Holography in 4D (Super) Higher Spin Theories and a Test via Cubic Scalar Couplings

The correspondences proposed previously between higher spin gauge theories and free singleton field theories were recently extended into a more complete picture by Klebanov and Polyakov in the case of the minimal bosonic theory in D=4 to include the strongly coupled fixed point of the 3d O(N) vector model. Here we propose an N=1 supersymmetric version of this picture. We also elaborate on the role of parity in constraining the bulk interactions, and in distinguishing two minimal bosonic models obtained as two different consistent truncations of the minimal N=1 model that retain the scalar or the pseudo-scalar field. We refer to these models as the Type A and Type B models, respectively, and conjecture that the latter is holographically dual to the 3d Gross-Neveu model. In the case of the Type A model, we show the vanishing of the three-scalar amplitude with regular boundary conditions. This agrees with the O(N) vector model computation of Petkou, thereby providing a non-trivial test of the Klebanov-Polyakov conjecture.Comment: 30p

Scalar Field Corrections to AdS_4 Gravity from Higher Spin Gauge Theory

We compute the complete contribution to the stress-energy tensor in the minimal bosonic higher spin theory in D=4 that is quadratic in the scalar field. We find arbitrarily high derivative terms, and that the total sign of the stress-energy tensor depends on the parity of the scalar field.Comment: 15 pages + appendix (30 pages

ECOdrug: A database connecting drugs and conservation of their targets across species

This is the author accepted manuscriptPharmaceuticals are designed to interact with specific molecular targets in humans and these targets generally have orthologs in other species. This provides opportunities for the drug discovery community to use alternative model species for drug development. It also means, however, there is potential for mode of action related effects in non-target wildlife species as many pharmaceuticals reach the environment through patient use and manufacturing wastes. Acquiring insight in drug target ortholog predictions across species and taxonomic groups has proven difficult because of the lack of an optimal strategy and because necessary information is spread across multiple and diverse sources and platforms. We introduce a new research platform tool, ECOdrug, that reliably connects drugs to their protein targets across divergent species. It harmonizes ortholog predictions from multiple sources via a simple user interface underpinning critical applications for a wide range of studies in pharmacology, ecotoxicology and comparative evolutionary biology. ECOdrug can be used to identify species with drug targets and identify drugs that interact with those targets. As such, it can be applied to support intelligent targeted drug safety testing by ensuring appropriate and relevant species are selected in ecological risk assessments. ECOdrug is freely accessible and available at: Http://www.ecodrug.org.Innovative Medicines Initiative Joint Undertaking under Intelligent Assessment of PharmaceuticalsEuropean Union’s Seventh Framework ProgrammeAstraZenecaNC3Rs funded projec

Photon capture cones and embedding diagrams of the Ernst spacetime

The differences between the character of the Schwarzschild and Ernst spacetimes are illustrated by comparing the photon capture cones, and the embedding diagrams of the $t=\mathrm{const}$ sections of the equatorial planes of both the ordinary and optical reference geometry of these spacetimes. The non-flat asymptotic character of the Ernst spacetime reflects itself in two manifest facts: the escape photon cones correspond to purely outward radial direction, and the embedding diagrams of both the ordinary and optical geometry shrink to zero radius asymptotically. Using the properties of the embedding diagrams, regions of these spacetimes which could have similar character are estimated, and it is argued that they can exist for the Ernst spacetimes with a sufficiently low strength of the magnetic field.Comment: 12 pages, 7 figure

An Exact Solution of 4D Higher-Spin Gauge Theory

We give a one-parameter family of exact solutions to four-dimensional higher-spin gauge theory invariant under a deformed higher-spin extension of SO(3,1) and parameterized by a zero-form invariant. All higher-spin gauge fields vanish, while the metric interpolates between two asymptotically AdS4 regions via a dS3-foliated domainwall and two H3-foliated Robertson-Walker spacetimes -- one in the future and one in the past -- with the scalar field playing the role of foliation parameter. All Weyl tensors vanish, including that of spin two. We furthermore discuss methods for constructing solutions, including deformation of solutions to pure AdS gravity, the gauge-function approach, the perturbative treatment of (pseudo-)singular initial data describing isometric or otherwise projected solutions, and zero-form invariants.Comment: 47 pages. v3: global properties of the solution clarified, minor corrections made, discussion and refs revise

Draft genome sequence of extended-spectrum-β-lactamase-producing Escherichia coli strain CCUG 62462, isolated from a urine sample

The draft genome sequence has been determined for an extended-spectrum-β-lactamase (ESBL)-producing (blaCTX-M-15) Escherichia coli strain (CCUG 62462), composed of 119 contigs and a total size of 5.27 Mb. This E. coli is serotype O25b and sequence type 131, a pandemic clonal group, causing worldwide antimicrobial-resistant infections

Pregnancy related back pain, is it related to aerobic fitness? A longitudinal cohort study

<p>Abstract</p> <p>Background</p> <p>Low back pain with onset during pregnancy is common and approximately one out of three women have disabling pain. The pathogenesis of the pain condition is uncertain and there is no information on the role of physical fitness. Whether poorer physical conditioning is a cause or effect of back pain is also disputed and information from prospective studies needed.</p> <p>Methods</p> <p>A cohort of pregnant women, recruited from maternal health care centers in central Sweden, were examined regarding estimated peak oxygen uptake by cycle ergometer test in early pregnancy, reported physical activity prior to pregnancy, basic characteristics, back pain during pregnancy and back pain postpartum.</p> <p>Results</p> <p>Back pain during the current pregnancy was reported by nearly 80% of the women. At the postpartum appointment this prevalence was 40%. No association was displayed between estimated peak oxygen uptake and incidence of back pain during and after pregnancy, adjusted for physical activity, back pain before present pregnancy, previous deliveries, age and weight. A significant inverse association was found between estimated peak oxygen uptake and back pain intensity during pregnancy and a direct association post partum, in a fully adjusted multiple linear regression analysis.</p> <p>Conclusions</p> <p>Estimated peak oxygen uptake and reported physical activity in early pregnancy displayed no influence on the onset of subsequent back pain during or after pregnancy, where the time sequence support the hypothesis that poorer physical deconditioning is not a cause but a consequence of the back pain condition. The mechanism for the attenuating effect of increased oxygen uptake on back pain intensity is uncertain.</p