Kinetics of the reaction of nitric oxide with hydrogen

Mixtures of NO and H2 diluted in argon or krypton were heated by incident shock waves, and the infrared emission from the fundamental vibration-rotation band of NO at 5.3 microns was used to monitor the time-varying NO concentration. The reaction kinetics were studied in the temperature range 2400-4500 K using a shock-tube technique. The decomposition of nitric oxide behind the shock was found to be modeled well by a fifteen-reaction system. A principle result of the study was the determination of the rate constant for the reaction H + NO yields N + OH, which may be the rate-limiting step for NO removal in some combustion systems. Experimental values of k sub 1 were obtained for each test through comparisons of measured and numerically predicted NO profiles

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease.

Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that leads to renal failure in the majority of patients. The very first pharmacological treatment, tolvaptan, received Food and Drug Administration approval in 2018 after previous approval in Europe and other countries. However, tolvaptan is moderately effective and may negatively impact a patient's quality of life due to potentially significant side effects. Additional and improved therapies are still urgently needed, and several clinical trials are underway, which are discussed in the companion paper Müller and Benzing (Management of autosomal-dominant polycystic kidney disease-state-of-the-art) Clin Kidney J 2018; 11: i2-i13. Here, we discuss new therapeutic avenues that are currently being investigated at the preclinical stage. We focus on mammalian target of rapamycin and dual kinase inhibitors, compounds that target inflammation and histone deacetylases, RNA-targeted therapeutic strategies, glucosylceramide synthase inhibitors, compounds that affect the metabolism of renal cysts and dietary restriction. We discuss tissue targeting to renal cysts of small molecules via the folate receptor, and of monoclonal antibodies via the polymeric immunoglobulin receptor. A general problem with potential pharmacological approaches is that the many molecular targets that have been implicated in ADPKD are all widely expressed and carry out important functions in many organs and tissues. Because ADPKD is a slowly progressing, chronic disease, it is likely that any therapy will have to continue over years and decades. Therefore, systemically distributed drugs are likely to lead to potentially prohibitive extra-renal side effects during extended treatment. Tissue targeting to renal cysts of such drugs is one potential way around this problem. The use of dietary, instead of pharmacological, interventions is another

Decomposition of NO studied by infrared emission and CO laser absorption

A diagnostic technique for monitoring the concentration of NO using absorption of CO laser radiation was developed and applied in a study of the decomposition kinetics of NO. Simultaneous measurements of infrared emission by NO at 5.3 microns were also made to validate the laser absorption technique. The data were obtained behind incident shocks in NO-N2O-Ar (or Kr) mixtures, with temperatures in the range 2400-4100 K. Rate constants for dominant reactions were inferred from comparisons with computer simulations of the reactive flow

A detector for continuous measurement of ultra-cold atoms in real time

We present the first detector capable of recording high-bandwidth real time atom number density measurements of a Bose Einstein condensate. Based on a two-color Mach-Zehnder interferometer, our detector has a response time that is six orders of magnitude faster than current detectors based on CCD cameras while still operating at the shot-noise limit. With this minimally destructive system it may be possible to implement feedback to stabilize a Bose-Einstein condensate or an atom laser.Comment: 3 pages, 3 figures, submitted to optics letter

Midlife women, bone health, vegetables, herbs and fruit study. The Scarborough Fair study protocol

BACKGROUND: Bone loss is accelerated in middle aged women but increased fruit/vegetable intake positively affects bone health by provision of micronutrients essential for bone formation, buffer precursors which reduce acid load and phytochemicals affecting inflammation and oxidative stress. Animal studies demonstrated bone resorption inhibiting properties of specific vegetables, fruit and herbs a decade ago. Objective: To increase fruit/vegetable intake in post menopausal women to 9 servings/day using a food specific approach to significantly reduce dietary acid load and include specific vegetables, fruit and herbs with bone resorbing inhibiting properties to assess effect on bone turnover, metabolic and inflammatory markers. METHODS/DESIGN: The Scarborough Fair Study is a randomised active comparator controlled multi centre trial. It aimed to increase fruit and vegetable intake in 100 post menopausal women from ≤ 5 servings/day to ≥ 9 servings/day for 3 months. The women in the dietary intervention were randomly assigned to one of the two arms of the study. Both groups consumed ≥ 9 servings/day of fruit/vegetables and selected herbs but the diet of each group emphasised different fruit/vegetables/herbs with one group (B) selecting from a range of vegetables, fruit and culinary herbs with bone resorbing inhibiting properties. 50 women formed a negative control group (Group C usual diet). Primary outcome variables were plasma bone markers assessed at baseline, 6 weeks and 12 weeks. Secondary outcome variables were plasma inflammation and metabolic markers and urinary electrolytes (calcium, magnesium, potassium and sodium) assessed at baseline and 12 weeks. Dietary intake and urine pH change also were outcome variables. The dietary change was calculated with 3 day diet diaries and a 24 hour recall. Intervention participants kept a twice weekly record of fruit, vegetable and herb intake and urine pH. DISCUSSION: This study will provide information on midlife women’s bone health and how a dietary intervention increasing fruit and vegetable/herb intake affects bone, inflammatory and metabolic markers and urinary electrolyte excretion. It assesses changes in nutrient intake, estimated dietary acid load and sodium: potassium ratios. The study also explores whether specific fruit/vegetables and herbs with bone resorbing properties has an effect on bone markers. TRIAL REGISTRATION: ACTRN 1261100076394

