Ultrafast spatio-temporal dynamics of terahertz generation by ionizing two-color femtosecond pulses in gases

We present a combined theoretical and experimental study of spatio-temporal propagation effects in terahertz (THz) generation in gases using two-color ionizing laser pulses. The observed strong broadening of the THz spectra with increasing gas pressure reveals the prominent role of spatio-temporal reshaping and of a plasma-induced blue-shift of the pump pulses in the generation process. Results obtained from (3+1)-dimensional simulations are in good agreement with experimental findings and clarify the mechanisms responsible for THz emission

Vortex ring refraction at large Froude numbers

We have experimentally studied the impact of an initially planar axisymmetric vortex ring, incident at an oblique angle, upon a gravity-induced interface separating two fluids of differing densities. After impact, the vortex ring was found to exhibit a variety of subsequent trajectories, which we organize according to both the incidence angle, $\theta_i$, and the interface strength, defined as the ratio of the Atwood and Froude numbers, $A/F$. For grazing incidence angles ($\theta_i \gtrsim 70$ deg.) vortices either penetrate or reflect from the interface, depending on whether the interface is weak or strong. In some cases, reflected vortices execute damped oscillations before finally disintegrating. For smaller incidence angles ($\theta_i \lesssim 70$ deg.) vortices penetrate the interface. When there is a strong interface, these vortices are observed to curve back up toward the interface. When there is a weak interface, these vortices are observed to refract downward, away from the interface. The critical interface strength below which vortex ring refraction is observed is given by $\log_{10}{(A/F)}= -2.38 \pm 0.05$.Comment: 26 pages, 11 figures; Submitted to Physical Review

Community as resource: crowdsourcing transcription of an historic newspaper.

Like many cultural heritage institutions, the Archives and Special Collections at the University of Louisville faces the dichotomy of material abundance and budgetary scarcity. Driven by the desire to make historical primary sources accessible online, this organization harnessed the power of the public to transcribe the Louisville Leader, an historic African American newspaper. The first sections of this article define crowdsourcing and describe how it was implemented at the University of Louisville, including the tools adopted and the process used. The latter sections outline the marketing strategy, the public response, and lessons learned from this ongoing project

Overcoming legacy processing in photographic collections through collaboration and digital technologies.

In the 1960s, a Louisville photography studio began donating its negatives, prints, and invoices to the University of Louisville Photographic Archives. The Caufield & Shook Collection remains a significant primary source for local history and a prime candidate for digitization. Unfortunately, on its receipt non-archivists processed the collection with little documentation of original order or organizational decision making. Additionally, workflow choices were determined largely by the desire to maximize student labor. In 2017, the Digital Initiatives Librarian worked with in-house application developers and archives staff to create a workflow that has significantly sped up the process of making this valuable photographic collection accessible online. This article describes how archivists recovered from the poor processing decisions, used technology to enhance the digitization workflow, and developed a list of best practices for future processing and digitization of large photographic collections

Pluto: A Monte Carlo Simulation Tool for Hadronic Physics

Pluto is a Monte-Carlo event generator designed for hadronic interactions from Pion production threshold to intermediate energies of a few GeV per nucleon, as well as for studies of heavy ion reactions. This report gives an overview of the design of the package, the included models and the user interface.Comment: XI International Workshop on Advanced Computing and Analysis Techniques in Physics Research, April 23-27 2007, Amsterdam, the Netherland

Stellar Archaeology in the Galactic halo with the Ultra-Faint Dwarfs: VI. Ursa Major II

