Социальное благополучие как критерий эффективности неоиндустриализации экономики

Неоиндустриализация предполагает экономику, основанную на знаниях и сетях. В отличие от индустриальной экономики, где ключевыми факторами развития являются добыча и переработка сырья, в новой экономике будет доминировать инженерное творчество, дизайн и программирование. Это коренным образом меняет картину социального благополучия, которое выступает, с одной стороны, критерием, с другой - конечным результатом неоиндустриализации экономики

Inter-sample contamination detection using mixture deconvolution comparison

© 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 12 month embargo from date of publication (February 2019) in accordance with the publisher’s archiving policyA recent publication has provided the ability to compare two mixed DNA profiles and consider their probability of occurrence if they do, compared to if they do not, have a common contributor. This ability has applications to both quality assurance (to test for sample to sample contamination) and for intelligence gathering purposes (did the same unknown offender donate DNA to multiple samples). We use a mixture to mixture comparison tool to investigate the prevalence of sample to sample contamination that could occur from two laboratory mechanisms, one during DNA extraction and one during electrophoresis. By carrying out pairwise comparisons of all samples (deconvoluted using probabilistic genotyping software STRmix™) within extraction or run batches we identify any potential common DNA donors and investigate these with respect to their risk of contamination from the two proposed mechanisms. While not identifying any contamination, we inadvertently find a potential intelligence link between samples, showing the use of a mixture to mixture comparison tool for investigative purposes

Internal validation of STRmix™ – A multi laboratory response to PCAST

We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number

Postmenopausal hormones and sleep quality in the elderly: a population based study

<p>Abstract</p> <p>Background</p> <p>Sleep disturbance and insomnia are commonly reported by postmenopausal women. However, the relationship between hormone therapy (HT) and sleep disturbances in postmenopausal community-dwelling adults is understudied. Using data from the multicenter Study of Osteoporotic Fractures (SOF), we tested the relationship between HT and sleep-wake estimated from actigraphy.</p> <p>Methods</p> <p>Sleep-wake was ascertained by wrist actigraphy in 3,123 women aged 84 ± 4 years (range 77-99) from the Study of Osteoporotic Fractures (SOF). This sample represents 30% of the original SOF study and 64% of participants seen at this visit. Data were collected for a mean of 4 consecutive 24-hour periods. Sleep parameters measured objectively included total sleep time, sleep efficiency (SE), sleep latency, wake after sleep onset (WASO), and nap time. All analyses were adjusted for potential confounders (age, clinic site, race, BMI, cognitive function, physical activity, depression, anxiety, education, marital status, age at menopause, alcohol use, prior hysterectomy, and medical conditions).</p> <p>Results</p> <p>Actigraphy measurements were available for 424 current, 1,289 past, and 1,410 never users of HT. Women currently using HT had a shorter WASO time (76 vs. 82 minutes, P = 0.03) and fewer long-wake (≥ 5 minutes) episodes (6.5 vs. 7.1, P = 0.004) than never users. Past HT users had longer total sleep time than never users (413 vs. 403 minutes, P = 0.002). Women who never used HT had elevated odds of SE <70% (OR,1.37;95%CI,0.98-1.92) and significantly higher odds of WASO ≥ 90 minutes (OR,1.37;95%CI,1.02-1.83) and ≥ 8 long-wake episodes (OR,1.58;95%CI,1.18-2.12) when compared to current HT users.</p> <p>Conclusions</p> <p>Postmenopausal women currently using HT had improved sleep quality for two out of five objective measures: shorter WASO and fewer long-wake episodes. The mechanism behind these associations is not clear. For postmenopausal women, starting HT use should be considered carefully in balance with other risks since the vascular side-effects of hormone replacement may exceed its beneficial effects on sleep.</p

Recommendations for Enhancing Psychosocial Support of NICU Parents through Staff Education and Support

Providing psychosocial support to parents whose infants are hospitalized in the neonatal intensive care unit (NICU) can improve parents’ functioning as well as their relationships with their babies. Yet, few NICUs offer staff education that teaches optimal methods of communication with parents in distress. Limited staff education in how to best provide psychosocial support to families is one factor that may render those who work in the NICU at risk for burnout, compassion fatigue and secondary traumatic stress syndrome. Staff who develop burnout may have further reduced ability to provide effective support to parents and babies. Recommendations for providing NICU staff with education and support are discussed. The goal is to deliver care that exemplifies the belief that providing psychosocial care and support to the family is equal in importance to providing medical care and developmental support to the baby

Is Homosexuality a Paraphilia? The Evidence For and Against

Whether homosexuality should be described as one among many paraphilic sexual interests or an altogether different dimension of sexual interest has long been discussed in terms of its political and social implications. The present article examined the question instead by comparing the major correlates and other features of homosexuality and of the paraphilias, including prevalence, sex ratio, onset and course, fraternal birth order, physical height, handedness, IQ and cognitive neuropsychological profile, and neuroanatomy. Although those literatures remain underdeveloped, the existing findings thus far suggest that homosexuality has a pattern of correlates largely, but not entirely, distinct from that identified among the paraphilias. At least, if homosexuality were deemed a paraphilia, it would be relatively unique among them, taxonometrically speaking

De schoen wringt, maar waar? Discrepanties tussen het trainen, evalueren en praktiseren van consultvoeringsvaardigheden

Recent gepubliceerd onderzoek naar consultvoeringsvaardigheden van huisartsen wekt de indruk dat het onderwijs weinig vruchten afwerpt. Het is de vraag of de gebruikte onderzoeksmethoden wel meten wat ze moeten meten. Nadere analyse van de literatuur op dit terrein laat onder meer zien dat de communicatie tussen arts en patiënt afhangt van de doelstellingen die op een bepaald moment in een consult worden nagestreefd. Daarnaast dragen ook kenmerken van de patiënt en de gepresenteerde problematiek er toe bij dat niet alle gesprekstechnieken in elk consult kunnen worden teruggezien. Een betrouwbaar beeld van de vaardigheden van een huisarts kan zodoende pas worden verkregen wanneer voor elke fase in een consult gespreksdoelen met daaraan gekoppelde consultvoeringsvaardigheden geformuleerd worden en wanneer bovendien per huisarts een groter aantal consulten bestudeerd wordt