Iodine Deficiency Disorder and Goitre among School Children in Sarawak -A Nationwide Study.

Iodine deficiency disorders (IDD), is one of the most important micronutrient deficiencies which has multiple adverse effects on growth and development. The aim of this study was to determine the prevalence of IDD among school children and to elucidate the distribution of iodized salt at household level in Sarawak, East Malaysia. This cross-sectional study was conducted among school children aged 8 to 10 years in 2008. A multi-stage probability proportionate to population size(PPS) cluster sampling method was used to obtain a representative state sample of 1200 school children. Spot urine samples were collected for the determination of urinary iodine concentration while the iodine content in salt was determined using field rapid test kits. The thyroid status was determined by palpation. Response rate was 92.0% (n=1104/1200). The prevalence of goitre among school children in Sarawak was 2.9% (5.2% in urban, 0.7% in rural). The median urinary iodine concentration (UIC) among the school children was 102.1 μg/L (IQR, 62.3-146.5 μg/L). Urban children had significantly higher median UIC of 109.3 μg/L (IQR, 72.4-159.0 μg/L) than their rural counterparts [91.9 μg/L (IQR, 55.7-140.2 μg/L)]. The salt samples tested by rapid test kit (RTK) showed only 46.0% of household salt contained iodine. The present study revealed that the population in Sarawak were of borderline iodine sufficient with mild IDD seen in rural areas. Hence, the state IDD control programmes need to encourage and advocate the consumption of iodized salt in order to eliminate IDD-related health problems in Sarawak

Factors associated with non-participation in a health screening programme and its barriers: findings from the community empowers the nation programme (KOSPEN), Malaysia 2016

Introduction The Ministry of Health, Malaysia had introduced the community based action programme (KOSPEN) to improve the early detection of non-communicable diseases (NCDs) in the population. This study aims to identify factors associated with non-participation in screening activities and its barriers. Methods This cross sectional study was conducted from May to June 2016 in KOSPEN localities. A total of 2354 adults aged 18 years and above were selected using a two-stage stratified cluster sampling design. The data were obtained through face-to-face interviews using validated questionnaires. Multiple logistic regression analysis was used to determine the sociodemographic factors associated with non-participation in health screening. Results Out of 2156 respondents interviewed (response rate of 91.6%), approximately 75% (n=1624) of the respondents did not participate in the KOSPEN health screening programme. Multivariable logistic regression analyses revealed that, males (aOR: 2.35, 95% CI 1.21, 4.55) and those working in private sector (aOR: 2.11, 95% CI 1.21, 3.67) were more likely to not participate in health screening. While, age, ethnicity, level of education, marital status and household income were not significantly associated with non-participation in health screening. The barrier for not participated were “did not know health screening was conducted in their localities” (39.3%) and had no time to attend the programme (18.2%). Conclusions The study findings are of public health concern as about three quarters of the respondents failed to participate in this programme because they didn’t know that there were health screening activities conducted in their localities beside the time constraint problems. Thus, KOSPEN health screening activities should be made known to the community especially males who are mostly working in the private sector

Navigating the path to construction 4.0: Policies, challenges, and strategies in Malaysian construction industry

Objective - This research introduces the Kaleidoscope Model, which offers a roadmap for policymakers to perform effective changes with the moderating effect of the challenges faced. Methodology - The study employs document analysis and semi-structured interviews for qualitative data through content analysis. Findings - Results highlight that Policy Adoption and Policy Implementation notably influence the evaluation of the effectiveness of the Construction 4.0 policy. It is found that the moderating effect (challenges) does not influence the adoption of the Construction 4.0 policy in the Malaysian construction industry. Novelty - The novelty of this research lies in its provision of a framework, namely the Kaleidoscope Model, designed to facilitate the assessment of the effectiveness of implementing the Construction 4.0 policy in Malaysia. This framework aids policymakers and construction stakeholders in better understanding how to embrace new technologies, ultimately contributing to the realization of policy goals and enhancing effectiveness and efficiency in the construction industry

Candidate genes linked to QTL regions associated with fatty acid composition in oil palm

