21 research outputs found

    VAST Challenge 2016: Streaming Visual Analytics

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    The 2016 VAST Challenge returns to the (fictional) island of Kronos to pose three Mini-Challenges. In Mini-Challenge 1, participants must design an innovative interactive visual interface that enables security investigators from the Euybia Island Resort and Conference Center to conduct real-time analysis of streaming data. In Mini-Challenge 2, the GAStech Corporation returns from the 2014 kidnapping disaster more committed than ever to tighten up operations at its new headquarters in Abila. Using data from stationary and mobile sensors of multiple types, participants must help the company to understand both operational issues as well as security issues. In Mini-Challenge 3, participants are asked to try their hand at the most complex VAST Challenge scenario to date: 2.5 days of live, streaming operational data. The VAST Challenge 2016 received 29 submissions and had participation from 72 reviewers

    Exhaled Aerosol Transmission of Pandemic and Seasonal H1N1 Influenza Viruses in the Ferret

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    Person-to-person transmission of influenza viruses occurs by contact (direct and fomites) and non-contact (droplet and small particle aerosol) routes, but the quantitative dynamics and relative contributions of these routes are incompletely understood. The transmissibility of influenza strains estimated from secondary attack rates in closed human populations is confounded by large variations in population susceptibilities. An experimental method to phenotype strains for transmissibility in an animal model could provide relative efficiencies of transmission. We developed an experimental method to detect exhaled viral aerosol transmission between unanesthetized infected and susceptible ferrets, measured aerosol particle size and number, and quantified the viral genomic RNA in the exhaled aerosol. During brief 3-hour exposures to exhaled viral aerosols in airflow-controlled chambers, three strains of pandemic 2009 H1N1 strains were frequently transmitted to susceptible ferrets. In contrast one seasonal H1N1 strain was not transmitted in spite of higher levels of viral RNA in the exhaled aerosol. Among three pandemic strains, the two strains causing weight loss and illness in the intranasally infected ‘donor’ ferrets were transmitted less efficiently from the donor than the strain causing no detectable illness, suggesting that the mucosal inflammatory response may attenuate viable exhaled virus. Although exhaled viral RNA remained constant, transmission efficiency diminished from day 1 to day 5 after donor infection. Thus, aerosol transmission between ferrets may be dependent on at least four characteristics of virus-host relationships including the level of exhaled virus, infectious particle size, mucosal inflammation, and viral replication efficiency in susceptible mucosa
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