Process study of a complex technology transfer and integration : the case of digital interactive broadcast media

Imperial Users onl

Gene expression analysis of pluripotency related genes in breast cancer after treatment with epigenetic drugs

Stem cells are the foundation stones upon which the entire developmental opera is enacted and the basis of cellular differentiation and functional specialization is laid down. The most important contributor in this act are the four core transcriptional regulators which stringently control the gene expression system to script a transcriptional program that maintains pluripotency and also guides cellular differentiation for functional phenotypes. The resultant transcriptional outcome is determined by epigenetic machinery. This system is also responsible for generating cancer stem cells which cause tumor resistance and recurrence. The present project is designed to study the epigenetic regulatory mechanism behind gene expression status of pluripotency genes –OCT4, SOX2, NANOG and KLF4 after treatment with various epigenetic modulators that affect cell growth and survival in breast cancer. The project will open up avenues for better management of caner and provide strategies for efficient cancer treatmen

Smart Aquaponics with Integration of AI and IoT for Yield Enhancement through Real-Time Monitoring and Decision Support

Technological advancements have become the key factor for major changes and upgradations in numerous industries and domain. Agriculture is no exception, technology stacks like IoT and AI are being integrated into agriculture up to a large extent starting from best crop prediction to crop health analysis, nutrient analysis to yield prediction. The intervention of technology is even more prominent in various smart agriculture methods including aquaponics, hydroponics, etc. Aquaponics is a sustainable method of agriculture, that combines aquaculture (fish farming) with hydroponics. This innovative system allows for the cultivation of fish and plants simultaneously, enabling a symbiotic relationship that enhances nutrient recycling. To lead the way for smart aquaponics, as technology continues to advance, the integration of artificial intelligence (AI) and the Internet of Things (IoT) holds immense potential for transforming traditional aquaponics into smart aquaponics. By harnessing real-time monitoring and decision support, AI and IoT can revolutionize various aspects of aquaponics that includes a major paradigm shift in agriculture, promising increased productivity, reduced resource usage, and improved environmental conservation. This article explores the transformative potential of leveraging AI and IoT technologies in aquaponics systems for yield enhancement, sustainability, and overall efficiency

Universality of the collapse transition of sticky polymers

The universality of the swelling of the radius of gyration of a homopolymer relative to its value in the $\theta$ state, independent of polymer-solvent chemistry, in the crossover regime between $\theta$ and athermal solvent conditions, is well known. Here we study, by Brownian dynamics, a polymer model where a subset of monomers is labelled as "stickers". The mutual interaction of the stickers is more attractive than those of the other ("backbone") monomers, and has the additional important characteristic of "functionality" $\varphi$, i.e., the maximum number of stickers that can locally bind to a given sticker. A saturated bond formed in this manner remains bound until it breaks due to thermal fluctuations, a requirement which can be viewed as an additional Boolean degree of freedom that describes the bonding. This, in turn, makes the question of the order of the collapse transition a non-trivial one. Nevertheless, for the parameters that we have studied (in particular, $\varphi=1$), we find a standard second-order $\theta$ collapse, using a renormalised solvent quality parameter that takes into account the increased average attraction due to the presence of stickers. We examine the swelling of the radius of gyration of such a sticky polymer relative to its value in the altered $\theta$ state, using a novel potential to model the various excluded volume interactions that occur between the monomers on the chain. We find that the swelling of such sticky polymers is identical to the universal swelling of homopolymers in the thermal crossover regime. Additionally, for our model, the Kuhn segment length under $\theta$ conditions is found to be the same for chains with and without stickers.Comment: 13 pages, 10 figures, supplementary material (see ancillary directory), to appear in Soft Matte

A COMPREHENSIVE REVIEW ON NOVEL MICROSPONGES DRUG DELIVERY APPROACH

ABSTRACTMicrosponges drug delivery approach (MDA) has been introduced in topical products to facilitate the controlled and targeted release of activedrug into the skin to decrease systemic exposure and minimize local cutaneous reaction. Microsponges are highly cross-linked, polymeric sponge,porous in nature, spherical shape consisting of high drug content within their interconnecting voids, releasing bioactive agent at a target site withinpredetermined time. They are mostly used for prolonged topical administration, enhanced efficacy for topically therapeutic agent with safety, stabilityand reduced side effects followed by improved aesthetic properties in an efficient and novel manner. More ever, it is found to be stable over wide pHrange and compatible with most vehicles. We here complied recent data regarding properties of microsponges, their methodology pharmaceuticalapplication and list of patent till date.Keywords: Microsponges, Bioactive, Porous, Interconnecting voids, Aesthetic

Luminance-Chrominance-Gradient Based Technique for High Dynamic Range Image Fusion

604-607The High Dynamic Range (HDR) technique involves capturing the same scene multiple times with different exposure values and produces an output image with more dynamic range. Instead of doing all processing in RGB color space, we proposed to do it in Luminance Chrominance Gradient colour space, which results the output images to be more natural and pleasant to perceive with less noise. This experiment was evaluated and analysed with BAR and AEE1 methods and the results are compared. We showed that, our LCGHDR method is computationally efficient and able to remove any colour distortions originated from the RGB color channel

The Control of DFIG for MPPT and application of STATCOM for grid stability

Themodeling, analysis, control and simulation of DFIG based WECS along with STATCOM implementation to the grid is presented in this paper. To maintain DC bus voltage the GVO control method is adopted in GSC for reactive power is provided. The efficient control of active and reactive power is provided through SVO scheme in RSC. The MPPT is achieved by keeping TSR to the optimum value.In this project implementation of STATCOM to grid system is shown in order to improve voltage stability during the grid disturbances. The three phase symmetrical fault is created in the distribution system and STATCOM which is connected to distribution system regulates the voltage drop and overcurrent to normal condition. The developed system is simulated for different wind speeds and allows power distribution system to be in-service during faults. The hardware prototype consists of voltage source converter and its controls are developed to verify the results