On Zone-Based Analysis of Duration Probabilistic Automata

We propose an extension of the zone-based algorithmics for analyzing timed automata to handle systems where timing uncertainty is considered as probabilistic rather than set-theoretic. We study duration probabilistic automata (DPA), expressing multiple parallel processes admitting memoryfull continuously-distributed durations. For this model we develop an extension of the zone-based forward reachability algorithm whose successor operator is a density transformer, thus providing a solution to verification and performance evaluation problems concerning acyclic DPA (or the bounded-horizon behavior of cyclic DPA).Comment: In Proceedings INFINITY 2010, arXiv:1010.611

Worldsheet Dynamics of String Junctions

We analyze scattering of string modes at string junctions of type IIB string theory. In the infrared limit, certain orthogonal linear combinations of the fields on the different strings satisfy either Dirichlet or Neumann boundary conditions. We confirm that the worldsheet theory of a general string network has eight conserved supercharges in agreement with target space BPS considerations. As an application, we obtain the band spectrum of some simple string lattices.Comment: latex, 19 pages with two figure

Regional Planning and Local Autonomy in Washington Zoning Law

The rapid urbanization of large areas of Washington call for effective land use planning and zoning. At present, regional and state land use plans are implemented, if at all, only by the grace of local zoning officials. This comment discusses the means available for adjusting the relationships between local zoning officials and extra-municipal planners so as to preserve local autonomy without destroying the effectiveness of state and regional plans. The authors conclude that the adoption of portions of the Model Land Development Code would accomplish this result

Under the radar: Industry entry by user entrepreneurs

We inductively develop a model of the commercialization process for new products or services user entrepreneurs undertake when entering an industry while drawing on proprietary technology developed in another industry. Extending the growing field of user entrepreneurship, we identify a two-phase approach to industry entry by user entrepreneurs who start "under the radar" of incumbent firms, gain experience, attract a first potential customer base, and then, in a second phase, engage in commercialization. During this process, a community of fellow users is of major importance for the entrepreneur, serving as a knowledge pool for skills development and experimentation with different commercialization paths. We study a nascent group of firms founded by users of video games who became entrepreneurs on entering the animation industry by producing Machinima, a new film genre characterized by shooting film in video games. We explain how user entrepreneurs gain access to complementary assets (video games) for their new use (shooting film), how they deal with intellectual property issues when using other firms' assets, and how user entrepreneurs combine domain knowledge about film production with their experience in video games and the art of Machinima. Our propositions hold implications for management and policy

Communal resources in open source software development

Introduction: Virtual communities play an important role in innovation. The paper focuses on the particular form of collective action in virtual communities underlying as Open Source software development projects. Method: Building on resource mobilization theory and private-collective innovation, we propose a theory of collective action in innovative virtual communities. We identify three communal resources (reputation, control over technology and learning opportunities) that appear as a byproduct while developing open source software. Analysis:Constructs are derived from exiting literature. Empirical data from Freenet, an open source software project for peer-to-peer software, illustrates both the levels of involvement and the communal resources. Results & conclusions: Communal resources are able to solve the collective action dilemma for virtual communities. We show that they increase in value for individuals along with their involvement in the community

What makes a social practice? Being, knowing, doing and leading

Despite several decades of work on social practice, many open intriguing questions remain about their existence and functions within an organizational context. In this article, we discuss the “inherent logics” of social practice—being, knowing, and doing—to depict the meaning and mainspring of its conservation within an organizational context. We argue that the understanding of social practice in organization and management studies has predominantly focused on the internal workings of social practice, and we propose that a contextualization of the inherent logics of social practice may be a next step in advancing theory and empirical research. We propose a contested coexistence of social practices in organizations and thereby argue that the conservation of social practice protrudes another element belonging to its inherent logics, i.e., leading. We suggest that leadership in distributed and adaptive organizations responds to innovation and competitive challenges with wisdom, care, and fluidity

Carrots and Rainbows: Motivation and Social Practice in Open Source Software Development

