Ectopic Prostatic and Seminal Vesicle Tissue Confusing as Metastatic Adenocarcinoma

Ectopic prostatic tissue and seminal vesicle at pericolic fat is extremely rare. The nodules in the pericolic fat could raise a dilemma of metastatic deposits in cases of rectal adenocarcinoma. A 61 years old male underwent abdomino-perineal resection for rectal carcinoma. Nodules along with lymph nodes from pericolic fat were sampled to assess the spread. Histopathological and immunohistochemical staining of one nodule confirmed it to be the prostatic tissue while another nodule to be seminal vesicle. Seminal vesicle and prostatic heterotopia is significant in several respects, either symptomatic or asymptomatic, as the ectopic tissue can be endoscopically and histologically confused with malignancy of urinary or lower gastrointestinal system and may reflect divergent differentiation or a malformative process

Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes

The modulation of radiation induced lipid peroxidation in synaptosomes by iron (II) and iron (III) complexes of two naturally occurring and therapeutically relevant naphthoquinones viz. 5,hydroxy-1,4 naphthoquinone; juglone and 2,hydroxy-1,4 naphthoquinone; lawsone, have been studied. At lower concentrations the complexes enhance lipid peroxidation predominantly through redox cycling as observed for Fe(II)- juglonate while at higher concentrations the complexes tend to limit lipid peroxidation through fast recombinations

A short note on Magnetized Black-hole in Non-linear Electrodynamics

We have analyzed the thermodynamic properties of magnetized black-hole in the background of non-linear electrodynamics with two parameters $\beta$ and $\gamma$. We have studied the Bekenstein-Hawking entropy, Hawking temperature, specific heats in two-dimesional surface plots as a function of event horizon ($r_{+}$) and $\gamma$. We showed the variation profiles of the above thermodynamic parameters for $\gamma$ [$0 \rightarrow 1$]. We identified regions of parameters for the possible phase-transitions and the stability of the black-holes.Comment: 6 pages, 8 figure

Nearly Static Magnetized Kerr Black-hole in Non-linear Electrodynamics

We have analyzed the thermodynamics of slowly rotating magnetized Kerr black-hole, with typical spin parameter $a\le 0.1$ (nearly static) in the background of non-linear electrodynamics. In particular we have studied the Bekenstein-Hawking entropy, Hawking temperature, angular momentum, specific heats and identified regions of parameters for possible phase-transitions. It turns out that once the stability lost the black-hole never come back to its original stable position.Comment: 9pages, 12 figure

Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling

The DNA damage response (DDR) ensures cellular adaptation to genotoxic insults. In the crowded environment of the nucleus, the assembly of productive DDR complexes requires multiple protein modifications. How the apical E1 ubiquitin activation enzyme UBA1 integrates spatially and temporally in the DDR remains elusive. Using a human cell-free system, we show that poly(ADP-ribose) polymerase 1 promotes the recruitment of UBA1 to DNA. We find that the association of UBA1 with poly(ADP-ribosyl)ated protein–DNA complexes is necessary for the phosphorylation replication protein A and checkpoint kinase 1 by the serine/threonine protein kinase ataxia-telangiectasia and RAD3-related, a prototypal response to DNA damage. UBA1 interacts directly with poly(ADP-ribose) via a solvent-accessible and positively charged patch conserved in the Animalia kingdom but not in Fungi. Thus, ubiquitin activation can anchor to poly(ADP-ribose)-seeded protein assemblies, ensuring the formation of functional ataxia-telangiectasia mutated and RAD3-related-signalling complexes

SHORT TERM CRIME FORECASTING FOR PREVENTION OF CRIMES: A STUDY OF SATARA DISTRICT

Abstract: This research paper highlights the importance of crime forecasting in crime prevention in Satara District police station jurisdiction. Crime investigation and prevention has very significant role of police system in any country. The crime data has been stored and processed using Common Integrated Police Application [CIPA] and it become useful for getting the criminal information but it does not help for the purpose of designing an action to prevent the crime, it has become a major challenge for police system to detect and prevent crimes and criminals. There is no any kind of information is available before happening of such criminal acts and it result into increasing crime rate. The presented paper highlights the use of Forecasting technique to identify the crime in a specific area which can be useful for crime prevention

An assessment of attitudes towards plastics and bioplastics in Europe

Over the last 50 years, conventional fossil-based plastics have become an integral part of our everyday lives. Apart from their low production costs, this is due to a number of their unique properties, including durability, strength, lightness, electrical and thermal insulation, resistance to chemicals and corrosion. The production of plastics has increased from 1.5 million metric tons in 1950 to 359 million metric tons in 2018. Of this total, 61.8 million metric tons were produced in Europe. There are various problems associated with plastic use and disposal that pose a serious threat to both the physical environment and human health. Since public behaviour plays a key role when it comes to the use of plastic, this paper reports on a study that focused on an assessment of attitudes towards plastics and bioplastics in Europe. The results showed that packaging is the most frequent modality of plastic used among participants. In addition, majority of participants are aware that plastic waste can affect environment and human health and therefore segregate and properly dispose plastics. Also, even though most respondents were aware of the environmental problems related to plastic use and showed a positive inclination towards using bioplastic materials, their limited availability and lack of relevant information about bioplastics pose a problem for wider use. Departing from the assumption that the public attitude is a determining factor in the consumption of plastics as a whole and bioplastics in particular, this paper also sheds some light on the current situation, identifying some trends and information gaps which should be addressed in order to encourage a more rational use of plastics in Europe

Holistic Slowdown Driven Scheduling and Resource Management for Malleable Jobs

In job scheduling, the concept of malleability has been explored since many years ago. Research shows that malleability improves system performance, but its utilization in HPC never became widespread. The causes are the difficulty in developing malleable applications, and the lack of support and integration of the different layers of the HPC software stack. However, in the last years, malleability in job scheduling is becoming more critical because of the increasing complexity of hardware and workloads. In this context, using nodes in an exclusive mode is not always the most efficient solution as in traditional HPC jobs, where applications were highly tuned for static allocations, but offering zero flexibility to dynamic executions. This paper proposes a new holistic, dynamic job scheduling policy, Slowdown Driven (SD-Policy), which exploits the malleability of applications as the key technology to reduce the average slowdown and response time of jobs. SD-Policy is based on backfill and node sharing. It applies malleability to running jobs to make room for jobs that will run with a reduced set of resources, only when the estimated slowdown improves over the static approach. We implemented SD-Policy in SLURM and evaluated it in a real production environment, and with a simulator using workloads of up to 198K jobs. Results show better resource utilization with the reduction of makespan, response time, slowdown, and energy consumption, up to respectively 7%, 50%, 70%, and 6%, for the evaluated workloads

First report on induced spawning of Siganus vermiculatus in India

Siganids are widely distributed to Indo-West Pacific region and the Siganus vermiculatus (Maze rabbit fish/Vermiculated spinefoot) can reach sizes that weigh up 2.3 kg each. It is a species of great aquaculture importance and hence breeding and seed production protocols are necessary. A major breakthrough in the seed production of Siganus vermiculatus by inducing the fishes to spawn under controlled conditions with Human Chorionic Gonadotropin (hCG) during the first quarter of the lunar cycle is reported. The hatchery processes and early larval stages are described