© 2020, Institute of Molecular Biology, Slovak Academy of Sciences. The present study searched for candidate genes in five linkage groups (LGs) - T2, T3, OT4, OT6 and T9 hosting the QTLs associated with iodine value (IV) and fatty acid composition (FAC) in an oil palm interspecific hybrid population. Each of the five LGs was successfully anchored to its corresponding chromosomal segment where, a wider repertoire of candidate genes was identified. This study further revealed a total of 19 candidate genes and four transcription factors involved in biosynthesis of fatty acids, lipids (including triacylglycerol) and acetyl-CoA, glycosylation and degradation of fatty acids. Their possible involvement in regulating the levels of saturation are discussed. In addition, 22 candidate genes located outside the QTL intervals were also identified across the interspecific hybrid genome. A total of 92 SSR markers were developed to tag the presence of these candidate genes and 50 were successfully mapped onto their respective positions on the genome. The data obtained here complements the previous studies, and collectively, these QTL-linked candidate gene markers could help breeders in more precisely selecting palms with the desired FAC

Ant colony optimization for design of water distribution systems

During the last decade, evolutionary methods such as genetic algorithms have been used extensively for the optimal design and operation of water distribution systems. More recently, ant colony optimization algorithms ~ACOAs!, which are evolutionary methods based on the foraging behavior of ants, have been successfully applied to a number of benchmark combinatorial optimization problems. In this paper, a formulation is developed which enables ACOAs to be used for the optimal design of water distribution systems. This formulation is applied to two benchmark water distribution system optimization problems and the results are compared with those obtained using genetic algorithms ~GAs!. The findings of this study indicate that ACOAs are an attractive alternative to GAs for the optimal design of water distribution systems, as they outperformed GAs for the two case studies considered both in terms of computational efficiency and their ability to find near global optimal solutions.Holger R. Maier, Angus R. Simpson, Aaron C. Zecchin, Wai Kuan Foong, Kuang Yeow Phang, Hsin Yeow Seah and Chan Lim Ta

An assessment of risk of iodine deficiency among pregnant women in Sarawak, Malaysia

Previous findings from a state-wide Iodine Deficiency Disorders (IDD) study among pregnant women (PW) in Sarawak indicated that PW are at risk of IDD and further assessment is needed. This paper describes the methodology used in conducting this study for an assessment of risk of iodine deficiency among pregnant women in Sarawak, Malaysia. A total of 30 maternal child health care clinics (MCHCs) were selected using probability proportional to population size (PPS) sampling technique.  The PW sample size was calculated based on 95% confidence interval (CI), relative precision of 5%, design effect of 2, anticipated IDD prevalence of  65.0% and non-response rate of 20%. Thus, the total sample size required was 750 (25 respondents per selected MCHC). The WHO Expanded Programme on Immunization (EPI) surveys approach was used to randomly select the first respondent and subsequent respondents were chosen until the required number of PW was met. The required data were obtained through: face-to-face interviews (socio-demographic and food frequency questionnaire), clinical assessments (thyroid size, and hyper/hypothyroidism) and biochemical analysis (urine and blood serum). A total of 677 PW responded in the study with a response rate of 90.2%. Majority of the PW were at second gravida, aged 25-29 years old and of Malay ethnicity. The methodology used in this study was based on international guidelines which may provide state’s estimates. All the necessary steps were taken into consideration to ensure valid and reliable findings on current iodine status among PW

In silico characterization and expression profiling of the diacylglycerol acyltransferase gene family (DGAT1, DGAT2, DGAT3 and WS/DGAT) from oil palm, Elaeis guineensis

