Geothermal reservoir engineering research

The Stanford University research program on the study of stimulation and reservoir engineering of geothermal resources commenced as an interdisciplinary program in September, 1972. The broad objectives of this program have been: (1) the development of experimental and computational data to evaluate the optimum performance of fracture-stimulated geothermal reservoirs; (2) the development of a geothermal reservoir model to evaluate important thermophysical, hydrodynamic, and chemical parameters based on fluid-energy-volume balances as part of standard reservoir engineering practice; and (3) the construction of a laboratory model of an explosion-produced chimney to obtain experimental data on the processes of in-place boiling, moving flash fronts, and two-phase flow in porous and fractured hydrothermal reservoirs

Resource Use, Dependence and Vulnerability: Community-Resource Linkages on Alaska’s Tongass National Forest

Understanding how rural communities use and depend upon local natural resources is a critical factor in developing policies to sustain the long-term viability of human and natural systems. Such “community-resource” linkages are particularly important in Alaska, where rural communities – many of them comprised of indigenous Alaskan Natives – are highly dependent upon local resources found on public lands. Alaskan communities utilize forests in many ways. To better understand these coupled “social-ecological” systems, we combined socio-economic data from the 2000 U.S. Census with timber permit data from the USDA Forest Service to describe communities and their use of forest resources. Our results suggest that private access to public resources is an important feature of Alaskan communities, and that continued access is likely to be a key factor in sustaining human systems on the landscape. As a result, public land managers should give special consideration to local resource use when making policy decisions

Use of Agrotain to reduce the seedbed toxicity of urea

Non-Peer Reviewe

Genetic analysis of Eclosion hormone action during Drosophila larval ecdysis

Insect growth is punctuated by molts, during which the animal produces a new exoskeleton. The molt culminates with ecdysis, an ordered sequence of behaviors that causes the old cuticle to be shed. This sequence is activated by Ecdysis Triggering Hormone (ETH), which acts on the CNS to activate neurons that produce neuropeptides implicated in ecdysis, including Eclosion hormone (EH), Crustacean Cardioactive Peptide (CCAP), and bursicon. Despite over 40 years of research on ecdysis, our understanding of the precise roles of these neurohormones remains rudimentary. Of particular interest is EH, whose role beyond the well-accepted action of massively upregulating ETH release has remained elusive. We report on the isolation of an eh null mutant in Drosophila, and use it to investigate the role of EH in larval ecdysis. We found that null mutant animals invariably died at around the time of ecdysis, revealing an essential role in its control. Unexpectedly, however, they failed to express the preparatory behavior of pre-ecdysis while directly expressing the motor program of ecdysis. In addition, although ETH release could not be detected in these animals, the lack of pre-ecdysis could not be rescued by injections of ETH, suggesting that EH is required within the CNS for ETH to trigger the normal ecdysial sequence. Using a genetically-encoded calcium probe we show that EH configures the response of the CNS to ETH. These findings show that EH plays an essential role in the Drosophila CNS in the control of ecdysis, in addition to its known role in the periphery of triggering ETH release.</jats:p

The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the inner ear

After noise- or drug-induced hair-cell loss, the sensory epithelia of the avian inner ear can regenerate new hair cells. Few molecular markers are available for the supporting-cell precursors of the hair cells that regenerate, and little is known about the signaling mechanisms underlying this regenerative response. Hybridoma methodology was used to obtain a monoclonal antibody (mAb) that stains the apical surface of supporting cells in the sensory epithelia of the inner ear. The mAb recognizes the supporting-cell antigen (SCA), a protein that is also found on the apical surfaces of retinal Müller cells, renal tubule cells, and intestinal brush border cells. Expression screening and molecular cloning reveal that the SCA is a novel receptor-like protein tyrosine phosphatase (RPTP), sharing similarity with human density-enhanced phosphatase, an RPTP thought to have a role in the density-dependent arrest of cell growth. In response to hair-cell damage induced by noise in vivo or hair-cell loss caused by ototoxic drug treatment in vitro, some supporting cells show a dramatic decrease in SCA expression levels on their apical surface. This decrease occurs before supporting cells are known to first enter S-phase after trauma, indicating that it may be a primary rather than a secondary response to injury. These results indicate that the SCA is a signaling molecule that may influence the potential of nonsensory supporting cells to either proliferate or differentiate into hair cell

Behaviours preceding suicides at railway and underground locations: a multimethodological qualitative approach

Background: Suicides by train have devastating consequences for families, the rail industry, staff dealing with the aftermath of such incidents, and potential witnesses. To reduce suicides and suicide attempts by rail it is important to learn how safe interventions can be made. However, very little is known about how to identify someone who may be about to make a suicide attempt at a railway location (including underground/subways). The current research employed a novel way of understanding what behaviours might immediately precede a suicide or suicide attempt at these locations. Design and Methods: A qualitative thematic approach was used for three parallel studies. Data were gathered from several sources including: interviews with individuals who survived a suicide attempt at a railway or underground location (N=9); CCTV footage of individuals who died by suicide at a rail or underground location (N=16); and qualitative survey data providing views from rail staff (N=79). Results: Our research suggests there are several behaviours that people may carry out before a suicide or suicide attempt at a rail location including: station hopping and platform switching; limiting contact with others; positioning themselves at the end of the track where the train/tube approaches; allowing trains to pass by; and carrying out repetitive behaviours. Interpretation: There are several behaviours that may be identifiable in the moments leading up to a suicide or suicide attempt on the railways, which may present opportunities for intervention. These findings have implications for several stakeholders including rail providers, transport police and other organisations focused on suicide prevention

Quasi-2D Confinement of a BEC in a Combined Optical and Magnetic Potential

We have added an optical potential to a conventional Time-averaged Orbiting Potential (TOP) trap to create a highly anisotropic hybrid trap for ultracold atoms. Axial confinement is provided by the optical potential; the maximum frequency currently obtainable in this direction is 2.2 kHz for rubidium. The radial confinement is independently controlled by the magnetic trap and can be a factor of 700 times smaller than in the axial direction. This large anisotropy is more than sufficient to confine condensates with ~10^5 atoms in a Quasi-2D (Q2D) regime, and we have verified this by measuring a change in the free expansion of the condensate; our results agree with a variational model.Comment: 11 pages, 10 figur

Many-body nodal hypersurface and domain averages for correlated wave functions

We outline the basic notions of nodal hypersurface and domain averages for antisymmetric wave functions. We illustrate their properties and analyze the results for a few electron explicitly solvable cases and discuss possible further developments