2,954 research outputs found
Djelotvorna primjena statističke kontrole procesa (SKP) rezanja uzdužno namotanih limova na škarama
This paper deals with the effective application of SPC on the lengthwise tonsure rolled plates process on double side scissors. After explanation of the SPC fundamentals, goals and mistakes during the SPC implementation, the methodical framework for the effective SPC application is defined. In the next part of the paper the description of practical application of SPC and its analysis from the point of view of this framework is accomplished.Ovaj članak opisuje djelotvornu primjenu SKP na proces rezanja uzdužno namotanih limova na škarama s dvostrukom oštricom. Nakon objašnjenja osnova SKP, ciljeva i grešaka kod primjene SKP, metodski okvir za efektivnu primjenu SKP je defi niran. Sljedi opis praktične primjene SKP i njegove analiza sa stajališta da je opisani okvir primjene kompletan
Determination of the phase diagram of the electron doped superconductor Ba(FeCo)As
Systematic measurements of the resistivity, heat capacity, susceptibility and
Hall coefficient are presented for single crystal samples of the electron-doped
superconductor Ba(FeCo)As. These data delineate an
phase diagram in which the single magnetic/structural phase transition that is
observed for undoped BaFeAs at 134 K apparently splits into two
distinct phase transitions, both of which are rapidly suppressed with
increasing Co concentration. Superconductivity emerges for Co concentrations
above , and appears to coexist with the broken symmetry state for
an appreciable range of doping, up to . The optimal
superconducting transition temperature appears to coincide with the Co
concentration at which the magnetic/structural phase transitions are totally
suppressed, at least within the resolution provided by the finite step size
between crystals prepared with different doping levels. Superconductivity is
observed for a further range of Co concentrations, before being completely
suppressed for and above. The form of this phase diagram
is suggestive of an association between superconductivity and a quantum
critical point arising from suppression of the magnetic and/or structural phase
transitions
Quantum oscillations in the parent pnictide BaFeAs : itinerant electrons in the reconstructed state
We report quantum oscillation measurements that enable the direct observation
of the Fermi surface of the low temperature ground state of \ba122. From these
measurements we characterize the low energy excitations, revealing that the
Fermi surface is reconstructed in the antiferromagnetic state, but leaving
itinerant electrons in its wake. The present measurements are consistent with a
conventional band folding picture of the antiferromagnetic ground state,
placing important limits on the topology and size of the Fermi surface.Comment: 5 pages, 3 figure
Consequences of the pathogenic T9176C mutation of human mitochondrial DNA on yeast mitochondrial ATP synthase
Several human neurological disorders have been associated with various mutations affecting mitochondrial enzymes involved in cellular ATP production. One of these mutations, T9176C in the mitochondrial DNA (mtDNA), changes a highly conserved leucine residue into proline at position 217 of the mitochondrially encoded Atp6p (or a) subunit of the F1FO-ATP synthase. The consequences of this mutation on the mitochondrial ATP synthase are still poorly defined. To gain insight into the primary pathogenic mechanisms induced by T9176C, we have investigated the consequences of this mutation on the ATP synthase of yeast where Atp6p is also encoded by the mtDNA. In vitro, yeast atp6-T9176C mitochondria showed a 30% decrease in the rate of ATP synthesis. When forcing the F1FO complex to work in the reverse mode, i.e. F1-catalyzed hydrolysis of ATP coupled to proton transport out of the mitochondrial matrix, the mutant showed a normal proton-pumping activity and this activity was fully sensitive to oligomycin, an inhibitor of the ATP synthase proton channel. However, under conditions of maximal ATP hydrolytic activity, using non-osmotically protected mitochondria, the mutant ATPase activity was less efficiently inhibited by oligomycin (60% inhibition versus 85% for the wild type control). Blue Native Polyacrylamide Gel Electrophoresis analyses revealed that atp6-T9176C yeast accumulated rather good levels of fully assembled ATP synthase complexes. However, a number of sub-complexes (F1, Atp9p-ring, unassembled alpha-F1 subunits) could be detected as well, presumably because of a decreased stability of Atp6p within the ATP synthase. Although the oxidative phosphorylation capacity was reduced in atp6-T9176C yeast, the number of ATP molecules synthesized per electron transferred to oxygen was similar compared with wild type yeast. It can therefore be inferred that the coupling efficiency within the ATP synthase was mostly unaffected and that the T9176C mutation did not increase the proton permeability of the mitochondrial inner membrane
The small GTPase Arf1 regulates ATP synthesis and mitochondria homeostasis by modulating fatty acid metabolism