Open source software (OSS) is a social and economic phenomenon that raises fundamental questions about the motivations of contributors to information systems development. Some developers are unpaid volunteers who seek to solve their own technical problems, while others create OSS as part of their employment contract. For the past 10 years, a substantial amount of academic work has theorized about and empirically examined developer motivations. We review this work and suggest considering motivation in terms of the values of the social practice in which developers participate. Based on the social philosophy of Alasdair MacIntyre, we construct a theoretical framework that expands our assumptions about individual motivation to include the idea of a long-term, value-informed quest beyond short-term rewards. This motivation-practice framework depicts how the social practice and its supporting institutions mediate between individual motivation and outcome. The framework contains three theoretical conjectures that seek to explain how collectively elaborated standards of excellence prompt developers to produce high-quality software, change institutions, and sustain OSS development. From the framework, we derive six concrete propositions and suggest a new research agenda on motivation in OSS

Medical ovariectomy in menopausal breast cancer patients with high testosterone levels : a further step toward tailored therapy

Five years of adjuvant therapy with anti-estrogens reduce the incidence of disease progression by about 50% in estrogen receptor-positive breast cancer patients, but late relapse can still occur after anti-estrogens have been discontinued. In these patients, excessive androgen production may account for renewed excessive estrogen formation and increased risks of late relapse. In the 50% of patients who do not benefit with anti-estrogens, the effect of therapy is limited by de novo or acquired resistance to treatment. Androgen receptor and epidermal growth factor receptor overexpression are recognized mechanisms of endocrine resistance suggesting the involvement of androgens as activators of the androgen receptor pathway and as stimulators of epidermal growth factor synthesis and function. Data from a series of prospective studies on operable breast cancer patients, showing high serum testosterone levels are associated to increased risk of recurrence, provide further support to a role for androgens in breast cancer progression. According to the above reported evidence, we proposed to counteract excessive androgen production in the adjuvant setting of estrogen receptor-positive patients and suggested selecting postmenopausal patients with elevated levels of serum testosterone, marker of ovarian hyperandrogenemia, for adjuvant treatment with a gonadotropins-releasing hormone analogue (medical oophorectomy) in addition to standard therapy with anti-estrogens. The proposed approach provides an attempt of personalized medicine that needs to be further investigated in clinical trials

Usual energy and macronutrient intakes in 2-9-year-old European children

OBJECTIVE: Valid estimates of population intakes are essential for monitoring trends as well as for nutritional interventions, but such data are rare in young children. In particular, the problem of misreporting in dietary data is usually not accounted for. Therefore, this study aims to provide accurate estimates of intake distributions in European children. DESIGN: Cross-sectional setting-based multi-centre study. SUBJECTS: A total of 9560 children aged 2-9 years from eight European countries with at least one 24-h dietary recall (24-HDR). METHODS: The 24-HDRs were classified in three reporting groups based on age- and sex-specific Goldberg cutoffs (underreports, plausible reports, overreports). Only plausible reports were considered in the final analysis (N=8611 children). The National Cancer Institute (NCI)-Method was applied to estimate population distributions of usual intakes correcting for the variance inflation in short-term dietary data. RESULTS: The prevalence of underreporting (9.5%) was higher compared with overreporting (3.4%). Exclusion of misreports resulted in a shift of the energy and absolute macronutrient intake distributions to the right, and further led to the exclusion of extreme values, that is, mean values and lower percentiles increased, whereas upper percentiles decreased. The distributions of relative macronutrient intakes (% energy intake from fat/carbohydrates/proteins) remained almost unchanged when excluding misreports. Application of the NCI-Method resulted in markedly narrower intake distributions compared with estimates based on single 24-HDRs. Mean percentages of usual energy intake from fat, carbohydrates and proteins were 32.2, 52.1 and 15.7%, respectively, suggesting the majority of European children are complying with common macronutrient intake recommendations. In contrast, total water intake (mean: 1216.7 ml per day) lay below the recommended value for >90% of the children. CONCLUSION: This study provides recent estimates of intake distributions of European children correcting for misreporting as well as for the daily variation in dietary data. These data may help to assess the adequacy of young children's diets in Europe