Modeling and Simulation of Multi-tier Enterprise IT System

This paper discusses modelling and simulation of multi-tier enterprise IT system. The layers in multi-tier architecture consist of web layer, application layer and database layer. Entities in the multi-tier system have been abstracted out into 3 categories- consumer, resource and router. Existing modelling and simulation frameworks for multi-tier systems focus on power management or performance of load balancing algorithms. Our framework enables seamless modelling, simulation, and experimentation of a wide range of what-if scenarios in multi-tier systems while encapsulating all the variations that arise due to configuration, composition, design and deployment. As an illustration, we discuss and simulate prediction of bottleneck scenario with results

Comparative analysis of medical pharmacology books based on competency based undergraduate curriculum followed by MBBS student in Rani Durgavati Medical College, Banda

Background: National Medical Commission (NMC) has implemented competency based undergraduate curriculum for training of new M.B.B.S. students. As per these curriculum authors of Medical Pharmacology books also changed their book content to fulfill the subject requirement.Methods: A systematic comparison of books carried out in department of pharmacology Rani Durgawati Medical College, Banda, Uttar Pradesh. There was comparison of 5 books of medical pharmacology of Indian author belongs to edition after 2019. The books included were Essentials of Medical Pharmacology (Jaypee Publication, 8th Edition, 2021), Medical Pharmacology (CBS Publishers And Distributors Pvt Ltd, 7th Edition, 2021), Pharmacology and Pharmacotherepeutics (Elsvier Publication, 26th Edition, 2021), Pharmacology for MBBS (Avichal Publication Company, 2nd edition, 2021) and Pharmacology for Medical Graduates (Elsvier Publication, 4th Edition, 2020). All the books were examined for the competencies described in the pharmacology syllabus. The table was prepared for the availability of topics according to the competencies of different section of syllabus. The chapter/page numbers mentioned in competency table were looked upon for the respective competencies and presence or absence of the topic was noted down.Results: All the books mainly covered competency given in the knowledge section of the syllabus. Few competencies in skill and communication sections were also covered in the text books.Conclusions: When all the five books were evaluated according to pharmacology competency in syllabus, none of the books covered whole pharmacology syllabus. This may be because authors considered the competency topics in skill and communication section as a part of practical or because many practical books or manuals are available in the market which covered topics in these sections

Evaluation of serum lipids in preeclampsia: a comparative study

Background: Preeclampsia occurs in 7 to 10% of pregnancies worldwide. At present most, popular theory is an oxidative stress. Abnormal lipid profiles and species may have a role in promotion of oxidative stress and vascular dysfunction seen in pre-eclampsia. Objectives of this study was carried out to evaluate lipid profile in subjects with preeclampsia and to compare lipid profile in subjects of preeclampsia as compared to normal pregnant women.Methods: A comparative longitudinal study was conducted under the tertiary care hospital setting over a period of one year where 440 study subjects were enrolled out of which 220 subjects were pre-eclamptic and 220 subjects were normotensive with gestation of 28 weeks to till term. Lipid profiling was done in all the subjects.Results: The mean serum levels of total cholesterol (198.5±18.91), HDL (50.63±9.35), LDL (84.5±16.16), VLDL (42.75±4.72) and TGA (74.92±11.95) were higher in pre-eclampsia group compared to normotensive group and this difference in the levels of lipid parameters was found to be statistically significant.Conclusions: Dyslipidemia is significantly evident in preeclampsia and plays an important role in its pathogenesis

Structure and Function of Methyltransferases from antibiotic resistance Bacteroides of human intestine and a study on Nm/Ng with CaM

Ph.DDOCTOR OF PHILOSOPH

Netlogo simulation: effective for agent based modeling in artificial intelligence

Today practical knowledge is as important as theretical knowledge. But the cost of setting up practical l abs is not easy and needs maintenance on a regular basis. But with the emergence of many simulators, practical knowledge can be imparted throug h setting up of virtual laboratories with the help of computers. The cost of maintenance also decreases to alarge extend. Our paper focuses on one such simulator named NETLOGO. NETLOGO is immergingsimulation software for agent based modeling. Itis easilyinstallable in a machine and can be downloaded from the net. It is free software. This paper deals with the usage of NETLOGO from both student and professors perspectives. The paper will state the advantages and disadvantages of the simulator along with a simulation example. Though there are many agent based programming l anguages yet our paper is trying to show the effectiveness of using NETLOGO as asimulator for agent based modeling