Lipid mobilization through fatty acid β-oxidation is a central process essential for energy 36 production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome from where β-oxidation products enter mitochondria and fuel the TCA cycle. Little is known about the physical and metabolic cooperation between these organelles. We found that expression of fatty acid transporters and of the rate-limiting enzyme involved in β-oxidation are decreased in cells expressing a hyperactive mutant of the small GTPase Arf1, leading to an accumulation of fatty acids in lipid droplets. As a consequence, mitochondria became fragmented and ATP synthesis decreased. Genetic and pharmacological depletion of fatty acids phenocopied the arf1 mutant mitochondrial phenotype. Although β-oxidation occurs mainly in mitochondria in mammals, Arf1's role in fatty acid metabolism is conserved. Together, our results indicate that Arf1 integrates metabolism into energy production by regulating fatty acid storage and utilization, and presumably organelle contact-sites
Specific Heat Discontinuity, deltaC, at Tc in BaFe2(As0.7P0.3)2 - Consistent with Unconventional Superconductivity
We report the specific heat discontinuity, deltaC/Tc, at Tc = 28.2 K of a
collage of single crystals of BaFe2(As0.7P0.3)2 and compare the measured value
of 38.5 mJ/molK**2 with other iron pnictide and iron chalcogenide (FePn/Ch)
superconductors. This value agrees well with the trend established by Bud'ko,
Ni and Canfield who found that deltaC/Tc ~ a*Tc**2 for 14 examples of doped
Ba1-xKxFe2As2 and BaFe2-xTMxAs2, where the transition metal TM=Co and Ni. We
extend their analysis to include all the FePn/Ch superconductors for which
deltaC/Tc is currently known and find deltaC/Tc ~ a*Tc**1.9 and a=0.083
mJ/molK**4. A comparison with the elemental superconductors with Tc>1 K and
with A-15 superconductors shows that, contrary to the FePn/Ch superconductors,
electron-phonon-coupled conventional superconductors exhibit a significantly
different dependence of deltaC on Tc, namely deltaC/Tc ~ Tc**0.9. However
deltaC/gamma*Tc appears to be comparable in all three classes (FePn/Ch,
elemental and A-15) of superconductors with, e. g., deltaC/gamma*Tc=2.4 for
BaFe2(As0.7P0.3)2. A discussion of the possible implications of these
phenomenological comparisons for the unconventional superconductivity believed
to exist in the FePn/Ch is given.Comment: some disagreement in reference and footnote numbering with the
published versio
Improved performance of the LHCb Outer Tracker in LHC Run 2
The LHCb Outer Tracker is a gaseous detector covering an area of with 12 double layers of straw tubes. The performance of the detector is
presented based on data of the LHC Run 2 running period from 2015 and 2016.
Occupancies and operational experience for data collected in , pPb and
PbPb collisions are described. An updated study of the ageing effects is
presented showing no signs of gain deterioration or other radiation damage
effects. In addition several improvements with respect to LHC Run 1 data taking
are introduced. A novel real-time calibration of the time-alignment of the
detector and the alignment of the single monolayers composing detector modules
are presented, improving the drift-time and position resolution of the detector
by 20\%. Finally, a potential use of the improved resolution for the timing of
charged tracks is described, showing the possibility to identify low-momentum
hadrons with their time-of-flight.Comment: 29 pages, 20 figures, minor changes to match the published versio
Simultaneous intra/extravascular administration of antiproliferative agents as a new strategy to inhibit restenosis: The peak of reactive cell proliferation as a hallmark for the duration of the treatment
BACKGROUND: Strictly intravascular approaches for the treatment of postangioplasty restenosis are effective in the intima and the inner parts of the media but may be insufficient to control redundant pathways in the more outer parts of the media and the adventitia. An inverse situation may occur subsequently to a strictly extravascular approach, like the recently suggested pericardial approach in pigs. We hypothesized that simultaneous intra/extravascular administration of anti-restenotic agents inhibits restenosis by blocking all stimulatory pathways in the entire arterial wall. METHODS: Fresh hearts of 25 domestic pigs were obtained from a local slaughterhouse. Left anterior descending coronary arteries (LAD) were harvested, cut into cylindric 5 mm segments, and cultured as ex vivo porcine organ cultures (POCs). After 9 bar ballooning simultaneous intra/extravascular administration of high dose diltiazem (50 μg/mL) was carried out for a period of 1, 2, 3, 4, 5, 6, and 7 days. At day 7 and 28 proliferative activity (BrdU), neointimal thickening, and staining against smooth muscle α-actin and vWF was analysed. RESULTS: 7 days after ballooning administration of diltiazem for 4, 5, 6, and 7 days inhibited reactive cell proliferation by more than 50% (n.s.) as compared to control, 28 days after ballooning administration for 6 and 7 days inhibited neointimal thickening by more than 75% (p < 0.05). Simultaneous intra/extravascular administration of high dose diltiazem did not affect the expression of vWF in endothelial cells or smooth muscle α-actin in smooth muscle cells. CONCLUSIONS: Simultaneous intra/extravascular administration of high dose diltiazem (50 μg/mL) has to be maintained for at least 6 days to achieve a significant inhibition of neointimal thickening. The data demonstrate the importance of the maximal reactive cell proliferation (= day 7 in the POC-model) for the calculation of the duration of the treatment period
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