Nutritional environment at secondary schools in Bloemfontein, South Africa

Objective: The objective was to determine the nutritional environment at secondary schools in Bloemfontein, Free State province.Design: This was a cross-sectional, descriptive study.Subjects and setting: The subjects were secondary school principals in Bloemfontein, Free State province, in 2006.Method: Principals of 10 secondary schools who were already participating in a larger study on 26 schools completed structured questionnaireson nutrition practices.Results: Four schools utilised nutrition education programmes. None had vending machines. Two schools sold dairy products. Biscuits andchocolates were sold at eight schools, and sweets, crisps and fast food at all of the schools.Conclusion: The nutrition environment at Bloemfontein secondary schools does not support healthy eating habits. Nutrition policies need tobe introduced to improve the nutritional environment at schools as the available food for learners at the tuck shops and/or via the vendorswas mostly unhealthy

Many-body nodal hypersurface and domain averages for correlated wave functions

We outline the basic notions of nodal hypersurface and domain averages for antisymmetric wave functions. We illustrate their properties and analyze the results for a few electron explicitly solvable cases and discuss possible further developments

Naturally Rehearsing Passwords

We introduce quantitative usability and security models to guide the design of password management schemes --- systematic strategies to help users create and remember multiple passwords. In the same way that security proofs in cryptography are based on complexity-theoretic assumptions (e.g., hardness of factoring and discrete logarithm), we quantify usability by introducing usability assumptions. In particular, password management relies on assumptions about human memory, e.g., that a user who follows a particular rehearsal schedule will successfully maintain the corresponding memory. These assumptions are informed by research in cognitive science and validated through empirical studies. Given rehearsal requirements and a user's visitation schedule for each account, we use the total number of extra rehearsals that the user would have to do to remember all of his passwords as a measure of the usability of the password scheme. Our usability model leads us to a key observation: password reuse benefits users not only by reducing the number of passwords that the user has to memorize, but more importantly by increasing the natural rehearsal rate for each password. We also present a security model which accounts for the complexity of password management with multiple accounts and associated threats, including online, offline, and plaintext password leak attacks. Observing that current password management schemes are either insecure or unusable, we present Shared Cues--- a new scheme in which the underlying secret is strategically shared across accounts to ensure that most rehearsal requirements are satisfied naturally while simultaneously providing strong security. The construction uses the Chinese Remainder Theorem to achieve these competing goals

Quasi-2D Confinement of a BEC in a Combined Optical and Magnetic Potential

We have added an optical potential to a conventional Time-averaged Orbiting Potential (TOP) trap to create a highly anisotropic hybrid trap for ultracold atoms. Axial confinement is provided by the optical potential; the maximum frequency currently obtainable in this direction is 2.2 kHz for rubidium. The radial confinement is independently controlled by the magnetic trap and can be a factor of 700 times smaller than in the axial direction. This large anisotropy is more than sufficient to confine condensates with ~10^5 atoms in a Quasi-2D (Q2D) regime, and we have verified this by measuring a change in the free expansion of the condensate; our results agree with a variational model.Comment: 11 pages, 10 figur

CP violation in the decay mode B→πγγB\to \pi \gamma \gamma

Within the framework of Standard Model, the exclusive decay mode $B\to \pi \gamma \gamma$ is studied. Although the usual short distance contribution is small compared to the similar $B\to K\gamma\gamma$ mode, the process offers the possibility of studying the CP violation, a feature absent in the $B \to K$ counterpart.Comment: 11 page latex file including 2 ps figures. Typos corrected, minor changes. To appear in PR