Modelling of transport processes in concrete exposed to elevated temperatures – An alternative formulation for sorption isotherms

There is a significant need to understand, analyse and assess moisture transport in cementitious materials exposed to elevated temperatures in order to confidently predict the behaviour and ultimately the development of damage in safety critical applications such as nuclear reactor vessels, structures exposed to fire and well bore grouts. In view of this need a rigorous and robust formulation to describe water retention curves (sorption isotherms) as a function of temperature based on the evolution of physical parameters is presented. The model formulation is successfully validated against independent sets of experimental data up to temperatures of 80 °C. It is then further validated under isothermal drying conditions and then high temperature conditions through the numerical reproduction of laboratory experiments following implementation in a fully coupled hygro-thermo-mechanical finite element model. The new formulation is found to work well under a variety of conditions in a variety of cementitious material types

Concrete at high temperatures: hygro-thermo-mechanical degradation of concrete

The main aim of the presented work is the development of a reliable and coherent solution approach to investigate thermo-hygro-mechanical behaviour of concrete, especially under severe heating conditions. The work focuses on the development and extension of an existing analytical, numerical and constitutive model developed at the University of Glasgow. This is then used as a predictive modelling tool to investigate the response of concrete structures subject to combined thermo-mechanical loads. The thesis focuses initially on the coupled heat and mass transport model. A novel alternative formulation for sorption isotherms, that is applicable to both normal and high strength concrete, is developed. Furthermore, the effect of the slip flow effect is included and several state equations, including relative permeability and saturation vapour pressure, are adopted. Additionally, the effect of polypropylene fibres as a spalling prevention technique is modelled via a modification of the intrinsic permeability formulation. The transport model is further coupled with a damage-based mechanical model for concrete. The fully coupled thermo-hygro-mechanical model is presented through validation and verification problems and case studies. The model is implemented in a finite element formulation and behaves in a robust manner. The predictions of moisture state for the benchmark problems of drying and heating compare well with experimental results. Classical behaviour associated with heated concrete, such as moisture clog, gas pressure build-up, etc. are all captured by the presented model. The thesis concludes by considering the analysis of prestressed concrete pressure vessel

Natural History of Nonalcoholic Fatty Liver Disease: Implications for Clinical Practice and an Individualized Approach

Nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disease worldwide, associated with epidemics of overweight and resulting metabolic syndrome (MetS). Around 20–30% of patients with NAFLD develop progressive liver fibrosis, which is the most important predictor of liver-related and overall morbidity and mortality. In contrast to classical understanding, no significant association has been demonstrated between the inflammatory component of NAFLD, i.e., nonalcoholic steatohepatitis (NASH), and the adverse clinical outcomes. Older age (>50 years) and presence of type 2 diabetes mellitus, in addition to some genetic variants, are most consistently reported indicators of increased risk of having liver fibrosis. However, critical driving force for the progression of fibrosis and risk factors for this have still not been fully elucidated. Apart from the genetic profile, gut dysbiosis, weight gain, worsening of insulin resistance, and worsening of liver steatosis represent candidate factors associated with unfavourable development of liver disease. Cardiovascular events, extrahepatic malignancies, and liver-related deaths are the leading causes of mortality in NAFLD. As patients with advanced fibrosis are under highest risk of adverse clinical outcomes, efforts should be made to recognize individuals under risk and rule out the presence of this stage of fibrosis, preferably by using simple noninvasive tools. This process should start at the primary care level by using validated biochemical tests, followed by direct serum tests for fibrosis or elastography in the remaining patients. Patients with advanced fibrosis should be referred to hepatologists for aggressive lifestyle modification and correction of the components of MetS, and cirrhotic patients should be screened for hepatocellular carcinoma and oesophageal varices

Helping veterans achieve work: A Veterans Health Administration nationwide survey examining effective job development practices in the community.

Objective: Veterans Health Administration vocational services assist veterans with mental illness to acquire jobs; one major component of these services is job development. The purpose of this study was to characterize the nature of effective job development practices and to examine perceptions and intensity of job development services. Method: A national mixed-methods online survey of 233 Veterans Health Administration vocational providers collected data regarding frequency of employer contacts, perceptions of job development ease/difficulty, and effective job development practices when dealing with employers. Qualitative responses elucidating effective practices were analyzed using content analysis. Results: Vocational providers had a modest number of job development employer contacts across 2 weeks (M = 11.0, SD = 10.6) and fewer were face-to-face (M = 7.6, SD = 8.4). Over 70% of participants perceived job development to be difficult. Six major themes emerged regarding effective job development practices with employers: using an employer-focused approach; utilizing a targeted marketing strategy; engaging in preparation and follow-up; going about the employer interaction with genuineness, resilience, and a strong interpersonal orientation; serving as an advocate for veterans and educator of employers; utilizing specific employer-tailored strategies, such as arranging a one-on-one meeting with a decision maker and touring the business, individualizing a prescripted sales pitch, connecting on a personal level, and engaging in ongoing communication to solidify the working relationship. Conclusions and implications for practice: Respondents highlight several potentially effective job development strategies; tools and resources may be developed around these strategies to bolster job development implementation and allow opportunities for fruitful employer interactions

An interacting spin flip model for one-dimensional proton conduction

A discrete asymmetric exclusion process (ASEP) is developed to model proton conduction along one-dimensional water wires. Each lattice site represents a water molecule that can be in only one of three states; protonated, left-pointing, and right-pointing. Only a right(left)-pointing water can accept a proton from its left(right). Results of asymptotic mean field analysis and Monte-Carlo simulations for the three-species, open boundary exclusion model are presented and compared. The mean field results for the steady-state proton current suggest a number of regimes analogous to the low and maximal current phases found in the single species ASEP [B. Derrida, Physics Reports, {\bf 301}, 65-83, (1998)]. We find that the mean field results are accurate (compared with lattice Monte-Carlo simulations) only in the certain regimes. Refinements and extensions including more elaborate forces and pore defects are also discussed.Comment: 13pp, 6 fig

