Surgical Treatment for Skeletal Metastases From Soft Tissue Sarcomas: Experience With 23 Lesions in 20 Patients

Purpose. This paper reports the procedures and the clinical results of a series of surgical treatments for skeletal metastases from soft tissue sarcomas

Expression of Smooth Muscle Calponin in Synovial Sarcoma

Purpose. Histogenesis of synovial sarcoma remains controversial and reliable molecular markers for diagnosis are necessary. Expression of basic calponin, a smooth muscle differentiation-specific actin-binding protein, was studied in synovial sarcoma

Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas: Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study

AbstractBackgroundThe radiographic evaluation of the response to preoperative chemotherapy for bone and soft tissue sarcomas is based mostly on the change in primary tumor size before and after chemotherapy, as is done for many solid cancers. Its prognostic correlation, however, has hardly been validated.MethodsWe conducted a retrospective validation study of the Japanese Orthopaedic Association (JOA) radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas as a JOA Committee on Musculoskeletal Tumors cooperative study. A total of 125 consecutive patients with high-grade bone (n = 77) and soft tissue (n = 48) sarcomas treated with neoadjuvant chemotherapy and definitive surgery in 25 tertiary referral hospitals were selected for the study. We investigated the correlation between the tumor size-based radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas provided by the JOA Committee on Musculoskeletal Tumors (hereafter called the JOA criteria) and the patients’ overall survival using the Kaplan-Meier method and the log-rank test.ResultsThe JOA criteria correlated relatively well with survival for malignant bone tumors (mostly comprising osteosarcoma and Ewing’s sarcoma) but not for soft tissue sarcomas, suggesting that the tumor size-based radiographic evaluation criteria for the response to preoperative chemotherapy in patients with soft tissue sarcomas is invalid.ConclusionsThe JOA criteria, based on the change in primary tumor size, is valid for malignant bone tumors but invalid for soft tissue sarcomas. Other new evaluation modalities of the response to preoperative chemotherapy using innovative functional imaging techniques are needed for soft tissue sarcomas

ユルスナール ノ エレクトラ ボセイ ト セクシュアリティ ノ ハザマデ

Dans cette piece qui se base sur Electre d\u27Euripide de la tragedie grecque,nous trouvons quelques points de transformation assez particuliers par rapport aux autres adaptations precedentes. Par exemple,Yo urcenar met Electre au centre de l\u27histoire alors qu\u27Oreste son frere,heros dans la tragedie grecque,n\u27agit pas en heros dans cette piece; il n\u27execute pas son acte de justice. Ici c\u27est Electre seule qui etrangle sa mere de ses propres mains. Il existe dans cette adaptation une rivalite evidente et un contraste saisissant entre la mere et la file; l\u27une montre son amour maternel et son bonheur feminin et l\u27autre refuse d\u27avoir des enfants et se laisse vivre hors de la sexualite. Sa jalousie et sa haine envers sa mere la conduisent a la matricide. De plus,pour affirmer son identite,Oreste,garcon faible qui s\u27 appuie sur sa soeur,tue son propre pere Egiste,bien que celui-ci lui montre beaucoup d\u27affection. Ainsi,apres leurs matricide et patricide,ces freres et soeurs se dessinent. avec leur ami homosexuel Pylades,un avenir incertain,ambigu et sterile. Cela nous fait penser a la situation de l\u27auteur a l\u27epoque. Ayant perdu sa mere a sa naissance,elle n\u27a pas connu le veritable amour maternel. Lors de son adaptation de cette piece,ayant quitte son pays natal pour fuir la guerre,Yourcenar a decide de vivre aux Etats-Unis avec Grace Frick qui est devenue plus tard sa partenaire de vie. Cette piece de la tragedie moderne reflete les difficultes diverses concernant la vie et les valeurs de cette femme ecrivain mais elles ne sont pas seulement celles de Yourcenar mais aussi est-ce que ce ne sont pas celles deslecteurs et lectrices actuels et futurs egalement