NEURO-ANATOMICAL EXPLANATION OF THE MODE OF ACTION OF AGNI KARMA IN PAIN MANAGEMENT OF MUSCULOSKELETAL DISORDERS

AgniKarma is a para-surgical procedure, Agni and Karma which means the Karma accomplished by the application of Agni (heat). According to Acharya Sushruta "The procedure in which the Samyaka Dagdha Vrana is produced by Agni is called the Agni Karma.It is frequently indicated in many musculoskeletal disorders like pain. Pain is a vital function of the nervous system in providing the body with a warning of potential or actual injury. Nociceptors are the free nerve endings of primary afferent A δ and C fibres. A δ and C fibres synapse with secondary afferent neurones in the dorsal horn of the spinal cord. Glycine and gamma-aminobutyric acid (GABA) are important neurotransmitters acting at inhibitory interneurons. The spinothalamic tract and the spinoreticular tract are the two main pathways that carry nociceptive signals to higher centres in the brain. On the basis of Ayurvedic Classics pain is caused by vitiated Vata Dosha and Agni Karma counter acts on it due to its Ushna Guna, as it is exactly opposite to Sheetaguna of Vata. This is supported by quotation of Yajurveda "Agni Himasya Bhaishja"

Delivery site preferences and associated factors among married women of Panauti Municipality, Kavrepalanchok district, Nepal

Introduction: Maternal mortality is a top global developmental agenda. The main cause of being underutilization of available delivery services especially in a developing country like Nepal. Various socio-demographic, socio-cultural and health service-related factors affect the utilization of these services. Thus, the study aims to identify the delivery site preferences and its associated factors among the married women of Panauti municipality of Kavrepalanchok district. Method: A cross-sectional study was conducted among the married women between the ages of 15-49 y residing in Panauti municipality. The face-to-face interviews were conducted using semi-structured questionnaires. The statistical analysis was done using Statistical Package for Social Sciences (SPSS) version 21. Result: A total of 106 women of 15-49 y were included in the study. The proportion of institutional delivery among the participants was 68%. 90.6% of total participants would prefer health facility for their future deliveries; 7.5% were not sure about their preferences and very few (1.9%) preferred to deliver at home. The factors like knowledge regarding safe-motherhood program and age at marriage were found to be significantly associated with their delivery site preference (p<0.05). Conclusion: In a country like Nepal, home delivery is still in practice and pregnancy and childbirth are regarded as normal life events. Thus, efforts should be made to change that perception, increasing utilization of available services and improving maternal and child health. This in turn will help to achieve the Sustainable Development Goal target in reducing the Maternal Mortality Rate

Traumatic abdominal wall hernia in two adults: a case series

<p>Abstract</p> <p>Introduction</p> <p>Traumatic hernia of the abdominal wall is a rare entity. A large proportion of reported cases are in children with a particular type of injury, i.e. from a handlebar injury. In adults, the presentation can vary substantially and the diagnosis is difficult. We present two cases in adults, with widely varying presentations and management.</p> <p>Case presentations</p> <p>A 40-year-old woman from rural north India presented with a low-velocity blunt injury to the lower abdomen. She was attacked by a bull. She had a clinically evident abdominal fascial disruption with intact skin, and was hemodynamically stable. An emergency mesh repair of the defect was performed, and she recovered well.</p> <p>A 38-year-old man from rural north India presented with blunt trauma to the abdomen following a motor vehicle accident. He was stable, with a central abdominal parietal wall swelling and bruising. A computed tomography scan revealed herniation of bowel loops in the area with minor intra-abdominal injuries. A laparotomy, resection-anastomosis of the ischemic bowel, and primary repair of the defect was performed and he recovered well.</p> <p>Conclusion</p> <p>Following blunt abdominal trauma, particularly high-velocity injuries, a high index of suspicion must be reserved for parietal wall swellings, as missed hernias in this setting have a high risk of strangulation. Computed tomography is the best aid to diagnosis. Management of each case needs to be individualized.</p

The Carpooling System

With the enormous increase in number of vehicles on road, people around the country especially in metro cities have started facing problem now due to increase in traffic which added an hour or so to their daily travelling time. Out of few, one of the methods to reduce this misery of travelers is to make them share cars. We intent to make an ANDROID application, carpooling, which is an application of car-sharing (also called lift-sharing or ride-sharing) in which drivers (alone-riders) who are traveling to work alone can ask for fellow passengers through our application. For those who use public-transport system to go to work daily can use this application to find drivers who are travelling to the same destination and willing to share ride. This will not only get rid of the extra journey time of passengers but will also help environment by reducing pollution and traffic on roads. This social networking application is also called fare-sharing and time sharing as you are you are sharing both with fellow travelers. This paper will also cover security issues with woman travelers in mind. DOI: 10.17762/ijritcc2321-8169.16044

First Record of Lantana Mealybug, Phenacoccus parvus Morrison (Hemiptera: Pseudococcidae), as a Pest on China Aster from South India

Heavy population of lantana mealybug,&nbsp;Phenacoccus parvus&nbsp;Morrison, was recorded on China aster,&nbsp;Callistephus chinensis&nbsp;(L.) Nees, in pest proportions at Bangalore, South India, both on the collar region and roots. About 25% of the plants were infested by the mealybug. Infested plants showed stunted growth and did not bear flowers seen in healthy plants. Field and mounted characters of&nbsp;P. parvus&nbsp;are presented in the pape