The diacylglycerol acyltransferases (DGAT) (diacylglycerol:acyl-CoA acyltransferase, EC 2.3.1.20) are a key group of enzymes that catalyse the final and usually the most important rate-limiting step of triacylglycerol biosynthesis in plants and other organisms. Genes encoding four distinct functional families of DGAT enzymes have been characterised in the genome of the African oil palm, Elaeis guineensis. The contrasting features of the various isoforms within the four families of DGAT genes, namely DGAT1, DGAT2, DGAT3 and WS/DGAT are presented both in the oil palm itself and, for comparative purposes, in 12 other oil crop or model/related plants, namely Arabidopsis thaliana, Brachypodium distachyon, Brassica napus, Elaeis oleifera, Glycine max, Gossypium hirsutum, Helianthus annuus, Musa acuminata, Oryza sativa, Phoenix dactylifera, Sorghum bicolor, and Zea mays. The oil palm genome contains respectively three, two, two and two distinctly expressed functional copies of the DGAT1, DGAT2, DGAT3 and WS/DGAT genes. Phylogenetic analyses of the four DGAT families showed that the E. guineensis genes tend to cluster with sequences from P. dactylifera and M. acuminata rather than with other members of the Commelinid monocots group, such as the Poales which include the major cereal crops such as rice and maize. Comparison of the predicted DGAT protein sequences with other animal and plant DGATs was consistent with the E. guineensis DGAT1 being ER located with its active site facing the lumen while DGAT2, although also ER located, had a predicted cytosol-facing active site. In contrast, DGAT3 and some (but not all) WS/DGAT in E. guineensis are predicted to be soluble, cytosolic enzymes. Evaluation of E. guineensis DGAT gene expression in different tissues and developmental stages suggests that the four DGAT groups have distinctive physiological roles and are particularly prominent in developmental processes relating to reproduction, such as flowering, and in fruit/seed formation especially in the mesocarp and endosperm tissues

Physical inactivity and its associated factors among adults in Malaysia : findings from National Health and Morbidity Survey (NHMS) 2019

Physical inactivity has been identified as the fourth leading risk factor for worldwide mortality with major implications towards general health. Monitoring the level of physical inactivity may reduce the burden of non-communicable diseases (NCDs) and their risk factors. This study aims to determine the prevalence of physical inactivity and its associated factors among adults aged 18 years and above in Malaysia. Data was obtained from the National Health and Morbidity Survey (NHMS) 2019. It was a cross-sectional, population-based survey which employed two- stage stratified random sampling design. A total of 10,356 out of 10,472 respondents were interviewed using a short version of International Physical Activity Questionnaire (IPAQ). Overall, the prevalence of physical inactivity among adults aged 18 years and above in Malaysia was 24.6% (95% CI: 23.2, 26.1). Results from multivariable logistic model showed that Chinese ethnicity (aOR 1.32; 95% CI: 1.04, 1.67), urban dwellers (aOR 1.30; 95% CI: 1.07, 1.57), those who were single (including widow, widower and divorcee) (aOR 1.36; 95% CI: 1.14, 1.61), students (aOR 2.10; 95% CI: 1.30, 3.40), higher household income earners (aOR 1.34; 95% CI: 1.07, 1.68) and those with hypercholesterolaemia (aOR 1.25; 95% CI: 1.03, 1.51) were significantly more likely to be physically inactive. Specific and appropriate intervention towards targeted group is in crucial need to increase the level of physical activity and to promote an active living towards an active and healthy Malaysia

Expression of fatty acid and triacylglycerol synthesis genes in interspecific hybrids of oil palm

© 2020, The Author(s). Evaluation of transcriptome data in combination with QTL information has been applied in many crops to study the expression of genes responsible for specific phenotypes. In oil palm, the mesocarp oil extracted from E. oleifera × E. guineensis interspecific hybrids is known to have lower palmitic acid (C16:0) content compared to pure African palms. The present study demonstrates the effectiveness of transcriptome data in revealing the expression profiles of genes in the fatty acid (FA) and triacylglycerol (TAG) biosynthesis processes in interspecific hybrids. The transcriptome assembly yielded 43,920 putative genes of which a large proportion were homologous to known genes in the public databases. Most of the genes encoding key enzymes involved in the FA and TAG synthesis pathways were identified. Of these, 27, including two candidate genes located within the QTL associated with C16:0 content, showed differential expression between developmental stages, populations and/or palms with contrasting C16:0 content. Further evaluation using quantitative real-time PCR revealed that differentially expressed patterns are generally consistent with those observed in the transcriptome data. Our results also suggest that different isoforms are likely to be responsible for some of the variation observed in FA composition of interspecific hybrids