Different worlds of contention? Protest in Northwestern, Southern and Eastern Europe

Despite the voluminous literature on the ‘normalisation of protest’, the protest arena is seen as a bastion of left‐wing mobilisation. While citizens on the left readily turn to the streets, citizens on the right only settle for it as a ‘second best option’. However, most studies are based on aggregated cross‐national comparisons or only include Northwestern Europe. We contend the aggregate‐level perspective hides different dynamics of protest across Europe. Based on individual‐level data from the European Social Survey (2002–2016), we investigate the relationship between ideology and protest as a key component of the normalisation of protest. Using hierarchical logistic regression models, we show that while protest is becoming more common, citizens with different ideological views are not equal in their protest participation across the three European regions. Instead of a general left predominance, we find that in Eastern European countries, right‐wing citizens are more likely to protest than those on the left. In Northwestern and Southern European countries, we find the reverse relationship, left‐wing citizens are more likely to protest than their right‐wing counterparts. Lessons drawn from the protest experience in Northwestern Europe characterised by historical mobilisation by the New Left are of limited use for explaining the ideological composition of protest in the Southern and Eastern European countries. We identify historical and contemporary regime access as the mechanism underlying regional patterns: citizens with ideological views that were historically in opposition are more likely to protest. In terms of contemporary regime access, we find that partisanship enhances the effect of ideology, while ideological distance from the government has a different effect in the three regions. As protest gains in importance as a form of participation, the paper contributes to our understanding of regional divergence in the extent to which citizens with varying ideological views use this tool

Relationship between Telomere Length, TERT Genetic Variability and TERT, TP53, SP1, MYC Gene Co-Expression in the Clinicopathological Profile of Breast Cancer

The molecular mechanisms of telomerase reverse transcriptase (TERT) upregulation in breast cancer (BC) are complex. We compared genetic variability within TERT and telomere length with the clinical data of patients with BC. Additionally, we assessed the expression of the TERT, MYC, TP53 and SP1 genes in BC patients and in BC organoids (3D cell cultures obtained from breast cancer tissues). We observed the same correlation in the blood of BC patients and in BC organoids between the expression of TERT and TP53. Only in BC patients was a correlation found between the expression of the TERT and MYC genes and between TP53 and MYC. We found associations between TERT genotypes (rs2735940 and rs10069690) and TP53 expression and telomere length. BC patients with the TT genotype rs2735940 have a shorter telomere length, but patients with A allele rs10069690 have a longer telomere length. BC patients with a short allele VNTR-MNS16A showed higher expression of the SP1 and had a longer telomere. Our results bring new insight into the regulation of TERT, MYC, TP53 and SP1 gene expression related to TERT genetic variability and telomere length. Our study also showed for the first time a similar relationship in the expression of the above genes in BC patients and in BC organoids. These findings suggest that TERT genetic variability, expression and telomere length might be useful biomarkers for BC, but their prognostic value may vary depending on the clinical parameters of BC patients and tumor aggressiveness