Less bleeding by omitting aspirin in non-ST-segment elevation acute coronary syndrome patients: rationale and design of the LEGACY study

BackgroundEarly aspirin withdrawal, also known as P2Y12-inhibitor monotherapy, following percutaneous coronary intervention (PCI) for non-ST-segment elevation acute coronary syndrome (NSTE-ACS) can reduce bleeding without a trade-off in efficacy. Still the average daily bleeding risk is highest during the first months and it remains unclear if aspirin can be omitted immediately following PCI.MethodsThe LEGACY study is an open-label, multicenter randomized controlled trial evaluating the safety and efficacy of immediate P2Y12-inhibitor monotherapy versus dual antiplatelet therapy (DAPT) for 12 months in 3,090 patients. Patients are randomized immediately following successful PCI for NSTE-ACS to 75-100 mg aspirin once daily versus no aspirin. The primary hypothesis is that immediately omitting aspirin is superior to DAPT with respect to major or minor bleeding defined as Bleeding Academic Research Consortium type 2, 3, or 5 bleeding, while maintaining noninferiority for the composite of all-cause mortality, myocardial infarction and stroke compared to DAPT.ConclusionsThe LEGACY study is the first randomized study that is specifically designed to evaluate the impact of immediately omitting aspirin, and thus treating patients with P2Y12-inhibitor monotherapy, as compared to DAPT for 12 months on bleeding and ischemic events within 12 months following PCI for NSTE-ACS.Cardiolog

Die deutschen Tochtergesellschaften in der Tuerkei und ihre Wachstumschancen und Hemmungsprobleme unter der Beruecksichtigung der Anwendung des Fremdkapitalgesetzes

Bonn, Univ., Diss., 1987Available from Bibliothek des Instituts fuer Weltwirtschaft, ZBW, Duesternbrook Weg 120, D-24105 Kiel A 171113 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

ON THE EXISTENCE AND UNIQUENESS OF THE SOLUTION OF AN OPTIMAL CONTROL PROBLEM FOR SCHRODINGER EQUATION

WOS: 000443699200007In this paper, an optimal control problem for Schrodinger equation with complex coefficient which contains gradient is examined. A theorem is given that states the existence and uniqueness of the solution of the initial-boundary value problem for Schrodinger equation. Then for the solution of the optimal control problem, two different cases are investigated. Firstly, it is shown that the optimal control problem has a unique solution for alpha > 0 on a dense subset G on the space H which contains the measurable square integrable functions on (0, l) and secondly the optimal control problem has at least one solution for any alpha >= 0 on the space H.National Thesis Center of The Council of Higher Education (YOK) of Turkey [294880]This study has been formed out of Gokce Dilek Kucuk's master's thesis which is numbered as 294880 at National Thesis Center of The Council of Higher Education (YOK) of Turkey

High Resolution Coude Echelle Spectroscopy of IX Per

High resolution (R=45033) Coude - Echelle spectra of IX Per has been obtained at TUBITAK National Observatory (TUG) of Turkey. IX Per has been known to be a single lined (SBI) spectroscopic binary having chromospheric activity. However, analyzed spectra of IX Per by KOREL disentangling method indicated that the system is a double lined (SB2) spectroscopic binary. Weaker lines from the secondary arc discovered on the decomposed spectra. A preliminary orbit indicates that the mass ratio of the system is 0.64. The light contribution of the secondary is tip to 10% in investigated spectral region. Circular orbit is sufficient to explain radial velocity variations