Semiclassical Spectral Series Localized on a Curve for the Gross–Pitaevskii Equation with a Nonlocal Interaction

We propose the approach to constructing semiclassical spectral series for the generalized multidimensional stationary Gross–Pitaevskii equation with a nonlocal interaction term. The eigenvalues and eigenfunctions semiclassically concentrated on a curve are obtained. The curve is described by the dynamic system of moments of solutions to the nonlocal Gross–Pitaevskii equation. We solve the eigenvalue problem for the nonlocal stationary Gross–Pitaevskii equation basing on the semiclassical asymptotics found for the Cauchy problem of the parametric family of linear equations associated with the time-dependent Gross–Pitaevskii equation in the space of extended dimension. The approach proposed uses symmetries of equations in the space of extended dimension

Hematopoietic stem cell transplantation for adolescents and adults with inborn errors of immunity: an EBMT IEWP study.

peer reviewedAllogeneic hematopoietic stem cell transplantation (HSCT) is the gold standard curative therapy for infants and children with many inborn errors of immunity (IEI), but adolescents and adults with IEI are rarely referred for transplant. Lack of published HSCT outcome data outside small, single-center studies and perceived high risk of transplant-related mortality have delayed the adoption of HSCT for IEI patients presenting or developing significant organ damage later in life. This large retrospective, multicenter HSCT outcome study reports on 329 IEI patients (age range, 15-62.5 years at HSCT). Patients underwent first HSCT between 2000 and 2019. Primary endpoints were overall survival (OS) and event-free survival (EFS). We also evaluated the influence of IEI-subgroup and IEI-specific risk factors at HSCT, including infections, bronchiectasis, colitis, malignancy, inflammatory lung disease, splenectomy, hepatic dysfunction, and systemic immunosuppression. At a median follow-up of 44.3 months, the estimated OS at 1 and 5 years post-HSCT for all patients was 78% and 71%, and EFS was 65% and 62%, respectively, with low rates of severe acute (8%) or extensive chronic (7%) graft-versus-host disease. On univariate analysis, OS and EFS were inferior in patients with primary antibody deficiency, bronchiectasis, prior splenectomy, hepatic comorbidity, and higher hematopoietic cell transplant comorbidity index scores. On multivariable analysis, EFS was inferior in those with a higher number of IEI-associated complications. Neither age nor donor had a significant effect on OS or EFS. We have identified age-independent risk factors for adverse outcome, providing much needed evidence to identify which patients are most likely to benefit from HSCT

Rare Earth Elements in the Lignite Ash Determination Method Development

Показано, что зола лигнитов бассейна среднего течения р. Енисей может рассматриваться как сырьевой источник редкоземельных элементов. Разработана методика атомно-эмиссионного с индуктивно связанной плазмой определения редкоземельных элементов в золе лигнита Касского месторождения. Выявлено, что суммарное содержание РЗЭ составляет от 300 до 2500 г/тThe possibility of using the lignite ash from central watershed of the Yenisei river as a new rare earth elements raw material source was shown. Lignite ash rare earth elements inductively coupled plasma atomic emission spectroscopy determination method was developed. It was found that total concentration of rare earth elements in the ash is from 300 to 2500 g/

Rare Earth Elements in the Lignite Ash Determination Method Development

Показано, что зола лигнитов бассейна среднего течения р. Енисей может рассматриваться как сырьевой источник редкоземельных элементов. Разработана методика атомно-эмиссионного с индуктивно связанной плазмой определения редкоземельных элементов в золе лигнита Касского месторождения. Выявлено, что суммарное содержание РЗЭ составляет от 300 до 2500 г/тThe possibility of using the lignite ash from central watershed of the Yenisei river as a new rare earth elements raw material source was shown. Lignite ash rare earth elements inductively coupled plasma atomic emission spectroscopy determination method was developed. It was found that total concentration of rare earth elements in the ash is from 300 to 2500 g/

HIV-1 Drug Resistance among Treatment-Naïve Patients in Russia: Analysis of the National Database, 2006–2022

In Russia, antiretroviral therapy (ART) coverage has significantly increased, which, in the absence of routine genotyping testing, could lead to an increase in HIV drug resistance (DR). The aim of this study was to investigate the patterns and temporal trends in HIV DR as well as the prevalence of genetic variants in treatment-naïve patients from 2006 to 2022, using data from the Russian database (4481 protease and reverse transcriptase and 844 integrase gene sequences). HIV genetic variants, and DR and DR mutations (DRMs) were determined using the Stanford Database. The analysis showed high viral diversity, with the predominance of A6 (78.4%), which was the most common in all transmission risk groups. The overall prevalence of surveillance DRMs (SDRMs) was 5.4%, and it reached 10.0% in 2022. Most patients harbored NNRTI SDRMs (3.3%). The prevalence of SDRMs was highest in the Ural (7.9%). Male gender and the CRF63_02A6 variant were association factors with SDRMs. The overall prevalence of DR was 12.7% and increased over time, primarily due to NNRTIs. Because baseline HIV genotyping is unavailable in Russia, it is necessary to conduct surveillance of HIV DR due to the increased ART coverage and DR prevalence. Centralized collection and unified analysis of all received genotypes in the national database can help in understanding the patterns and trends in DR to improve treatment protocols and increase the effectiveness of ART. Moreover, using the national database can help identify regions or transmission risk groups with a high prevalence of HIV DR for epidemiological measures to prevent the spread of HIV DR in the country