We present a B, V color-magnitude diagram (CMD) of the Milky Way dwarf satellite Ursa Major II (UMa II), spanning the magnitude range from V ~ 15 to V ~ 23.5 mag and extending over a 18 {\times} 18 arcmin2 area centered on the galaxy. Our photometry goes down to about 2 magnitudes below the galaxy's main sequence turn-off, that we detected at V ~ 21.5 mag. We have discovered a bona-fide RR Lyrae variable star in UMa II, which we use to estimate a conservative dereddened distance modulus for the galaxy of (m-M)0 = 17.70{\pm}0.04{\pm}0.12 mag, where the first error accounts for the uncertainties of the calibrated photometry, and the second reflects our lack of information on the metallicity of the star. The corresponding distance to UMa II is 34.7 {\pm} 0.6 ({\pm} 2.0) kpc. Our photometry shows evidence of a spread in the galaxy subgiant branch, compatible with a spread in metal abundance in the range between Z=0.0001 and Z=0.001. Based on our estimate of the distance, a comparison of the fiducial lines of the Galactic globular clusters (GCs) M68 and M5 ([Fe/H]=-2.27 {\pm} 0.04 dex and -1.33 {\pm} 0.02 dex, respectively), with the position on the CMD of spectroscopically confirmed galaxy members, may suggest the existence of stellar populations of different metal abundance/age in the central region of UMa II.Comment: To appear in Ap

The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse

The risk of relapsing into depression after stopping antidepressants is high, but no established predictors exist. Resting-state functional magnetic resonance imaging (rsfMRI) measures may help predict relapse and identify the mechanisms by which relapses occur. rsfMRI data were acquired from healthy controls and from patients with remitted major depressive disorder on antidepressants. Patients were assessed a second time either before or after discontinuation of the antidepressant, and followed up for six months to assess relapse. A seed-based functional connectivity analysis was conducted focusing on the left subgenual anterior cingulate cortex and left posterior cingulate cortex. Seeds in the amygdala and dorsolateral prefrontal cortex were explored. 44 healthy controls (age: 33.8 (10.5), 73% female) and 84 patients (age: 34.23 (10.8), 80% female) were included in the analysis. 29 patients went on to relapse and 38 remained well. The seed-based analysis showed that discontinuation resulted in an increased functional connectivity between the right dorsolateral prefrontal cortex and the parietal cortex in non-relapsers. In an exploratory analysis, this functional connectivity predicted relapse risk with a balanced accuracy of 0.86. Further seed-based analyses, however, failed to reveal diferences in functional connectivity between patients and controls, between relapsers and non-relapsers before discontinuation and changes due to discontinuation independent of relapse. In conclusion, changes in the connectivity between the dorsolateral prefrontal cortex and the posterior default mode network were associated with and predictive of relapse after open-label antidepressant discontinuation. This fnding requires replication in a larger dataset

The Clinical and Pathological Profile of BRCA1 Gene Methylated Breast Cancer Women. A Meta-Analysis

Background: DNA aberrant hypermethylation is the major cause of transcriptional silencing of the breast cancer gene 1 (BRCA1) gene in sporadic breast cancer patients. The aim of the present meta-analysis was to analyze all available studies reporting clinical characteristics of BRCA1 gene hypermethylated breast cancer in women, and to pool the results to provide a unique clinical profile of this cancer population. Methods: On September 2020, a systematic literature search was performed. Data were retrieved from PubMed, MEDLINE, and Scopus by searching the terms: “BRCA*” AND “methyl*” AND “breast”. All studies evaluating the association between BRCA1 methylation status and breast cancer patients’ clinicopathological features were considered for inclusion. Results: 465 studies were retrieved. Thirty (6.4%) studies including 3985 patients met all selection criteria. The pooled analysis data revealed a significant correlation between BRCA1 gene hypermethylation and advanced breast cancer disease stage (OR = 0.75: 95% CI: 0.58–0.97; p = 0.03, fixed effects model), lymph nodes involvement (OR = 1.22: 95% CI: 1.01–1.48; p = 0.04, fixed effects model), and pre-menopausal status (OR = 1.34: 95% CI: 1.08–1.66; p = 0.008, fixed effects model). No association could be found between BRCA1 hypermethylation and tumor histology (OR = 0.78: 95% CI: 0.59–1.03; p = 0.08, fixed effects model), tumor grading (OR = 0.78: 95% CI: 0.46–1.32; p = 0.36, fixed effects model), and breast cancer molecular classification (OR = 1.59: 95% CI: 0.68–3.72; p = 0.29, random effects model). Conclusions: hypermethylation of the BRCA1 gene significantly correlates with advanced breast cancer disease, lymph nodes involvement, and pre-menopausal cancer onset