Diffraction-limited near-IR imaging at Keck reveals asymmetric, time-variable nebula around carbon star CIT 6

We present multi-epoch, diffraction-limited images of the nebula around the carbon star CIT 6 at 2.2 microns and 3.1 microns from aperture masking on the Keck-I telescope. The near-IR nebula is resolved into two main components, an elongated, bright feature showing time-variable asymmetry and a fainter component about 60 milliarcseconds away with a cooler color temperature. These images were precisely registered (~35 milliarcseconds) with respect to recent visible images from the Hubble Space Telescope (Trammell et al. 2000), which showed a bipolar structure in scattered light. The dominant near-IR feature is associated with the northern lobe of this scattering nebula, and the multi-wavelength dataset can be understood in terms of a bipolar dust shell around CIT 6. Variability of the near-IR morphology is qualitatively consistent with previously observed changes in red polarization, caused by varying illumination geometry due to non-uniform dust production. The blue emission morphology and polarization properties can not be explained by the above model alone, but require the presence of a wide binary companion in the vicinity of the southern polar lobe. The physical mechanisms responsible for the breaking of spherical symmetry around extreme carbon stars, such as CIT 6 and IRC+10216, remain uncertain.Comment: 18 pages, 5 figures (one in color), to appear in the Astrophysical Journa

Equipotential Surfaces and Lagrangian points in Non-synchronous, Eccentric Binary and Planetary Systems

We investigate the existence and properties of equipotential surfaces and Lagrangian points in non-synchronous, eccentric binary star and planetary systems under the assumption of quasi-static equilibrium. We adopt a binary potential that accounts for non-synchronous rotation and eccentric orbits, and calculate the positions of the Lagrangian points as functions of the mass ratio, the degree of asynchronism, the orbital eccentricity, and the position of the stars or planets in their relative orbit. We find that the geometry of the equipotential surfaces may facilitate non-conservative mass transfer in non-synchronous, eccentric binary star and planetary systems, especially if the component stars or planets are rotating super-synchronously at the periastron of their relative orbit. We also calculate the volume-equivalent radius of the Roche lobe as a function of the four parameters mentioned above. Contrary to common practice, we find that replacing the radius of a circular orbit in the fitting formula of Eggleton (1983) with the instantaneous distance between the components of eccentric binary or planetary systems does not always lead to a good approximation to the volume-equivalent radius of the Roche-lobe. We therefore provide generalized analytic fitting formulae for the volume-equivalent Roche lobe radius appropriate for non-synchronous, eccentric binary star and planetary systems. These formulae are accurate to better than 1% throughout the relevant 2-dimensional parameter space that covers a dynamic range of 16 and 6 orders of magnitude in the two dimensions.Comment: 12 pages, 10 figures, 2 Tables, Accepted by the Astrophysical Journa

The `666' collaboration on OGLE transits: I. Accurate radius of the planets OGLE-TR-10b and OGLE-TR-56b with VLT deconvolution photometry

Transiting planets are essential to study the structure and evolution of extra-solar planets. For that purpose, it is important to measure precisely the radius of these planets. Here we report new high-accuracy photometry of the transits of OGLE-TR-10 and OGLE-TR-56 with VLT/FORS1. One transit of each object was covered in Bessel V and R filters, and treated with the deconvolution-based photometry algorithm DECPHOT, to ensure accurate millimagnitude light curves. Together with earlier spectroscopic measurements, the data imply a radius of 1.22 +0.12-0.07 R_J for OGLE-TR-10b and 1.30 +- 0.05 R_J for OGLE-TR-56b. A re-analysis of the original OGLE photometry resolves an earlier discrepancy about the radius of OGLE-TR-10. The transit of OGLE-TR-56 is almost grazing, so that small systematics in the photometry can cause large changes in the derived radius. Our study confirms both planets as inflated hot Jupiters, with large radii comparable to that of HD 209458$b$ and at least two other recently discovered transiting gas giants.Comment: Fundamental updates compared to previous version; accepted for publication in Astronomy & Astrophysic

Quantitative Microbial Risk Assessment of Antibacterial Hand Hygiene Products on Risk of Shigellosis

ABSTRACT There are conflicting reports on whether antibacterial hand hygiene products are more effective than nonantibacterial products in reducing bacteria on hands and preventing disease. This research used new laboratory data, together with simulation techniques, to compare the ability of nonantibacterial and antibacterial products to reduce shigellosis risk. One hundred sixtythree subjects were used to compare five different hand treatments: two nonantibacterial products and three antibacterial products, i.e., 0.46% triclosan, 4% chlorhexidine gluconate, or 62% ethyl alcohol. Hands were inoculated with 5.5 to 6 log CFU Shigella; the simulated food handlers then washed their hands with one of the five products before handling melon balls

An eclipsing binary distance to the Large Magellanic Cloud accurate to 2 per cent

In the era of precision cosmology it is essential to determine the Hubble Constant with an accuracy of 3% or better. Currently, its uncertainty is dominated by the uncertainty in the distance to the Large Magellanic Cloud (LMC) which as the second nearest galaxy serves as the best anchor point of the cosmic distance scale. Observations of eclipsing binaries offer a unique opportunity to precisely and accurately measure stellar parameters and distances. The eclipsing binary method was previously applied to the LMC but the accuracy of the distance results was hampered by the need to model the bright, early-type systems used in these studies. Here, we present distance determinations to eight long-period, late- type eclipsing systems in the LMC composed of cool giant stars. For such systems we can accurately measure both the linear and angular sizes of their components and avoid the most important problems related to the hot early-type systems. Our LMC distance derived from these systems is demonstrably accurate to 2.2 % (49.97 +/- 0.19 (statistical) +/- 1.11 (systematic) kpc) providing a firm base for a 3 % determination of the Hubble Constant, with prospects for improvement to 2 % in the future.Comment: 34 pages, 5 figures, 13 tables, published in the Nature, a part of our data comes from new unpublished OGLE-IV photometric dat

A polygenic risk score for multiple myeloma risk prediction

There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low individual penetrance. Combining the SNPs in a polygenic risk score (PRS) is a possible approach to improve their usefulness. Using 2361 MM cases and 1415 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, we computed a weighted and an unweighted PRS. We observed associations with MM risk with OR = 3.44, 95% CI 2.53–4.69, p = 3.55 × 10−15 for the highest vs. lowest quintile of the weighted score, and OR = 3.18, 95% CI 2.1 = 34–4.33, p = 1.62 × 10−13 for the highest vs. lowest quintile of the unweighted score. We found a convincing association of a PRS generated with 23 SNPs and risk of MM. Our work provides additional validation of previously discovered MM risk variants and of their combination into a PRS, which is a first step towards the use of genetics for risk stratification in the general population