Medication Therapy Management: The Perspective of the Case Manager

What is the case manager’s perspective on medication therapy management? The study consisted of 3 focus groups consisting of mental health case managers who work with clients in the community within the St. Paul and Minneapolis, Minnesota. This study analyzed how case managers engage with their client; more specifically, the perceived importance of engagement and effectiveness of client engagement was explored. This research also examined what barriers case managers face in engaging with their clients and how these barriers affect a client to be medication compliant. Finally, this research attempted to obtain data on the case manager’s attitude of the importance of medication as a form of treatment for clients. This study used a qualitative approach to interviewing case managers in agencies chosen from a convenience sample. Narrative information from interviews was transcribed and subjected to a content analysis to inductively explore themes from the sample

Medication Therapy Management: The Perspective of the Case Manager

What is the case manager’s perspective on medication therapy management? The study consisted of 3 focus groups consisting of mental health case managers who work with clients in the community within the St. Paul and Minneapolis, Minnesota. This study analyzed how case managers engage with their client; more specifically, the perceived importance of engagement and effectiveness of client engagement was explored. This research also examined what barriers case managers face in engaging with their clients and how these barriers affect a client to be medication compliant. Finally, this research attempted to obtain data on the case manager’s attitude of the importance of medication as a form of treatment for clients. This study used a qualitative approach to interviewing case managers in agencies chosen from a convenience sample. Narrative information from interviews was transcribed and subjected to a content analysis to inductively explore themes from the sample

Preliminary characterisation of two early meiotic wheat proteins after identification through 2D gel electrophoresis proteomics

Various genetic-based approaches including mutant population screens, microarray analyses, cloning and transgenesis have broadened our knowledge of gene function during meiosis in plants. Nonetheless, these genetic tools are not without inherent limitations. One alternative approach to studying plant meiosis, especially in polyploids such as Triticum aestivum L. (bread wheat), is proteomics. However, protein-based approaches using proteomics have seldom been described, with only two attempts at studying early plant meiosis reported. Here, we report the investigation of early bread wheat meiosis using proteomics. Five differentially expressed protein spots were identified using 2D gel electrophoresis (2DGE) on protein extracts from four pooled stages of meiosis and three genotypes (Chinese Spring wild-type, ph1b and ph2a wheat mutant lines). Tandem mass spectrometry (MS/MS) identification of peptides from these protein spots led to the isolation and characterisation of the full-length clones of a wheat Speckle-typePOZprotein, an SF21-like protein and HSP70, and a partial coding sequence of a hexose transporter. Significantly, the putative functions of the Speckle-type POZ protein and HSP70 were confirmed using in vitro DNA binding assays. Through the use of a 2DGE proteomics approach, we show that proteomics is a viable alternative to genetic-based approaches when studying meiosis in wheat. More significantly, we report a potential role for a Speckle-type POZ protein and a HSP70 in chromosome pairing during the early stages of meiosis in bread wheat.Kelvin H.P. Khoo, Amanda J. Able, Timothy K. Chataway and Jason A. Abl