Providing Customized Requirements for Privacy Preserving In Web Search Engines

Web search tools are generally used to get information from web servers. These web crawlers use client profiles and as of late sought information to give indexed lists, so here there is no security insurance for client information. We give an framework that can assist clients with customizing their protection necessities. The protections prerequisites gave by client are utilized here for querying the Web server with the hunt keys given by client. In this methodology we can ready to conceal the protection information of client from web search servers. The procedure of modifying protection necessities will happen in offline and will be utilized dynamically .The calculations utilized here will give speculation inquiries expected to look by safeguarding security prerequisites gave. The Experimental results will prove that this Framework will ensure privacy of client

Certified Learning Experiences: From Heterogeneous Learning Spaces to Portable Education Portfolios

The digital era has accomplished new kinds of learning spaces, where learners engage in different kinds of learning activities. Thus different learners are gaining various learning experiences from heterogeneous learning spaces. A key challenge is how to systematically collect those heterogeneous learning activities into well-organized education portfolios. In existing Education Portfolio Systems (EPS) including LinkedIn, Mahara, and Open-Badges does not support importing learning activities from learning spaces. In these systems, it does not allow users to authenticate through OpenID, and also users cannot create multiple portfolio views. Thus to address these problems we propose our system named Portable Education Portfolios (PEPs) which imports certified users experiences from different learning spaces. This thesis utilizes a Design Science Research Methodology (DSRM) for PEPs development, which intends to solve the key challenge. The proposed approach i.e. DSRM is modified to fit this research context. As a result, alike existing EPS, an innovative IT artifact called PEPs tool is created. PEPs collect certified experiences of users from different learning spaces and also create their portfolio. On the other hand, as an additional feature to existing EPS, the PEPs tool supports Life-Long Learning Process and Continuing Professional Development. To address the research objectives PEPs system is experimented with three different learning spaces including TUT-Mantis, Moodle and OpenSE. These learning spaces follow informal, formal and non-formal learning patterns respectively. PEPs successfully collected various user experiences and created a single portable portfolio for the users. Hence, we conclude that the PEPs system is a complete tool to solve all the key issues raised in this research

A Conformational Switch in the Active Site of BT_2972, a Methyltransferase from an Antibiotic Resistant Pathogen B. thetaiotaomicron

Methylation is one of the most common biochemical reactions involved in cellular and metabolic functions and is catalysed by the action of methyltransferases. Bacteroides thetaiotaomicron is an antibiotic-resistant bacterium that confers resistance through methylation, and as yet, there is no report on the structure of methyltransferases from this bacterium. Here, we report the crystal structure of an AdoMet-dependent methyltransferase, BT_2972 and its complex with AdoMet and AdoHcy for B. thetaiotaomicron VPI-5482 strain along with isothermal titration calorimetric assessment of the binding affinities. Comparison of the apo and complexed BT_2972 structures reveals a significant conformational change between open and closed forms of the active site that presumably regulates the association with cofactors and may aid interaction with substrate. Together, our analysis suggests that BT_2972 is a small molecule methyltransferase and might catalyze two O-methylation reaction steps involved in the ubiquinone biosynthesis pathway

Governance Policies in IT Service Support

IT Service support provider, whether outsourced or kept in-house, has to abide by the Service Level Agreements (SLA) that are derived from the business needs. At the heart of IT Service support provider are the human resources that are expected to resolve tickets. It is essential that the policies, which govern the tickets’ movement amongst these resources, follow the business objectives such as service availability and cost reduction. In this study, we propose an agent based model that represents an IT Service Support system. A vital component in the model is the agent ‘Governor’, which makes policy decisions based on the by reacting to changes in the environment. The paper also studies the impact of various behavioural attributes of the Governor on the service objectives

Squamous Cell Carcinoma: Esophagus

Esophageal cancer, according to GLOBOCAN 2018 data, ranks seventh in terms of incidence and sixth in mortality among all cancers worldwide. In India, it is considered the fourth most common cause of cancer-related deaths. Influenced by lifestyle, socioeconomic and environmental factors, striking geographic variations in incidence exist. With regard to histopathology, esophageal cancers are unique among malignancies of the gastrointestinal tract in that they principally comprise two variants: squamous cell carcinoma (SCC) and adenocarcinoma, with the former accounting for up to 80% of cases. Etiological factors for SCC show marked variations worldwide, with tobacco consumption, alcohol, hot beverages, and poor nutrition constituting the predominant predisposing factors. Although present day therapeutic interventions have begun to positively influence disease prognosis, with significant improvements in survival noted over the last 3 decades, cancer of the esophagus remains a highly lethal disease with a case fatality rate approaching 90%. Management of this disease includes all three primary modalities of treatment; surgery, chemotherapy and radiotherapy. Surgical resection, the only curative modality of treatment, remains a challenge even with advances like minimal access surgery and is feasible only in early stage disease. Early diagnosis and accurate staging are paramount for optimizing treatment and hence, prognosis