in this study is to compare the effectiveness, patient satisfaction, and surgicalresults of single-incision midurethral sling (SIMS), defined as the third-generation midurethral sling, and laparoscopicBurch colposuspension (LBC) procedures in patients undergoing surgical treatment due to SUI.TEZ VERİLERİ (1).xls

Factors affecting pregnancy in IVF: Age and duration of embryo transfer

PubMedID: 20117051The aim of this retrospective study was to investigate factors affecting clinical pregnancy rates, especially age and duration of embryo transfer, in IVF/intracytoplasmic sperm injection cycles (1313 embryo transfers). Overall clinical pregnancy rate was 30.0% (n = 394). Clinical pregnancy rates were found to be 31.6% for the <44 s interval, 25.9% for the 45-59 s interval and 23.6% for the ?60 s interval (P = 0.020). In the <35 year age group, clinical pregnancy rates were 35.1%, 29.9% and 30.6%, and in the ?35 year age group, they were 26.9%, 21.0% and 13.4% (P = 0.013), respectively. According to logistic regression analyses, the odds of failed pregnancy increased by 1.61 times [95% confidence interval (CI) 1.07-2.41] for embryo transfer durations longer than 60 s and odds ratios of a failed pregnancy were 1.53 (95% CI 1.18-1.99) in the ?35 year age group, 1.49 (95% CI 1.05-2.12) for fewer than five oocytes and 3.38 (95% CI 2.10-5.43) for fewer than two transferred embryos. In conclusion, to increase the likelihood of a successful pregnancy in women over 35 years of age, the duration of embryo transfer must be kept below 60 s. The number of oocytes obtained and the number of transferred embryos also play a role in the success of pregnancy. © 2009, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved

Flight Control Law Design using Hybrid Incremental Nonlinear Dynamic Inversion

Incremental Nonlinear Dynamic Inversion (INDI) is a sensor-based control strategy, which has shown robustness against model uncertainties on various aerospace platforms. The sensor-based nature of the method brings attractive properties, which has made it popular in the last decade. INDI globally linearizes the system by making use of control input and state derivative feedback. Despite the enhanced robustness against parametric system uncertainties compared to traditional NDI, mitigating the effects of time lag between the control input and state derivative feedback paths represents an important challenge for INDI. Past research has shown that this can be addressed by synchronizing these feedback signals, although the method remains vulnerable to unexpected measurement delays. This paper proposes a hybrid INDI approach based on complementary filtering to further mitigate this robustness issue. The approach fuses the system model and sensor measurement to generate an estimate of the angular acceleration of the system. The estimation responds rapidly to the system input thanks to the on-board model, whereas adequate accuracy in the low-to-medium frequency range is maintained by the sensor measurement. The control law is found to retain good performance in case of model mismatches and measurement delays. To demonstrate the method, a hybrid INDI-based attitude control law is designed for a nonlinear F-16 aircraft model. The robustness properties of the resulting control system are analyzed using time-domain simulations.Control & Simulatio

Effect of Estrogen, Progesterone, LH, and FSH on Oxidant and Antioxidant Parameters in Rat Uterine Tissue

Background: To attain whether the effects of low and high doses of estrogen, progesterone, luteinizing hormone (LH), and follicle Stimulating hormone (FSH) in acute and chronic administration were related to oxidant and antioxidant parameters in rat uterine tissue as well as cyclooxygenase-1 (COX-1) activity