Assessment of adipokines, adenine nucleotides and uric acid in the dynamics of coronary intervention

Introduction: The association of vaspin and visfatin, with a myocardial infarction is still not fully understood. Reduced levels of adenine nucleotides are hallmarks of chronic heart failure. There is little data concerning the relationship between these markers and their changes over time. Material/Methods: The concentration of adenine nucleotides, vaspin and visfatinwere assessed in 41 consecutive patients with acute myocardial infarction one before (day I) and four days after (day IV) percutaneous coronary intervention (PCI) and a control group. Results: Visfatin concentrations were higher before and after PCI vs. control (visfatin I: median 25.55, 20.12 - 30.69 ng/ml; visfatin IV: median 20.79, 16.89 - 25.61 ng/ml vs. control: median 14.94, 10.66 - 25.25 ng/ml; p < 0.0001). Vaspin concentrations were lower before and after PCI vs. control (vaspin I: median 0.18, 0.11 - 0.44 ng/ml; vaspin IV: median 0.24, 0.15 - 0.58 ng/ml vs. control: median 1.303, 1.13 - 2.26 ng/ml, p < 0.00001). Concentrations of visfatin, day I, correlated well to vaspin concentrations (r2 = 0.201, p = 0.011). ATP levels were significantly lower in patients vs. controls (day I: p = 0.00012; day IV: p = 0.0001). Conclusions: Changes in the analyzed visfatin and vaspin concentrations can be used as potential MI markers. Visfatin serum concentration may be considered a potential marker to differentiate MI over time

Asymmetric exclusion process with next-nearest-neighbor interaction: some comments on traffic flow and a nonequilibrium reentrance transition

We study the steady-state behavior of a driven non-equilibrium lattice gas of hard-core particles with next-nearest-neighbor interaction. We calculate the exact stationary distribution of the periodic system and for a particular line in the phase diagram of the system with open boundaries where particles can enter and leave the system. For repulsive interactions the dynamics can be interpreted as a two-speed model for traffic flow. The exact stationary distribution of the periodic continuous-time system turns out to coincide with that of the asymmetric exclusion process (ASEP) with discrete-time parallel update. However, unlike in the (single-speed) ASEP, the exact flow diagram for the two-speed model resembles in some important features the flow diagram of real traffic. The stationary phase diagram of the open system obtained from Monte Carlo simulations can be understood in terms of a shock moving through the system and an overfeeding effect at the boundaries, thus confirming theoretical predictions of a recently developed general theory of boundary-induced phase transitions. In the case of attractive interaction we observe an unexpected reentrance transition due to boundary effects.Comment: 12 pages, Revtex, 7 figure

All aboard! Earth system investigations with the CH2O-CHOO TRAIN v1.0

Models of the carbon cycle and climate on geologic (&gt;104-year) timescales have improved tremendously in the last 50 years due to parallel advances in our understanding of the Earth system and the increase in computing power to simulate its key processes. Still, balancing the Earth system's complexity with a model's computational expense is a primary challenge in model development. Simulations spanning hundreds of thousands of years or more generally require a reduction in the complexity of the climate system, omitting features such as radiative feedbacks, shifts in atmospheric circulation, and the expansion and decay of ice sheets, which can have profound effects on the long-term carbon cycle. Here, we present a model for climate and the long-term carbon cycle that captures many fundamental features of global climate while retaining the computational efficiency needed to simulate millions of years of time. The Carbon–H2O Coupled HydrOlOgical model with Terrestrial Runoff And INsolation, or CH2O-CHOO TRAIN, couples a one-dimensional (latitudinal) moist static energy balance model of climate with a model for rock weathering and the long-term carbon cycle. The CH2O-CHOO TRAIN is capable of running million-year-long simulations in about 30 min on a laptop PC. The key advantages of this framework are (1) it simulates fundamental climate forcings and feedbacks; (2) it accounts for geographic configuration; and (3) it is flexible, equipped to easily add features, change the strength of feedbacks, and prescribe conditions that are often hard-coded or emergent properties of more complex models, such as climate sensitivity and the strength of meridional heat transport. We show how climate variables governing temperature and the water cycle can impact long-term carbon cycling and climate, and we discuss how the magnitude and direction of this impact can depend on boundary conditions like continental geography. This paper outlines the model equations, presents a sensitivity analysis of the climate responses to varied climatic and carbon cycle perturbations, and discusses potential applications and next stops for the CH2O-CHOO TRAIN.</p

Single-File Diffusion of Atomic and Colloidal Systems: Asymptotic Laws

In this work we present a general derivation of the non-Fickian behavior for the self-diffusion of identically interacting particle systems with excluded mutual passage. We show that the conditional probability distribution of finding a particle at position $x_{t}$ after time $t$, when the particle was located at $x_{0}$ at $t=0$, follows a Gaussian distribution in the long-time limit, with variance $2W(t)\sim t^{1/2}$ for overdamped systems and with variance $2W(t)\sim t$ for classical systems. The asymptotic behavior of the mean-squared displacement, $W(t)$, is shown to be independent of the nature of interactions for homogeneous systems in the fluid state. Moreover, the long-time behavior of self-diffusion is determined by short-time and large scale collective density fluctuations.Comment: 4 page