6 research outputs found
WebAnno-MM: EXMARaLDA meets WebAnno
No full textIn this paper, we present WebAnno-MM, an extension of the popular web-based annotation tool WebAnno, which is designed for the linguistic annotation of transcribed spoken data with time aligned media files. Several new features have been implemented for our current use case: a novel teaching method based on pair-wise manual annotation of transcribed video data and systematic comparison of agreement between students. To enable the annotation of transcribed spoken language data, apart from technical and data model related challenges, WebAnno-MM offers an additional view to data: a (musical) score view for the inspection of parallel utterances, which is relevant for various methodological research questions regarding the analysis of interactions of spoken content
T Cell Recognition of an Engineered MHC Class I Molecule: Implications for Peptide-Independent Alloreactivity
No full textPremature TCRαβ Expression and Signaling in Early Thymocytes Impair Thymocyte Expansion and Partially Block Their Development
No full textNeuronal profilins in health and disease: Relevance for spine plasticity and Fragile X syndrome
No full textTotal Synthesis of a Functional Designer Eukaryotic Chromosome
No full textDesigner Chromosome
One of the ultimate aims of synthetic biology is to build designer organisms from the ground up. Rapid advances in DNA synthesis has allowed the assembly of complete bacterial genomes. Eukaryotic organisms, with their generally much larger and more complex genomes, present an additional challenge to synthetic biologists.
Annaluru
et al.
(p.
55
, published online 27 March) designed a synthetic eukaryotic chromosome based on yeast chromosome III. The designer chromosome, shorn of destabilizing transfer RNA genes and transposons, is ∼14% smaller than its wild-type template and is fully functional with every gene tagged for easy removal.
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