Establishing injury surveillance in emergency departments in Nepal: Protocol for mixed methods prospective study

Background: Globally, injuries cause more than 5 million deaths annually, a similar number to those from HIV, Tuberculosis and Malaria combined. In people aged between 5 and 44 years of age trauma is the leading cause of death and disability and the burden is highest in low- and middle-income countries (LMICs). Like other LMICs, injuries represent a significant burden in Nepal and data suggest that the number is increasing with high morbidity and mortality. In the last 20 years there have been significant improvements in injury outcomes in high income countries as a result of organised systems for collecting injury data and using this surveillance to inform developments in policy and practice. Meanwhile, in most LMICs, including Nepal, systems for routinely collecting injury data are limited and the establishment of injury surveillance systems and trauma registries have been proposed as ways to improve data quality and availability. Methods: This study will implement an injury surveillance system for use in emergency departments in Nepal to collect data on patients presenting with injuries. The surveillance system will be introduced in two hospitals and data collection will take place 24 h a day over a 12-month period using trained data collectors. Prospective data collection will enable the description of the epidemiology of hospital injury presentations and associated risk factors. Qualitative interviews with stakeholders will inform understanding of the perceived benefits of the data and the barriers and facilitators to embedding a sustainable hospital-based injury surveillance system into routine practice. Discussion: The effective use of injury surveillance data in Nepal could support the reduction in morbidity and mortality from adult and childhood injury through improved prevention, care and policy development, as well as providing evidence to inform health resource allocation. This study seeks to test a model of injury surveillance based in emergency departments and explore factors that have the potential to influence extension to additional settings

Ayurveda and Siddha systems polyherbal formulations to treat COVID-19 caused by SARS-CoV-2 and brief insight on application of Molecular Docking and SWISS Target prediction tools to study efficacy of active molecules

Ayurveda and  Siddha systems are the two ancient medical systems originated in India more than 4000 years ago had given many formulary and treatment methods against influenza like infections. Kabasura churan from Siddha system and Maha sudharshan churan from the Ayurvedic system are the two major formulations along with many other individual herbs mentioned in the texts to treat Influenza like infections. Kabasura churan and Maha Sudarshan churan both have antipyretic, analgesic and anti-inflammatory effects. Both formulations were prepared according to Siddha and Ayurvedic texts. Herbs mentioned in both formulations like Turmeric, Tulsi (Basil), Kalmegh (Andrographis), Black Pepper, Liquorice (Mulethi), and Dronapushpi (Leucas) etc., had direct antiviral effect. Herbs like Aswagandha, Ginger, Guduchi (Tinospora), Kulanjan (Galangal) etc., had immunomodulatory and anti-inflammatory effect. Active compounds from different herbs were selected to study their antiviral activity through molecular docking algorithm. Application of modern of tools like Bioinformatics and Highthroughput screening methods can predict the efficacy of the ancient documented formulations and can be compared as per their literature. Compounds like curcumin, Glycyrrhizin, Ursolic acid, Quercetin, Andrographolide, Coumarins etc. were showed polyspecific activity like inhibition of Spike protein, Furin, Main Protease (Mpro) and Papain like Proteases (PLpro). Thus we propose use of Kabasura churan and Maha Sudharshan churan as alternative complementary medicine as a palliative treatment against COVID-19 caused by SARS-CoV-2 by conducting proper Randomized Clinical Trial

Neodymium Isotope Constraints on the Origin of TTGs and High-K Granitoids in the Bundelkhand Craton, Central India : Implications for Archaean Crustal Evolution

The Bundelkhand craton in central India consists mainly of abundant high-K granitoids formed at the Archaean-Proterozoic boundary and several enclosed rafts of TTGs (tonalite-trondhjemite-granodiorites) up to 3.5 Ga. Therefore, the Bundelkhand craton is a key locality for studies on Archaean crustal growth and the emergence of multisource granitoid batholiths that stabilised a supercontinent at 2.5 Ga. Based on their geochemical characteristics, the high-K granitoids are divided into low silica-high Mg (sanukitoids and hybrids) and high silica-low Mg (anatectic) groups. We aim to provide new insights into the role of juvenile versus crustal sources in the evolution of the TTG, sanukitoid, hybrid, and anatectic granitoids of the Bundelkhand craton by comparing their key geochemical signatures with new Nd isotope evidence on crustal contributions and residence times. The ages and geochemical signatures as well as epsilon Nd(t) values and Nd model ages of TTGs point towards partial melting of a juvenile or short-lived mafic crust at different depths. Paleoarchaean TTGs show short crustal residence times and contributions from the newly formed crust, whereas Neoarchaean TTGs have long crustal residence times and contributions from the Paleoarchaean crust. This may reflect the transition from melting in a primitive oceanic plateau (3.4-3.2 Ga) in plume settings, resulting in a Paleoarchaean protocontinent, to 2.7 Ga subduction and island arc accretion along the protocontinent. The 2.5 Ga high-K granitoids formed at convergent subduction settings by partial melting of the mantle wedge and preexisting crust. Sanukitoids and hybrid granitoids originated in the mantle, the latter showing stronger crustal contributions, whereas abundant anatectic granitoids were products of pure crustal melting. Our Nd data and geochemical signatures support a change from early mafic sources to strong crust-mantle interactions towards the A-P boundary, probably reflecting the onset of supercontinent cycles.Peer reviewe