Combination of Organic‐Based Reservoir Computing and Spiking Neuromorphic Systems for a Robust and Efficient Pattern Classification

Nowadays, neuromorphic systems based on memristors are considered promising approaches to the hardware realization of artificial intelligence systems with efficient information processing. However, a major bottleneck in the physical implementation of these systems is the strong dependence of their performance on the unavoidable variations (cycle‐to‐cycle, c2c, or device‐to‐device, d2d) of memristive devices. Recently, reservoir computing (RC) and spiking neuromorphic systems (SNSs) are separately proposed as valuable options to partially mitigate this problem. Herein, both approaches are combined to create a fully organic system based on 1) volatile polyaniline memristive devices for the reservoir layer and 2) nonvolatile parylene memristors for the SNS readout layer. This combination provides a simpler SNS training procedure compared with the formal neural networks and results in greater robustness to device variability, while ensuring the extraction and encoding of the input critical features (performed by the polyaniline reservoir) and the analysis and classification performed by the SNS layer. Furthermore, the spatiotemporal pattern recognition of the system brings us closer to the implementation of efficient and reliable brain‐inspired computing systems built with partially unreliable analog elements

The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation : a study from the EBMT Transplant Complications Working Party

Obesity and diabetes can modulate immune responses, which may impact allogeneic HCT outcomes and GvHD. From the EBMT registry, we included 36,539 adult patients who underwent allogeneic HCT for a hematological malignancy between 2016 and 2020. Of these, 5228 (14%) had obesity (BMI >= 30 kg/m(2)), 1415 (4%) had diabetes (requiring treatment with insulin or oral hypoglycemics), and 688 (2%) had obesity + diabetes pre-transplantation. Compared with patients without diabetes or obesity, the hazard ratio (HR) of grade II-IV acute GvHD was 1.00 (95% confidence interval [CI] 0.94-1.06, p = 0.89) for patients with obesity, 0.95 (CI 0.85-1.07, p = 0.43) for patients with diabetes, and 0.96 (CI 0.82-1.13, p = 0.63) for patients with obesity + diabetes. Non-relapse mortality was higher in patients with obesity (HR 1.08, CI 1.00-1.17, p = 0.047), diabetes (HR 1.40, CI 1.24-1.57, p < 0.001), and obesity + diabetes (HR 1.38, CI 1.16-1.64, p < 0.001). Overall survival after grade II-IV acute GvHD was lower in patients with diabetes (HR 1.46, CI 1.25-1.70, p < 0.001). Pre-transplantation diabetes and obesity did not influence the risk of developing acute GvHD, but pre-transplantation diabetes was associated with poorer survival after acute GvHD.Peer reviewe

Allogeneic hematopoietic cell transplantation in patients with CALR-mutated myelofibrosis:a study of the Chronic Malignancies Working Party of EBMT

Allogeneic hematopoietic cell transplantation (allo-HCT) is curative for myelofibrosis (MF) but assessing risk-benefit in individual patients is challenging. This complexity is amplified in CALR-mutated MF patients, as they live longer with conventional treatments compared to other molecular subtypes. We analyzed outcomes of 346 CALR-mutated MF patients who underwent allo-HCT in 123 EBMT centers between 2005 and 2019. After a median follow-up of 40 months, the estimated overall survival (OS) rates at 1, 3, and 5 years were 81%, 71%, and 63%, respectively. Patients receiving busulfan-containing regimens achieved a 5-year OS rate of 71%. Non-relapse mortality (NRM) at 1, 3, and 5 years was 16%, 22%, and 26%, respectively, while the incidence of relapse/progression was 11%, 15%, and 17%, respectively. Multivariate analysis showed that older age correlated with worse OS, while primary MF and HLA mismatched transplants had a near-to-significant trend to decreased OS. Comparative analysis between CALR- and JAK2-mutated MF patients adjusting for confounding factors revealed better OS, lower NRM, lower relapse, and improved graft-versus-host disease-free and relapse-free survival (GRFS) in CALR-mutated patients. These findings confirm the improved prognosis associated with CALR mutation in allo-HCT and support molecular profiling in prognostic scoring systems to predict OS after transplantation in MF.</p